The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

Autor: Tsoumpra, MK, Muniz, JR, Barnett, BL, Kwaasi, AA, Pilka, ES, Kavanagh, KL, Evdokimov, A, Walter, RL, Von Delft, F, Ebetino, FH, Oppermann, U, Russell, RG, Dunford, JE

Publikováno v: Bone. 81:478-486

Farnesyl pyrophosphate synthase (FPPS) is the major molecular target of nitrogen-containing bisphosphonates (N-BPs), used clinically as bone resorption inhibitors. We investigated the role of threonine 201 (Thr201) and tyrosine 204 (Tyr204) residues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c8d0c54a55e1f70510dcdc6567878dfa

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase

Autor: Dunford, JE, Pilka, E, Kwaasi, AA, Evdokimov, A, Barnett, BL, Oppermann, U, Ebetino, FH, Russell, RG, Kavanagh, KL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6f9df745b4bd4eae9835f76807c8a46a
https://ora.ox.ac.uk/objects/uuid:c5e9b39b-4963-4765-9a21-f89e61441cac

RAGE-mediated neutrophil dysfunction is evoked by advanced glycation end products (AGEs)

Autor: Collison, Ks, Parhar, Rs, Saleh, Ss, Meyer, Bf, Kwaasi, Aa, Muhammad Hammami, Schmidt, Am, Stern, Dm, Al-Mohanna, Fa

Publikováno v: Scopus-Elsevier
Web of Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::681dd001f26b0f9be4bfccaf94361ed4
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036521604&partnerID=MN8TOARS

Characterisation of antigens and allergens of the date palm (Phoenix dactylifera L.)

Autor: Kwaasi, Aaron Alfred Assah

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341829

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

Autor: Lawson MA; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Ebetino FH; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK.; Department of Chemistry, University of Rochester, Rochester, NY, USA., Mazur A; TWI Chem LLC, Mason, OH, USA., Chantry AD; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Paton-Hough J; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Evans HR; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Lath D; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Tsoumpra MK; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Lundy MW; Department of Anatomy and Cell Biology, Indiana University, Indianapolis, IN, USA., Dobson RL; Procter & Gamble, Mason, OH, USA., Quijano M; Procter & Gamble, Mason, OH, USA., Kwaasi AA; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Dunford JE; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Duan X; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Triffitt JT; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Jeans G; Procter & Gamble, Mason, OH, USA., Russell RGG; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK.

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2017 Sep; Vol. 32 (9), pp. 1860-1869. Date of Electronic Publication: 2017 Apr 21.