Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kwan H Cheng"'
Publikováno v:
Macromol, Vol 3, Iss 4, Pp 805-827 (2023)
The disruption of cell membranes by tau and amylin oligomers is linked to amyloid diseases such as Alzheimer’s and diabetes, respectively. The recent studies suggest that misfolded tau and amylin can form neurotoxic hetero-oligomers that are struct
Externí odkaz:
https://doaj.org/article/0b9657e898704dc08cdc21aa9d7c864d
Autor:
Luthary Segura, Natalia Santos, Rafael Flores, Donald Sikazwe, Miles McGibbon, Vincent Blay, Kwan H. Cheng
Publikováno v:
Molecules, Vol 29, Iss 12, p 2818 (2024)
Intracellular tau fibrils are sources of neurotoxicity and oxidative stress in Alzheimer’s. Current drug discovery efforts have focused on molecules with tau fibril disaggregation and antioxidation functions. However, recent studies suggest that me
Externí odkaz:
https://doaj.org/article/240ab94f2ab64bc6b0ba6644c8acdd24
Publikováno v:
Molecules, Vol 29, Iss 3, p 740 (2024)
The molecular events of protein misfolding and self-aggregation of tau and amylin are associated with the progression of Alzheimer’s and diabetes, respectively. Recent studies suggest that tau and amylin can form hetero-tau-amylin oligomers. Those
Externí odkaz:
https://doaj.org/article/bfc0ffeabd52480d83f5ce974c4b30c5
Publikováno v:
Molecules, Vol 28, Iss 10, p 4191 (2023)
The aggregation of human Islet Amyloid Polypeptide (hIAPP) on cell membranes is linked to amyloid diseases. However, the physio-chemical mechanisms of how these hIAPP aggregates trigger membrane damage are unclear. Using coarse-grained and all-atom m
Externí odkaz:
https://doaj.org/article/dd57b8dcc46e4d97ac2c6418887bcc16
Publikováno v:
Molecules, Vol 28, Iss 5, p 2319 (2023)
In search of synthetically accessible open-ring analogs of PD144418 or 5-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)-3-(p-tolyl)isoxazole, a highly potent sigma-1 receptor (σ1R) ligand, we herein report the design and synthesis of sixteen arylated acy
Externí odkaz:
https://doaj.org/article/0d3966f001dd4b0cb8114de169c7bf06
Publikováno v:
Membranes, Vol 12, Iss 11, p 1098 (2022)
The self-aggregation of tau, a microtubule-binding protein, has been linked to the onset of Alzheimer’s Disease. Recent studies indicate that the disordered tau aggregates, or oligomers, are more toxic than the ordered fibrils found in the intracel
Externí odkaz:
https://doaj.org/article/ef5b02faf49c4440aa865da8d341bcf8
Publikováno v:
Data in Brief, Vol 30, Iss , Pp 105496- (2020)
The structural conformations of phospholipids and cholesterol in phase-separated lipid domains were determined by surface area, transverse density profile, and lipid acyl chain orientational parameter calculations. Binding kinetics and characterizati
Externí odkaz:
https://doaj.org/article/d397389abb9e4fb7bfeda242fe944546
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 658-672 (2016)
This data article supports the research article entitled “Maximally Asymmetric Transbilayer Distribution of Anionic Lipids Alters the Structure and interaction with Lipids of an Amyloidogenic Protein Dimer Bound to the Membrane Surface” [1]. We d
Externí odkaz:
https://doaj.org/article/207fb4655ff040ecbba5822737e4a1c7
Autor:
Maher A. Dayeh, George Livadiotis, Farzan Aminian, Kwan H. Cheng, James L. Roberts, Nikita Viswasam, Saber Elaydi
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2905 (2020)
The association between plasma cholesterol levels and the development of dementia continues to be an important topic of discussion in the scientific community, while the results in the literature vary significantly. We study the effect of reducing ox
Externí odkaz:
https://doaj.org/article/830635597a7d4d4d85fb7c5f6ee2aae5
Publikováno v:
Biophysical Chemistry. 296:106993
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa0c42df86b8fc49dc224ef0c7480b5c
https://doi.org/10.1016/j.bpc.2023.106993
https://doi.org/10.1016/j.bpc.2023.106993