Zobrazeno 1 - 10
of 883
pro vyhledávání: '"Kwang‐Hyun Cho"'
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background The potential of microglia as a target for Alzheimer’s disease (AD) treatment is promising, yet the clinical and pathological diversity within microglia, driven by genetic factors, poses a significant challenge. Subtyping AD is
Externí odkaz:
https://doaj.org/article/3a125418e4df4c7bab43eecefa1d8ae8
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among molecules, making mathematical model-based quantitative analysis indispensable for its elucid
Externí odkaz:
https://doaj.org/article/f5994b3cfb014b99bcb241dd654e1828
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background A central challenge in biology is to discover a principle that determines individual phenotypic differences within a species. The growth rate is particularly important for a unicellular organism, and the growth rate under a certai
Externí odkaz:
https://doaj.org/article/4d72f2e8d8fd41998f0dac9cfab3f1f9
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108377- (2023)
Summary: Tumor suppressor p53 plays a pivotal role in suppressing cancer, so various drugs has been suggested to upregulate its function. However, drug resistance is still the biggest hurdle to be overcome. To address this, we developed a deep learni
Externí odkaz:
https://doaj.org/article/536f63c33ca74062b0e44e140b2f5d1e
Autor:
Dongkwan Shin, Kwang-Hyun Cho
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 4, Pp 692-705 (2023)
Abstract Cancer is caused by the accumulation of genetic alterations and therefore has been historically considered to be irreversible. Intriguingly, several studies have reported that cancer cells can be reversed to be normal cells under certain cir
Externí odkaz:
https://doaj.org/article/7edfa872f9b642fabe0b13cbefa9328f
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The underlying genetic networks of cells give rise to diverse behaviors known as phenotypes. Control of this cellular phenotypic diversity (CPD) may reveal key targets that govern differentiation during development or drug resistance in canc
Externí odkaz:
https://doaj.org/article/63f89068abba4fb0b44b9cdfae6d97fd
Publikováno v:
Advanced Science, Vol 10, Iss 24, Pp n/a-n/a (2023)
Abstract Accumulated genetic alterations in cancer cells distort cellular stimulus‐response (or input–output) relationships, resulting in uncontrolled proliferation. However, the complex molecular interaction network within a cell implicates a po
Externí odkaz:
https://doaj.org/article/c56d28d5d3eb40648a6c6d829bf93ee5
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
A network dynamics-based approach is used to screen for the therapeutic windows of drug combinations and explore the response of the p53 network to drugs in different patients and cell lines.
Externí odkaz:
https://doaj.org/article/7b10bae099274b7a836b61dd528ba480
Autor:
Keun-Woo Lee, So-Young Yeo, Jeong-Ryeol Gong, Ok-Jae Koo, Insuk Sohn, Woo Yong Lee, Hee Cheol Kim, Seong Hyeon Yun, Yong Beom Cho, Mi-Ae Choi, Sugyun An, Juhee Kim, Chang Ohk Sung, Kwang-Hyun Cho, Seok-Hyung Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Cancer associated fibroblasts are an important and highly heterogeneous component of the tumor microenvironment. Here the authors identify PRRX1 as a master transcription factor determining a fibroblast lineage with myofibroblastic phenotype, associa
Externí odkaz:
https://doaj.org/article/f8a3db8d4f924585bc63f79a50a42110
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The organizational principles of the community architecture of human brain networks are still mostly unknown. Here, we found that brain networks have a moderate degree of community segregation but are specifically organized to achieve high c
Externí odkaz:
https://doaj.org/article/2165f57aed8641b5a07a55f5945cab4f