Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Kwang Pak"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
BackgroundA number of drugs are toxic to the cochlear sensory cells known as hair cells (HCs), resulting in hearing loss. Treatment with survival-promoting growth factors, antioxidants, and inhibitors of cell death pathways or proteinases have been s
Externí odkaz:
https://doaj.org/article/8e0472819a384f6ba20f33ba0505afa5
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Drug treatments for middle ear diseases are currently delivered systemically, or locally after opening the impermeable tympanic membrane (TM). We previously used bacteriophage display to discover novel peptides that are actively transported
Externí odkaz:
https://doaj.org/article/56e2881a31e34da0bfe898c7f13f9167
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Otitis media (OM) is one of the largest public health problems of children and has devastating impacts in developing countries. The substantial medical and human costs involved have led to research to understand the disease and improve treatment. Ani
Externí odkaz:
https://doaj.org/article/8bd559a083244478b2217748ea512e03
Autor:
Arwa Kurabi, Dong Gu Hur, Kwang Pak, Madeline Gibson, Nicholas J. G. Webster, Andrew Baird, Brian P. Eliceiri, Allen F. Ryan
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Otitis media (OM), the most common disease of childhood, is typically characterized by bacterial infection of the middle ear (ME). Prominent features of OM include hyperplasia of the ME mucosa, which transforms from a monolayer of simple squamous epi
Externí odkaz:
https://doaj.org/article/60527e3c4e484944810f0de33810404d
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Intracellular nucleotide binding and oligomerization domain (NOD) and Toll-like (TLR) receptors have emerged as pivotal sensors of infection. Both Nod1 and Nod2 contain a caspase activation and recruitment domain (CARD) that interacts with the adapto
Externí odkaz:
https://doaj.org/article/e63e86f4d66d4cee8b15e766331ebd8e
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Otitis media (OM), the most common childhood illness, can be caused by bacterial and/or viral infection. Hyperplasia of the middle ear (ME) mucosa is an important component of OM that contributes to its deleterious sequelae. Our previous research rev
Externí odkaz:
https://doaj.org/article/ef8c6a00eec149dfbfe8c973db2bb763
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
BackgroundPathogens of otitis media (OM) induce inflammatory responses in the middle ear (ME), characterized by mucosal hyperplasia, leukocyte infiltration, and inflammatory mediators, including arachidonic acid metabolites. We studied the role of th
Externí odkaz:
https://doaj.org/article/9bfa0b3ce3404c4aa3e73a3d57d8dc78
Autor:
Clara Draf, Taylor Wyrick, Eduardo Chavez, Kwang Pak, Arwa Kurabi, Anke Leichtle, Stefan Dazert, Allen F. Ryan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Introduction: Autophagy is a degradative pathway to safely break down and recycle dysfunctional cellular components. There is prior evidence of autophagy participation during hair cell (HC) damage. Our goal was to screen compounds targeting different
Externí odkaz:
https://doaj.org/article/6918f48268564cb98b229a767a618018
Publikováno v:
BMC Immunology, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background CD44 is a multifunctional molecule that plays major roles in both leukocyte recruitment and tissue proliferation. Since mucosal hyperplasia and leukocyte infiltration of the middle ear cavity are major features of otitis media, we
Externí odkaz:
https://doaj.org/article/08a393a4716d4be5ac7f845588d176a2
Autor:
Allen F. Ryan, Chanond A. Nasamran, Kwang Pak, Clara Draf, Kathleen M. Fisch, Nicholas Webster, Arwa Kurabi
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two
Externí odkaz:
https://doaj.org/article/fe85c2cdb1fe4698ac6ddc70645a4eaa