Zobrazeno 1 - 10 of 59 pro vyhledávání: '"Kwai Wa Cheng"'
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Akademický článek
Simultaneous submission of seven CTSA proposals: UM1, K12, R25, T32-predoctoral, T32-postdoctoral, and RC2: strategies, evaluation, and lessons learned
Autor: Carolina Lema, Kwai Wa Cheng, Delanderia M. Anderson, Charles C. Miller, Daniel D. Karp, David D. McPherson, Satya Sree N. Kolar
Publikováno v: Journal of Clinical and Translational Science, Vol 8 (2024)
Translation is the process of turning observations in the research laboratory, clinic, and community into interventions that improve people’s health. The Clinical and Translational Science Awards (CTSA) program is a National Center for Advancing Tr
Externí odkaz: https://doaj.org/article/3d37b04bedba454e96dca947a8cdafad
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Data from Amplification of MDS1/EVI1 and EVI1, Located in the 3q26.2 Amplicon, Is Associated with Favorable Patient Prognosis in Ovarian Cancer
Autor: Gordon B. Mills, Joe W. Gray, David Fishman, Karen Smith-McCune, Wen-Lin Kuo, Karen Lu, Jinsong Liu, John Lahad, Kwai Wa Cheng, Yasuhisa Nakayama, Meera Nanjundan
Increased copy number involving chromosome 3q26 is a frequent and early event in cancers of the ovary, lung, head and neck, cervix, and BRCA1 positive and basal breast cancers. The p110α catalytic subunit of phosphoinositide-3-kinase (PI3KCA) and pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df14dd4a1d37ef0769363bf609e9f1f
https://doi.org/10.1158/0008-5472.c.6495870
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6
Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress
Autor: Kwai Wa Cheng, Mark S. Carey, Joe W. Gray, Roshan Agarwal, Gordon B. Mills, Shreya Mitra, Ju Seog Lee
Publikováno v: EMBO Molecular Medicine
Cancer cells are metabolically stressed during tumour progression due to limited tumour vascularity and resultant nutrient, growth factor and oxygen deficiency that can induce cell death and inhibit tumour growth. We demonstrate that Rab25, a small G
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fece8e7d119752a9d3cfd6842bda468
http://europepmc.org/articles/PMC3306554
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7
Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models
Autor: Ju Seog Lee, Eun Sung Park, Jiyong Liang, Yiling Lu, Catherine Nguyen-Charles, Jae Ho Cheong, Jaffer A. Ajani, Jennifer B. Dennison, Kwai Wa Cheng, Gordon B. Mills, Hassan Hall, Murali Ravoori, Dimitra Tsavachidou, Dong Zhang, Vikas Kundra, Waun Ki Hong
Publikováno v: Molecular Cancer Therapeutics. 10:2350-2362
Tumor cell proliferation requires both growth signals and sufficient cellular bioenergetics. The AMP-activated protein kinase (AMPK) pathway seems dominant over the oncogenic signaling pathway suppressing cell proliferation. This study investigated t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad612311e2484db64edbc8689ca35124
https://doi.org/10.1158/1535-7163.mct-11-0497
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8
FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5
Autor: Jiayi Zhou, Kwai Wa Cheng, Jingxin Ding, Yingtao Liu, Yan Huang, Yinhua Yu, Youji Feng, Hongyan Jin
Publikováno v: Endocrine Related Cancer. 18:13-26
Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the express
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6234d26dc961a558285bd87c8ce8797f
https://doi.org/10.1677/erc-09-0308
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9
The Emerging Role of the RAB25 Small GTPase in Cancer
Autor: Kwai Wa Cheng, Gordon B. Mills, Igor Jurisica, Roshan Agarwal
Publikováno v: Traffic. 10:1561-1568
RAB25, a member of the rat sarcoma (RAS) family of small GTPase, has been implicated in the pathophysiology of ovarian, breast and other cancers. Its role in endosomal transport and recycling of cell-surface receptors and signaling proteins presents
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2a43550a13fbd8ea0796f318cdf410
https://doi.org/10.1111/j.1600-0854.2009.00969.x
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10
Amplification of MDS1/EVI1 and EVI1, Located in the 3q26.2 Amplicon, Is Associated with Favorable Patient Prognosis in Ovarian Cancer
Autor: John P. Lahad, Karen H. Lu, Gordon B. Mills, Jinsong Liu, Joe W. Gray, Kwai Wa Cheng, Yasuhisa Nakayama, Meera Nanjundan, David A. Fishman, Wen-Lin Kuo, Karen Smith-McCune
Publikováno v: Cancer Research. 67:3074-3084
Increased copy number involving chromosome 3q26 is a frequent and early event in cancers of the ovary, lung, head and neck, cervix, and BRCA1 positive and basal breast cancers. The p110α catalytic subunit of phosphoinositide-3-kinase (PI3KCA) and pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc378ada8bef72d0fe8b3f134a2aef61
https://doi.org/10.1158/0008-5472.can-06-2366
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