Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Kwang-Hoon Chun"'
Autor:
Kwang-Hoon Chun, Hye Kyung Jin, Jeong-Hyun Yoon, Myeong Gyu Kim, Kyung Hee Choi, Eunyoung Kim, Hyunah Kim, Jin-Ki Kim, Gyudong Kim, Kyungim Kim, Ju-Yeun Lee, Eun Kyoung Chung, Young Sook Lee, Sandy Jeong Rhie
Publikováno v:
BMC Medical Education, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background An effective test mechanism to evaluate clinical knowledge and skills of the entry-level healthcare professionals is important for providing clinical competency and improving patient care. This study aimed to develop novel, innova
Externí odkaz:
https://doaj.org/article/fdde6a36700243938ad4309bc99b7d60
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 114-124 (2019)
Rho-associated kinases (ROCKs) have been reported to antagonize adipocyte differentiation, and inhibition of ROCKs by small molecules promotes adipogenesis. Surprisingly, our recent study revealed that the ROCK2-specific inhibitor KD025 (SLx-2119), s
Externí odkaz:
https://doaj.org/article/39e39f5cb9c3476aa29a1826041717a1
Autor:
Kwang-Hoon Chun
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1380 (2022)
Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality. MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein expression by suppressing translation, inducing mRNA cleavage, and promoting mR
Externí odkaz:
https://doaj.org/article/02cd63a2493a40fcb7eaa9ee01c209e5
Autor:
Duy Trong Vien Diep, Kyungki Hong, Triyeng Khun, Mei Zheng, Asad ul-Haq, Hee-Sook Jun, Young-Bum Kim, Kwang-Hoon Chun
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Adipose tissue is a specialized organ that synthesizes and stores fat. During adipogenesis, Rho and Rho-associated kinase (ROCK) 2 are inactivated, which enhances the expression of pro-adipogenic genes and induces the loss of actin stress fi
Externí odkaz:
https://doaj.org/article/bc681f112e094eaa874a9aaf9fccaa17
Autor:
Nhu Nguyen Quynh Tran, Kwang-Hoon Chun
Publikováno v:
Molecules, Vol 26, Iss 16, p 4747 (2021)
KD025, a ROCK2 isoform-specific inhibitor, has an anti-adipogenic activity which is not mediated by ROCK2 inhibition. To identify the target, we searched binding targets of KD025 by using the KINOMEscanTM screening platform, and we identified casein
Externí odkaz:
https://doaj.org/article/3ca41d4db52349b181cb1ee0d0111c41
Publikováno v:
Molecules, Vol 25, Iss 6, p 1369 (2020)
KD025 (SLx-2119), the first specific Rho-associated protein kinase 2 (ROCK2) inhibitor, is a potential new drug candidate currently undergoing several phase 2 clinical trials for psoriasis, idiopathic pulmonary fibrosis, chronic graft-versus-host dis
Externí odkaz:
https://doaj.org/article/27fcb2ec0e874b25b4d8961c8cf3a315
Autor:
Souska Zandi, Shintaro Nakao, Kwang-Hoon Chun, Paolo Fiorina, Dawei Sun, Ryoichi Arita, Ming Zhao, Enoch Kim, Olivier Schueller, Stewart Campbell, Mahdi Taher, Mark Ivan Melhorn, Alexander Schering, Francesca Gatti, Sara Tezza, Fang Xie, Andrea Vergani, Shigeo Yoshida, Keijiro Ishikawa, Muneo Yamaguchi, Fumiyuki Sasaki, Ruth Schmidt-Ullrich, Yasuaki Hata, Hiroshi Enaida, Mitsuko Yuzawa, Takehiko Yokomizo, Young-Bum Kim, Paul Sweetnam, Tatsuro Ishibashi, Ali Hafezi-Moghadam
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1173-1186 (2015)
Age is a major risk factor in age-related macular degeneration (AMD), but the underlying cause is unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 characteristics in eyes of aged mice, revealing immune changes in aging. ROCK i
Externí odkaz:
https://doaj.org/article/fe2a70bf023f435d8820d05229083c8e
Publikováno v:
Journal of Ginseng Research, Vol 39, Iss 1, Pp 46-53 (2015)
Background: Glucocorticoids (GCs) are commonly used in many chemotherapeutic protocols and play an important role in the normal regulation of bone remodeling. However, the prolonged use of GCs results in osteoporosis, which is partially due to apopto
Externí odkaz:
https://doaj.org/article/7552ee1201ee4b0eb45b9fc9dd6b209b
Autor:
Han-Joo Maeng, Jin-Ha Yoon, Kwang-Hoon Chun, Sung Tae Kim, Dong-Jin Jang, Ji-Eun Park, Yang Hee Kim, Seong-Bo Kim, Yu Chul Kim
Publikováno v:
Foods, Vol 8, Iss 10, p 448 (2019)
D-allulose, a C-3 epimer of D-fructose, is a rare monosaccharide used as a food ingredient or a sweetener. In the present study, the in vitro metabolic stability of D-allulose was examined in biorelevant media, that is, simulated gastric fluid (SGF)
Externí odkaz:
https://doaj.org/article/f5a5a5e0e66942d1a9b80b896bfb04c3
Publikováno v:
Pharmaceutics, Vol 11, Iss 3, p 108 (2019)
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion. Despi
Externí odkaz:
https://doaj.org/article/ea8dccf6141a42638c838d144243b3b5