Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kwang Woo Ko"'
Publikováno v:
eLife, Vol 10 (2021)
SARM1 is an inducible NAD+ hydrolase that triggers axon loss and neuronal cell death in the injured and diseased nervous system. While SARM1 activation and enzyme function are well defined, the cellular events downstream of SARM1 activity but prior t
Externí odkaz:
https://doaj.org/article/4877f3da02fe49ecbeaf4ea689071126
Autor:
Tong Wu, Jian Zhu, Amy Strickland, Kwang Woo Ko, Yo Sasaki, Caitlin B. Dingwall, Yurie Yamada, Matthew D. Figley, Xianrong Mao, Alicia Neiner, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109872- (2021)
Summary: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds, the TIR domai
Externí odkaz:
https://doaj.org/article/de9f3f8581274b08b0ab0cc8ca1a999f
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181257 (2017)
V-set and transmembrane domain-containing protein 5 (Vstm5), a newly characterized small membrane glycoprotein, can induce membrane protrusions in various cells. Vstm5 can modulate both the position and complexity of central neurons by altering their
Externí odkaz:
https://doaj.org/article/6220a4a334e042be82a9cbedb6a69463
Autor:
Yurie Yamada, Tong Wu, Jeffrey Milbrandt, Amy Strickland, Kwang Woo Ko, Matthew D. Figley, Alicia Neiner, Jian Zhu, Aaron DiAntonio, Xianrong Mao, Caitlin B. Dingwall, Yo Sasaki, A. Joseph Bloom
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109872-(2021)
Cell Rep
Cell Rep
SUMMARYSARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds, the TIR domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867fed9ee01fe23f6560a3abd2fefa32
http://www.sciencedirect.com/science/article/pii/S2211124721013395
http://www.sciencedirect.com/science/article/pii/S2211124721013395
Autor:
Daina Avizonis, Jian Zhu, Jeffrey Milbrandt, Yihang Li, Maria F. Pazyra-Murphy, sophia tang, Johann Bergholz, Mariana De Sa Tavares Russo, Kwang Woo Ko, Aaron DiAntonio, Tao Jiang, Rosalind A. Segal, Jean J. Zhao
Publikováno v:
SSRN Electronic Journal.
Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a8e6e1e9e02613d7897771be1692620
https://doi.org/10.2139/ssrn.3830010
https://doi.org/10.2139/ssrn.3830010
Publikováno v:
Journal of Cell Biology. 219
Neuroinflammation and necroptosis are major contributors to neurodegenerative disease, and axon dysfunction and degeneration is often an initiating event. SARM1 is the central executioner of pathological axon degeneration. Here, we demonstrate functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c29517442d9c9216e5c7f8022c1f84
https://doi.org/10.1083/jcb.201912047
https://doi.org/10.1083/jcb.201912047
Publikováno v:
Mobile Information Systems, Vol 2018 (2018)
Stereo vision is used to reconstruct 3D information of the space by estimating the depth value from the simulation of human eyes. Spatial restoration can be used as a means of location estimation in an indoor area, which is impossible to accomplish u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dbcbe4b0f5a23d77b3c8448b7fecb1
https://doi.org/10.1155/2018/5160543
https://doi.org/10.1155/2018/5160543
Publikováno v:
The Journal of Neuroscience. 36:10181-10197
During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits. Among the proteins that induce membrane dynamics, cell adhesion molecules are importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e443d2fd8c52040bdd704635b35d8329
https://doi.org/10.1523/jneurosci.0541-16.2016
https://doi.org/10.1523/jneurosci.0541-16.2016
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181257 (2017)
PLoS ONE, Vol 12, Iss 7, p e0181257 (2017)
V-set and transmembrane domain-containing protein 5 (Vstm5), a newly characterized small membrane glycoprotein, can induce membrane protrusions in various cells. Vstm5 can modulate both the position and complexity of central neurons by altering their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5d88bad51c4ffa59bfae9e3d3c9cb7
http://europepmc.org/articles/PMC5528877
http://europepmc.org/articles/PMC5528877