Zobrazeno 1 - 10 of 255 pro vyhledávání: '"Kw Kohn"'
1
DNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate)
Autor: Kw Kohn, Massimo Broggini, W. B. Mattes, Maurizio D'Incalci, Mauro Ponti, Ja Hartley
Publikováno v: British Journal of Cancer
The DNA damage and the sequence specificity of guanine-N7 alkylation produced by the novel, positively charged, antineoplastic agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate) and its uncharged tertiary amine a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e72433bc8e34868912fab3ae8670ff
https://doi.org/10.1038/bjc.1990.53
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2
DNA cross-linking responses of human malignant glioma cell strains to chloroethylnitrosoureas, cisplatin, and diaziquone
Autor: Sariban E, Kw, Kohn, Zlotogorski C, Laurent G, Maurizio D'Incalci, Rd, Day R., Bh, Smith, Pl, Kornblith, Lc, Erickson
Publikováno v: Europe PubMed Central
Cell strains derived by culture of malignant glioma (astrocytoma grade III-IV) surgical specimens were tested for the production of DNA interstrand cross-links (ISC) and DNA-protein cross-links following treatment in vitro with 1-(2-chloroethyl)-1-ni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::05fe29869441c5ed04542e8b84b50ea5
https://pubmed.ncbi.nlm.nih.gov/3038305
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3
DNA alkali-labile sites induced by incorporation of 5-aza-2'-deoxycytidine into DNA of mouse leukemia L1210 cells
Autor: Maurizio D'Incalci, Jm, Covey, Ds, Zaharko, Kw, Kohn
Publikováno v: Europe PubMed Central
The effects of 5-aza-2'-deoxycytidine on DNA in mouse L1210 leukemia cells were investigated using the alkaline elution technique. By comparing the DNA elution rate at pH 12.1 and 12.6, it was found that the drug produced DNA alkali-labile lesions. A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::32eacb30fa5b50abb89dd271532506ea
https://pubmed.ncbi.nlm.nih.gov/2408746
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4
Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells
Autor: Bae I, Fan S, Bhatia K, Kw, Kohn, Albert Fornace, Connor Pm, O.
Publikováno v: Europe PubMed Central
We investigated temporal relationships between ionizing radiation-induced G1 arrest and induction of the p53-regulated genes GADD45, CIP1/WAF1, and MDM2 in a series of Burkitt's lymphoma and lymphoblastoid cell lines that differed in p53 gene status.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::baac763cb4c96d23741089963ef45f05
http://europepmc.org/abstract/med/7757991
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5
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
Autor: Fan S, Ws, El-Deiry, Bae I, Freeman J, Jondle D, Bhatia K, Albert Fornace, Magrath I, Kw, Kohn, Connor Pm, O.
Publikováno v: Europe PubMed Central
The present study assessed the role of the p53 tumor suppressor gene in cell cycle arrest and apoptosis following treatment of Burkitt's lymphoma and lymphoblastoid cell lines with gamma-rays, etoposide, nitrogen mustard, and cisplatin. Cell cycle ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8ef302f76a33691c064f2bf0f9d115b0
http://europepmc.org/abstract/med/7954409
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7
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
Autor: Connor Pm, O., Jackman J, Bae I, Tg, Myers, Fan S, Mutoh M, Da, Scudiero, Monks A, Ea, Sausville, Jn, Weinstein, Friend S, Albert Fornace, Kw, Kohn
Publikováno v: Europe PubMed Central
In the present study, we report the characterization of the p53 tumor suppressor pathway in the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as correlations between the integrity of this pathway and the growth-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9d05acdec2eafc71f99e33d83cae8955
http://europepmc.org/abstract/med/9331090
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8
Differences in DNA damage produced by incorporation of 5-aza-2'-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells
Autor: Jm, Covey, Maurizio D'Incalci, Ej, Tilchen, Ds, Zaharko, Kw, Kohn
Publikováno v: Europe PubMed Central
The effects of 5-aza-2'-deoxycytidine (aza-dCyd) and 5,6-dihydro-5-azacytidine (H2-aza-Cyd) on the integrity of DNA from several mammalian cell lines were compared using the alkaline elution technique. While both compounds have been shown to inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9eaaf420dc9bc2b22572c68f1a3d16cf
http://europepmc.org/abstract/med/2428479
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9
Akademický článek
SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures.
Autor: Tlemsani C; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Pongor L; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Elloumi F; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Girard L; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX 75390, USA., Huffman KE; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX 75390, USA., Roper N; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Varma S; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Luna A; cBio Center, Division of Biostatistics, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Rajapakse VN; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Sebastian R; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Kohn KW; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Krushkal J; Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, 9609 Medical Center Drive, Rockville, MD 20850, USA., Aladjem MI; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Teicher BA; Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, 9609 Medical Center Drive, Rockville, MD 20850, USA., Meltzer PS; Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Reinhold WC; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Minna JD; Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX 75390, USA., Thomas A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Pommier Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: pommier@nih.gov.
Publikováno v: Cell reports [Cell Rep] 2020 Oct 20; Vol. 33 (3), pp. 108296.
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10
Akademický článek
CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines.
Autor: Rajapakse VN; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: vinodh.rajapakse@nih.gov., Luna A; cBio Center, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA. Electronic address: augustin_luna@hms.harvard.edu., Yamade M; First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan., Loman L; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Varma S; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Sunshine M; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; General Dynamics Information Technology Inc., 3211 Jermantown Road, Fairfax, VA 22030, USA., Iorio F; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Sousa FG; Centro De Estudos Em Células Tronco, Terapia Celular E Genética Toxicológica, Programa De Pós-Graduação Em Farmácia, Universidade Federal De Mato Grosso Do Sul, Campo Grande, MS 79070-900, Brazil., Elloumi F; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; General Dynamics Information Technology Inc., 3211 Jermantown Road, Fairfax, VA 22030, USA., Aladjem MI; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Thomas A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Sander C; cBio Center, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA., Kohn KW; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Benes CH; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA., Garnett M; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Reinhold WC; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Pommier Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: pommier@nih.gov.
Publikováno v: IScience [iScience] 2018 Dec 21; Vol. 10, pp. 247-264. Date of Electronic Publication: 2018 Dec 12.
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