Výsledky vyhledávání

Akademický článek

Novel Oxidative Stress Biomarkers with Risk Prognosis Values in Heart Failure

Autor: Mei Li Ng, Xu Ang, Kwan Yi Yap, Jun Jie Ng, Eugene Chen Howe Goh, Benjamin Bing Jie Khoo, Arthur Mark Richards, Chester Lee Drum

Publikováno v: Biomedicines, Vol 11, Iss 3, p 917 (2023)

Oxidative stress (OS) is mediated by reactive oxygen species (ROS), which in cardiovascular and other disease states, damage DNA, lipids, proteins, other cellular and extra-cellular components. OS is both initiated by, and triggers inflammation, card

Externí odkaz: https://doaj.org/article/f381f22715b54683a0713195f6dd96df

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Akademický článek

Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding

Autor: Kwan Yi Chu, Natalie Mellet, Le May Thai, Peter J. Meikle, Trevor J. Biden

Publikováno v: Molecular Metabolism, Vol 40, Iss , Pp 101023- (2020)

Objective: Investigations of autophagy in β-cells have usually focused on its homeostatic function. More dynamic roles in inhibiting glucose-stimulated insulin secretion (GSIS), potentially involving remodelling of cellular lipids, have been suggest

Externí odkaz: https://doaj.org/article/cd418bc34d88406ab306ca4bce735f48

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Akademický článek

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

Autor: Gemma L. Pearson, Natalie Mellett, Kwan Yi Chu, Ebru Boslem, Peter J. Meikle, Trevor J. Biden

Publikováno v: Molecular Metabolism, Vol 5, Iss 6, Pp 404-414 (2016)

Objective: Glucose promotes lipid remodelling in pancreatic β-cells, and this is thought to contribute to the regulation of insulin secretion, but the metabolic pathways and potential signalling intermediates have not been fully elaborated. Methods:

Externí odkaz: https://doaj.org/article/e7690088ab7b4cae98abb75ccb8be222

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