Výsledky vyhledávání - "Kwame Twumasi-Boateng"

Akademický článek

Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines.

Autor: Spencer D Martin, Scott D Brown, Darin A Wick, Julie S Nielsen, David R Kroeger, Kwame Twumasi-Boateng, Robert A Holt, Brad H Nelson

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155189 (2016)

Due to advances in sequencing technology, somatically mutated cancer antigens, or neoantigens, are now readily identifiable and have become compelling targets for immunotherapy. In particular, neoantigen-targeted vaccines have shown promise in severa

Externí odkaz: https://doaj.org/article/e6254d0f66804202a0022687d5592a85

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Akademický článek

Oncolytic vesicular stomatitis virus expressing interferon-σ has enhanced therapeutic activity

Autor: Marie-Claude Bourgeois-Daigneault, Dominic Guy Roy, Theresa Falls, Kwame Twumasi-Boateng, Lauren Elizabeth St-Germain, Monique Marguerie, Vanessa Garcia, Mohammed Selman, Victoria Ann Jennings, Jessica Pettigrew, Sally Amos, Jean-Simon Diallo, Brad Nelson, John Cameron Bell

Publikováno v: Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)

Oncolytic viruses are known to stimulate the antitumor immune response by specifically replicating in tumor cells. This is believed to be an important aspect of the durable responses observed in some patients and the field is rapidly moving toward im

Externí odkaz: https://doaj.org/article/463442ece69740ee816ed48a9a899fe0

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Akademický článek

The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans.

Autor: Dena H S Block, Kwame Twumasi-Boateng, Hae Sung Kang, Jolie A Carlisle, Alexandru Hanganu, Ty Yu-Jen Lai, Michael Shapira

Publikováno v: PLoS Genetics, Vol 11, Iss 5, p e1005265 (2015)

GATA transcription factors play critical roles in cellular differentiation and development. However, their roles in mature tissues are less understood. In C. elegans larvae, the transcription factor ELT-2 regulates terminal differentiation of the int

Externí odkaz: https://doaj.org/article/cd2171888ea24c8a9d070ce8268bc51e

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Akademický článek

Dissociation of immune responses from pathogen colonization supports pattern recognition in C. elegans.

Autor: Kwame Twumasi-Boateng, Michael Shapira

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35400 (2012)

Caenorhabditis elegans has been used for over a decade to characterize signaling cascades controlling innate immune responses. However, what initiates these responses in the worm has remained elusive. To gain a better understanding of the initiating

Externí odkaz: https://doaj.org/article/8b276ed1bf8b4d24a8484682b1eb4c7b

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