Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kwabena B. Duah"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
O’Keefe et al. investigate the integration of type III single-pass transmembrane proteins targeted to the ER and examine the roles of the ER membrane complex, Sec61 complex and signal recognition particle receptor. As a result, the authors propose
Externí odkaz:
https://doaj.org/article/5c449021283a45d288dc2d9c2bd63056
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of prote
Externí odkaz:
https://doaj.org/article/84a590a1a842429faa233bc88b29e96b
Autor:
Sarah O’Keefe, Pratiti Bhadra, Kwabena B. Duah, Guanghui Zong, Levise Tenay, Lauren Andrews, Hayden Schneider, Ashley Anderson, Zhijian Hu, Hazim S. Aljewari, Belinda S. Hall, Rachel E. Simmonds, Volkhard Helms, Stephen High, Wei Q. Shi
Publikováno v:
Molecules, Vol 27, Iss 14, p 4419 (2022)
The plant-derived macrocyclic resin glycoside ipomoeassin F (Ipom-F) binds to Sec61α and significantly disrupts multiple aspects of Sec61-mediated protein biogenesis at the endoplasmic reticulum, ultimately leading to cell death. However, extensive
Externí odkaz:
https://doaj.org/article/49403f4f406c4963bef757e4b156aeea
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
The heterotrimeric Sec61 complex is a major site for the biogenesis of transmembrane proteins (TMPs), accepting nascent TMP precursors that are targeted to the endoplasmic reticulum (ER) by the signal recognition particle (SRP). Unlike most single-sp
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein entry
Autor:
Yuchun Du, Joong Sup Shim, Kwabena B Duah, Lauren E Andrews, Zhijian Hu, Wei Shi, Lucas Whisenhunt, Sarah O'Keefe, Stephen High, Jianhong Zhou, Guanghui Zong
Publikováno v:
The Journal of Organic Chemistry
Two new ring-size-varying analogues (2 and 3) of ipomoeassin F were synthesized and evaluated. Improved cytotoxicity (IC50: from 1.8 nM) and in vitro protein translocation inhibition (IC50: 35 nM) derived from ring expansion imply that the binding po
Autor:
Guanghui Zong, Kwabena B Duah, Peristera Roboti, Stephen High, Sarah O'Keefe, Hayden O. Schneider, Wei Shi
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (VoR) Version of Record
bioRxiv
article-version (status) pre
article-version (number) 1
In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2, the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural pr