Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kwan Yi Chu"'
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101023- (2020)
Objective: Investigations of autophagy in β-cells have usually focused on its homeostatic function. More dynamic roles in inhibiting glucose-stimulated insulin secretion (GSIS), potentially involving remodelling of cellular lipids, have been suggest
Externí odkaz:
https://doaj.org/article/cd418bc34d88406ab306ca4bce735f48
Autor:
Gemma L. Pearson, Natalie Mellett, Kwan Yi Chu, Ebru Boslem, Peter J. Meikle, Trevor J. Biden
Publikováno v:
Molecular Metabolism, Vol 5, Iss 6, Pp 404-414 (2016)
Objective: Glucose promotes lipid remodelling in pancreatic β-cells, and this is thought to contribute to the regulation of insulin secretion, but the metabolic pathways and potential signalling intermediates have not been fully elaborated. Methods:
Externí odkaz:
https://doaj.org/article/e7690088ab7b4cae98abb75ccb8be222
Autor:
Liam O’Reilly, Natalie A. Mellet, Peter J. Meikle, Trevor J. Biden, Kwan Yi Chu, Clarissa Bartley
Publikováno v:
Journal of Biological Chemistry. 294:1218-1229
Autophagy is critical for maintaining cellular function via clearance of excess nutrients and damaged organelles. In pancreatic β-cells, it helps counter the endoplasmic reticulum (ER) stress that impairs insulin secretory capacity during Type 2 dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88067899eb134c72b58eed9858752e69
https://doi.org/10.1074/jbc.ra118.004833
https://doi.org/10.1074/jbc.ra118.004833
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 40, Iss, Pp 101023-(2020)
Molecular Metabolism, Vol 40, Iss, Pp 101023-(2020)
Objective Investigations of autophagy in β-cells have usually focused on its homeostatic function. More dynamic roles in inhibiting glucose-stimulated insulin secretion (GSIS), potentially involving remodelling of cellular lipids, have been suggeste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a74eab2aba550a4162f289a5042b95
https://pubmed.ncbi.nlm.nih.gov/32504884
https://pubmed.ncbi.nlm.nih.gov/32504884
Publikováno v:
Trends in Endocrinology & Metabolism. 25:389-398
Failure of the unfolded protein response (UPR) to maintain optimal folding of pro-insulin in the endoplasmic reticulum (ER) leads to unresolved ER stress and β cell death. This contributes not only to some rare forms of diabetes, but also to type 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a85e3caf0122b76e8b27bce27ceed4
https://doi.org/10.1016/j.tem.2014.02.003
https://doi.org/10.1016/j.tem.2014.02.003
Autor:
James Cantley, Kwan Yi Chu, Casey C. Cosner, Natalie A. Mellett, Paul Helquist, Aimee Davenport, Peter J. Meikle, Gemma L. Pearson, Trevor J. Biden, Pauline Bourbon
Publikováno v:
Diabetologia. 57:129-139
AIMS/HYPOTHESIS: Lipolytic breakdown of endogenous lipid pools in pancreatic beta cells contributes to glucose-stimulated insulin secretion (GSIS) and is thought to be mediated by acute activation of neutral lipases in the amplification pathway. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96c187c432cb9952c1d2ce393c5da93
https://doi.org/10.1007/s00125-013-3083-x
https://doi.org/10.1007/s00125-013-3083-x
Autor:
James D. Johnson, Gareth E. Lim, Shernaz X. Bamji, Nicole M. Templeman, Ali Asadi, José Diego Botezelli, Kwan-Yi Chu, G. Stefano Brigidi, Susanne M. Clee, Bradford G. Hoffman, Xiaoke Hu, Arya E. Mehran, Timothy J. Kieffer
Publikováno v:
Cell Metabolism. 16(6):723-737
Summary Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether insulin causes these phenomena or is a compensatory response has remained unsettled for decades. We examined the role of insulin hypersecretion in diet-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5453a2e8182047c229e5d2853a4850a
Publikováno v:
Islets. 3:155-165
Hyperglycemia can result from a relative or absolute lack of functional insulin secreted by the pancreatic β-cells. Prohormone processing enzymes play an essential role in the secretion of mature and fully functional insulin. Defects in insulin proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782cb6858f90098e929a09bbf042f425
https://doi.org/10.4161/isl.3.4.15767
https://doi.org/10.4161/isl.3.4.15767
Publikováno v:
Journal of Biological Chemistry. 285:32606-32615
Elevated extracellular lipids, such as the free fatty acid palmitate, can induce pancreatic beta cell endoplasmic reticulum (ER) stress and apoptosis, thereby contributing to the initiation and progression of type 2 diabetes. ATP-citrate lyase (ACLY)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76dc4443f79ac7ca6519afaed811375
https://doi.org/10.1074/jbc.m110.157172
https://doi.org/10.1074/jbc.m110.157172
Autor:
Po Sing Leung, Leonid Motin, Chen Chen, Sai Wang Seto, Lai Shan Au, Ya Tuo, Kwan Yi Chu, Yiu Wa Kwan, Qianni Cheng
Publikováno v:
American Journal of Physiology-Cell Physiology. 298:C313-C323
Hyperglycemia-associated glucotoxicity induces β-cell apoptosis but the underlying mechanisms are unknown. Interestingly, prolonged exposure to high glucose upregulates the expression and function of the renin-angiotensin system (RAS). We hypothesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855c05f81811ce3f1a602262912fe27b
https://doi.org/10.1152/ajpcell.00575.2008
https://doi.org/10.1152/ajpcell.00575.2008