Single-cell analysis of human airway epithelium identifies cell type-specific responses to Aspergillus and Coccidioides .

Autor: Harding AT; Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge MA.; Department of Microbiology, Harvard Medical School, Cambridge MA., Crossen AJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Reedy JL; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Basham KJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Hepworth OW; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Zhang Y; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA USA., Shah VS; Harvard Stem Cell Institute, Cambridge, MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Harding HB; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Surve MV; Harvard Stem Cell Institute, Cambridge, MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Simaku P; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kwaku GN; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Jensen KN; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Otto Y; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA., Ward RA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Thompson GR; Division of Infectious Diseases, and Departments of Internal Medicine and Medical Microbiology and Immunology, University of California-Davis, Sacramento, CA, USA., Klein BS; Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Rajagopal J; Harvard Stem Cell Institute, Cambridge, MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Sen P; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Transplant, Oncology, and Immunocompromised Host Group, Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Haber AL; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA USA., Vyas JM; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 13. Date of Electronic Publication: 2024 Sep 13.

Host innate immune systems gather intel on invading microbes via pathogen-derived extracellular vesicles.

Autor: Kwaku GN; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Ward RA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Vyas JM; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Harding HB; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Publikováno v: Extracellular vesicle [Extracell Vesicle] 2024 Jun; Vol. 3. Date of Electronic Publication: 2024 May 17.

Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING.

Autor: Brown Harding H; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Kwaku GN; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Reardon CM; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Khan NS; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Zamith-Miranda D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA., Zarnowski R; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Department of Microbiology and Immunology, University of Wisconsin Madison, Madison, WI, USA., Tam JM; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Bohaen CK; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands., Richey L; Tufts Comparative Medicine Services, Tufts University, Boston, MA, USA., Mosallanejad K; Division of Gastroenterology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Crossen AJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Reedy JL; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Ward RA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Vargas-Blanco DA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Basham KJ; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Bhattacharyya RP; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nett JE; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Department of Microbiology and Immunology, University of Wisconsin Madison, Madison, WI, USA., Mansour MK; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., van de Veerdonk FL; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands., Kumar V; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; University Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, the Netherlands.; Nitte University Centre for Science Education and Research, Medical Sciences Complex, Mangaluru, India., Kagan JC; Division of Gastroenterology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Andes DR; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Department of Microbiology and Immunology, University of Wisconsin Madison, Madison, WI, USA., Nosanchuk JD; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA., Vyas JM; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. jvyas@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. jvyas@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. jvyas@mgh.harvard.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Jan; Vol. 9 (1), pp. 95-107. Date of Electronic Publication: 2024 Jan 02.