The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity

Autor: Ebetino, FH, Ebetino, F, Lundy, M, Kwaasi, AA, Dunford, J, Duan, X, Triffitt, J, Mazur, A, Jeans, G, Barnett, BL, Russell, RG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e98ab013427e18ca57b3e61fcd3c743c
https://ora.ox.ac.uk/objects/uuid:a85ebc05-7055-4ad9-84b0-8ad7e3cffb56

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

Autor: Lawson MA; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Ebetino FH; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK.; Department of Chemistry, University of Rochester, Rochester, NY, USA., Mazur A; TWI Chem LLC, Mason, OH, USA., Chantry AD; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Paton-Hough J; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Evans HR; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Lath D; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Tsoumpra MK; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Lundy MW; Department of Anatomy and Cell Biology, Indiana University, Indianapolis, IN, USA., Dobson RL; Procter & Gamble, Mason, OH, USA., Quijano M; Procter & Gamble, Mason, OH, USA., Kwaasi AA; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Dunford JE; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Duan X; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Triffitt JT; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Jeans G; Procter & Gamble, Mason, OH, USA., Russell RGG; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK.

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2017 Sep; Vol. 32 (9), pp. 1860-1869. Date of Electronic Publication: 2017 Apr 21.

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

Autor: Dunford JE; Structural Genomics Consortium, The Botnar Research Centre, University of Oxford, Oxford, United Kingdom. james.dunford@ndos.ox.ac.uk, Kwaasi AA, Rogers MJ, Barnett BL, Ebetino FH, Russell RG, Oppermann U, Kavanagh KL

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2008 Apr 10; Vol. 51 (7), pp. 2187-95. Date of Electronic Publication: 2008 Mar 08.