Výsledky vyhledávání - "Kwan Cheol Pak"

Akademický článek

Development of a Web Application for Simulating Plasma Drug Concentrations in Patients with Zolpidem Intoxication

Autor: Hwa Jun Cha, Sungpil Han, Kwan Cheol Pak, Hyungsub Kim

Publikováno v: Pharmaceutics, Vol 16, Iss 5, p 689 (2024)

Zolpidem is a widely prescribed hypnotic Z-drug used to treat short-term insomnia. However, a growing number of individuals intentionally overdose on these drugs. This study aimed to develop a predictive tool for physicians to assess patients with zo

Externí odkaz: https://doaj.org/article/8ce2226814d243f596bef5c76b42b9e0

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Whole-Body Physiologically Based Pharmacokinetic Modeling of Trastuzumab and Prediction of Human Pharmacokinetics

Autor: Sang Mun Bae, Hyeong-Seok Lim, SeokKyu Yoon, Dong-Jun Bae, Ae-Kyung Hwang, Kwan Cheol Pak, Sang-Yeob Kim

Publikováno v: Journal of pharmaceutical sciences. 108(6)

In the present study, we evaluated the pharmacokinetics (PK) of trastuzumab and sought to predict human PK based on animal studies, through the use of optical imaging and a whole-body physiologically based pharmacokinetic (WB-PBPK) modeling approach.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8660886c0c0a917de2012559bf9e96c1
https://pubmed.ncbi.nlm.nih.gov/30716331

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Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline

Autor: Kyun-Seop Bae, Ki Soon Kim, Seung-eun Choi, Hyeong-Seok Lim, Sunae Ryu, Kwan Cheol Pak, Hee Youn Choi, Ara Koh

Publikováno v: Journal of clinical pharmacology. 59(4)

Amitriptyline is a tricyclic antidepressant that is metabolized mainly by CYP2C19 and CYP2D6 enzymes. Higher plasma levels of amitriptyline and its active metabolite, nortriptyline, are associated with an increased risk of adverse events including an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf79dbec6ff3cff5bdb49a9c77f5e975
https://pubmed.ncbi.nlm.nih.gov/30452773

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Akademický článek

Development of a Web Application for Simulating Plasma Drug Concentrations in Patients with Zolpidem Intoxication.

Autor: Cha, Hwa Jun^1,2 (AUTHOR) clex9604@catholic.ac.kr, Han, Sungpil^1,2 (AUTHOR) shan@catholic.ac.kr, Pak, Kwan Cheol³ (AUTHOR) kcpak4175@yuhan.co.kr, Kim, Hyungsub⁴ (AUTHOR) hkim@eulji.ac.kr

Publikováno v: Pharmaceutics. May2024, Vol. 16 Issue 5, p689. 12p.

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