Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kwan Y. Hui"'
Autor:
Alla Gustchina, David J. Powell, John Kay, Kwan Y. Hui, Alexander Zdanov, Jukka Kervinen, Jacek Lubkowski, Deepa Bhatt, Alexander Wlodawer, Ben M. Dunn
Publikováno v:
Protein Science. 7:2314-2323
One of the major problems encountered in antiviral therapy against AIDS is the emergence of viral variants that exhibit drug resistance. The sequences of proteases (PRs) from related retroviruses sometimes include, at structurally equivalent position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d097ffdaa35f8f56a38c06a16850e8
https://doi.org/10.1002/pro.5560071108
https://doi.org/10.1002/pro.5560071108
Autor:
Paul A. Hyslop, Joseph A. Jakubowski, Ruth M. Kramer, Kwan Y. Hui, Barbara G. Utterback, Edda F. Roberts
Publikováno v:
Journal of Biological Chemistry. 270:14816-14823
The thrombin receptor agonist peptide SFLLRN was less effective than thrombin in eliciting the liberation of arachidonic acid and the generation of thromboxane A2 by human platelets. We found that while SFLLRN evokes an initial transient increase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ec4d6c7e0ba142bad14c7e054a0882
https://doi.org/10.1074/jbc.270.24.14816
https://doi.org/10.1074/jbc.270.24.14816
Autor:
Alexander Wlodawer, Alla Gustchina, Ludmila Reshetnikova, Jacek Lubkowski, Alexander Zdanov, Kwan Y. Hui, Eddie L. Angleton, William G. Farmerie, Maureen M. Goodenow, Deepa Bhatt, Li Zhang, Ben M. Dunn
Publikováno v:
Nature Structural & Molecular Biology. 2:480-488
The crystal structure of a recombinant form of the proteinase encoded by the feline immunodeficiency virus (FIV PR) has been solved at 2 A resolution and refined to an R-factor of 0.148. The refined structure includes a peptidomimetic, statine-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c0c03a568c465e9a3091d8c9d7882e
https://doi.org/10.1038/nsb0695-480
https://doi.org/10.1038/nsb0695-480
Publikováno v:
FEBS Letters. 327:355-360
Through a series of synthetic model peptides, we have examined the structural requirements of the P2 and P3 residues in statine-based HIV protease (PR) inhibitors. Results agree with the general observations that, the more bulky the P3 aromatic hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf80a0d6e5180365db2426c3c3652901
https://doi.org/10.1016/0014-5793(93)81020-z
https://doi.org/10.1016/0014-5793(93)81020-z
Publikováno v:
Biochemical and Biophysical Research Communications. 184:790-796
A site-specific proteolytically generated neoamino terminus of the thrombin receptor having a sequence SFLLRNPNDKYEPF- has been reported to be a functional ligand of the receptor. This discovery raises question on the precise structural requirements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa7c084705484a84ec9d3d8df2d9d65
https://doi.org/10.1016/0006-291x(92)90659-9
https://doi.org/10.1016/0006-291x(92)90659-9
Autor:
Randall M. Zusman, David A. Schoenfeld, Kwan Y. Hui, Jürg Nussberger, Edgar Haber, Donna M. Christensen, Joy Higgins, William D. Carlson
Publikováno v:
American Journal of Hypertension, vol. 7, no. 4 Pt 1, pp. 295-301
The hemodynamic and humoral effects of the specific human renin inhibitor R-PEP-27 were studied in six normal human subjects on low and high sodium intake diets. An intravenous infusion of R-PEP-27 (0.5 to 16 μg/min/kg body wt) reduced blood pressur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35366e18199362756054bd55bb10d11b
https://pubmed.ncbi.nlm.nih.gov/8031544
https://pubmed.ncbi.nlm.nih.gov/8031544
Autor:
Theresa Gygi, William M. Shannon, Bonnie J. Bowdon, Kathy A. Keith, Kwan Y. Hui, Mei-Huei T. Lai, Joseph V. Manetta
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 5(11)
Synthetic peptides described as dog renin inhibitors were found to effectively inhibit the aspartyl protease of human immunodeficiency virus (HIV). The selection of oligopeptides for the HIV protease inhibition study was based on 1) the current strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32595667ac4416e8ba94ecce5914db77
https://pubmed.ncbi.nlm.nih.gov/1868985
https://pubmed.ncbi.nlm.nih.gov/1868985
Angiotensin I and II disappear completely from circulating blood within 48 hours after binephrectomy
Autor:
Dominique Evéquoz, Jürg Nussberger, Jean-Pierre Flückiger, Hans R. Brunner, Bernard Waeber, Kwan Y. Hui
Publikováno v:
Journal of Hypertension. 9:S232
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d7d7eeb7c2f2d2449cab1f78a4bfc9
https://doi.org/10.1097/00004872-199112000-00099
https://doi.org/10.1097/00004872-199112000-00099
Publikováno v:
Hypertension. 14:480-487
Pro-His-Pro-Phe-His-Statine-Ile-Phe-NH2 (R-Pep-27), a potent renin inhibitory peptide, was infused into the conscious, sodium-depleted Macaca fascicularis at doses of 0, 0.1, 1, 4, 16, and 32 micrograms/kg/min for 10 minutes. At all doses greater tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69b7c4815e5ae2b3427fae7bc536a7a
https://doi.org/10.1161/01.hyp.14.5.480
https://doi.org/10.1161/01.hyp.14.5.480
Publikováno v:
Molecular Immunology. 20:521-527
Fibrin-specific antibodies have been produced in rabbits which were immunized with synthetic peptides. Specificity against human fibrin monomer was achieved because the synthetic peptide haptens were derived from sites unique to fibrin as compared wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dd103cdbbc6fded77c3866306b5109
https://doi.org/10.1016/0161-5890(83)90090-1
https://doi.org/10.1016/0161-5890(83)90090-1