Elevated MARK2-Dependent Phosphorylation of Tau in Alzheimer's Disease.

Autor: Gu GJ, Wu D, Lund H, Sunnemark D, Kvist AJ, Milner R, Eckersley S, Nilsson LN, Agerman K, Landegren U, Kamali-Moghaddam M

Publikováno v: Journal of Alzheimer's Disease; 2013, Vol. 33 Issue 1, p699-713, 15p

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles.

Autor: Yanez Arteta M; Pharmaceutical Sciences iMed Biotech Unit, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden; mariann.yanezarteta@astrazeneca.com lennart.lindfors@astrazeneca.com., Kjellman T; Pharmaceutical Sciences iMed Biotech Unit, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden., Bartesaghi S; Cardiovascular and Metabolic Diseases iMed Bioscience, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden., Wallin S; Cardiovascular and Metabolic Diseases iMed Bioscience, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden., Wu X; Pharmaceutical Sciences iMed Biotech Unit, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden., Kvist AJ; Discovery Science iMed Bioscience, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden., Dabkowska A; Pharmaceutical Sciences iMed Biotech Unit, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden., Székely N; Outstation at Maier-Leibnitz Zentrum, Jülich Centre for Neutrons Science, 857 47 Garching, Germany., Radulescu A; Outstation at Maier-Leibnitz Zentrum, Jülich Centre for Neutrons Science, 857 47 Garching, Germany., Bergenholtz J; Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96 Gothenburg, Sweden., Lindfors L; Pharmaceutical Sciences iMed Biotech Unit, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden; mariann.yanezarteta@astrazeneca.com lennart.lindfors@astrazeneca.com.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Apr 10; Vol. 115 (15), pp. E3351-E3360. Date of Electronic Publication: 2018 Mar 27.

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.

Autor: De Sousa PA; Centre for Clinical Brain Sciences, Chancellors Building, 49 Little France Crescent, University of Edinburgh, Edinburgh EH16 4SB, UK; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK. Electronic address: paul.desousa@ed.ac.uk., Steeg R; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., Wachter E; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., Bruce K; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., King J; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., Hoeve M; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., Khadun S; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., McConnachie G; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., Holder J; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., Kurtz A; Charité - Universitätsmedizin Berlin, Berlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz, Berlin 13353, Germany., Seltmann S; Charité - Universitätsmedizin Berlin, Berlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz, Berlin 13353, Germany., Dewender J; Charité - Universitätsmedizin Berlin, Berlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz, Berlin 13353, Germany., Reimann S; Charité - Universitätsmedizin Berlin, Berlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz, Berlin 13353, Germany., Stacey G; UK Stem Cell Bank, Division of Advanced Therapies, National Institute for Biological Standards and Control, Medicines and Healthcare Products Regulatory Authority, Blanche Lane, South Mimms, Hertfordshire, ENG 3GQ, UK., O'Shea O; UK Stem Cell Bank, Division of Advanced Therapies, National Institute for Biological Standards and Control, Medicines and Healthcare Products Regulatory Authority, Blanche Lane, South Mimms, Hertfordshire, ENG 3GQ, UK., Chapman C; UK Stem Cell Bank, Division of Advanced Therapies, National Institute for Biological Standards and Control, Medicines and Healthcare Products Regulatory Authority, Blanche Lane, South Mimms, Hertfordshire, ENG 3GQ, UK., Healy L; UK Stem Cell Bank, Division of Advanced Therapies, National Institute for Biological Standards and Control, Medicines and Healthcare Products Regulatory Authority, Blanche Lane, South Mimms, Hertfordshire, ENG 3GQ, UK., Zimmermann H; Fraunhofer Institute for Biomedical Engineering (IBMT), Josef-von-Fraunhofer-Weg 1, 66280 Sulzbach, Germany; Molecular & Cellular Biotechnology/Nanotechnology, Saarland University, Campus, 66123 Saarbrücken, Germany., Bolton B; European Collection of Authenticated Cell Cultures, Public Health England, Porton Down, Salisbury SP4 0JG, UK., Rawat T; European Collection of Authenticated Cell Cultures, Public Health England, Porton Down, Salisbury SP4 0JG, UK., Atkin I; European Collection of Authenticated Cell Cultures, Public Health England, Porton Down, Salisbury SP4 0JG, UK., Veiga A; Barcelona Stem Cell Bank, Centre for Regenerative Medicine in Barcelona, C/Dr. Aiguader 88, 08003 Barcelona, Spain., Kuebler B; Barcelona Stem Cell Bank, Centre for Regenerative Medicine in Barcelona, C/Dr. Aiguader 88, 08003 Barcelona, Spain., Serano BM; Andalusian Public Health Care System, Avda Conocimiento sn, 18100 Armilla, Granada, Spain., Saric T; Centre for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Hescheler J; Centre for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Brüstle O; Institute of Reconstructive Neurobiology, LIFE & BRAIN Centre, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany., Peitz M; Institute of Reconstructive Neurobiology, LIFE & BRAIN Centre, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany., Thiele C; Institute of Reconstructive Neurobiology, LIFE & BRAIN Centre, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany., Geijsen N; Hubrecht Institute for developmental biology and stem cell research, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht University, Department of Clinical Sciences of Companion Animals and UMC Utrecht, 3584CT Utrecht, The Netherlands., Holst B; Bioneer A/S, Kogle Alle 2, DK-2970 Hørsholm, Denmark., Clausen C; Bioneer A/S, Kogle Alle 2, DK-2970 Hørsholm, Denmark., Lako M; Institute for Genetic Medicine, University of Newcastle, Newcastle NE1 3BZ, United Kingdom., Armstrong L; Institute for Genetic Medicine, University of Newcastle, Newcastle NE1 3BZ, United Kingdom., Gupta SK; AstraZeneca, R&D, Innovative Medicines, Discovery Sciences, Reagents and Assay Development, HC3006, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Kvist AJ; AstraZeneca, R&D, Innovative Medicines, Discovery Sciences, Reagents and Assay Development, HC3006, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Hicks R; AstraZeneca, R&D, Innovative Medicines, Discovery Sciences, Reagents and Assay Development, HC3006, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Jonebring A; AstraZeneca, R&D, Innovative Medicines, Discovery Sciences, Reagents and Assay Development, HC3006, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Brolén G; AstraZeneca, R&D, Innovative Medicines, Discovery Sciences, Reagents and Assay Development, HC3006, Pepparedsleden 1, SE-431 83 Mölndal, Sweden., Ebneth A; Janssen Research & Development (A Division of Janssen Pharmaceutica N.V), Neuroscience Therapeutic Area, Turnhoutseweg 30, 2340 Beerse, Belgium., Cabrera-Socorro A; Janssen Research & Development (A Division of Janssen Pharmaceutica N.V), Neuroscience Therapeutic Area, Turnhoutseweg 30, 2340 Beerse, Belgium., Foerch P; UCB Biopharma (since May 2014), Discovery Research, Chemin du Foriest, Braine l'Alleud B-1420, Belgium., Geraerts M; UCB Biopharma (since May 2014), Discovery Research, Chemin du Foriest, Braine l'Alleud B-1420, Belgium., Stummann TC; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Harmon S; University of Edinburgh School of Law, Old College, South Bridge, Edinburgh EH8 9YL, UK., George C; University of Edinburgh School of Law, Old College, South Bridge, Edinburgh EH8 9YL, UK., Streeter I; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Clarke L; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Parkinson H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Harrison PW; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Faulconbridge A; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Cherubin L; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Burdett T; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Trigueros C; Inbiomed, P° Mikeletegi, 81, 20009 San Sebastián, Gipuzkoa, Spain., Patel MJ; Cellular Generation and Phenotyping (CGaP) facility, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinston CB10 1SA, UK., Lucas C; Cellular Generation and Phenotyping (CGaP) facility, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinston CB10 1SA, UK., Hardy B; Douglas Connect, Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland., Predan R; Douglas Connect, Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland., Dokler J; Douglas Connect, Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland., Brajnik M; Douglas Connect, Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland., Keminer O; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany., Pless O; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany., Gribbon P; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany., Claussen C; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany., Ringwald A; ARTTIC, 58A rue du Dessous des Berges, F-75013 Paris, France., Kreisel B; ARTTIC, 58A rue du Dessous des Berges, F-75013 Paris, France., Courtney A; Roslin Cells Ltd(1), Head office, Nine Edinburgh Bioquarter, 9 Little France Rd, Edinburgh EH16 4UX, UK; EBiSC banking facility, Babraham Research Campus, B260 Meditrina, Cambridge CB22 3AT, UK., Allsopp TE; Pfizer Ltd (Neusentis), The Portway Building, Granta Park, Great Abington, Cambridge, CB21 6GS, UK.

Publikováno v: Stem cell research [Stem Cell Res] 2017 Apr; Vol. 20, pp. 105-114. Date of Electronic Publication: 2017 Mar 07.

The Use of Antibodies in Small-Molecule Drug Discovery.

Autor: Marsden CJ; AstraZeneca, Macclesfield, Cheshire, UK catherine.marsden@astrazeneca.com., Eckersley S; AstraZeneca, Macclesfield, Cheshire, UK., Hebditch M; AstraZeneca, Macclesfield, Cheshire, UK., Kvist AJ; AstraZeneca, Macclesfield, Cheshire, UK., Milner R; AstraZeneca, Macclesfield, Cheshire, UK., Mitchell D; AstraZeneca, Macclesfield, Cheshire, UK., Warwicker J; AstraZeneca, Macclesfield, Cheshire, UK., Marley AE; AstraZeneca, Macclesfield, Cheshire, UK.

Publikováno v: Journal of biomolecular screening [J Biomol Screen] 2014 Jul; Vol. 19 (6), pp. 829-38. Date of Electronic Publication: 2014 Apr 02.

The major basement membrane components localize to the chondrocyte pericellular matrix--a cartilage basement membrane equivalent?

Autor: Kvist AJ; Department of Experimental Medical Sciences, Lund University, SE-22184 Lund, Sweden., Nyström A, Hultenby K, Sasaki T, Talts JF, Aspberg A

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2008 Jan; Vol. 27 (1), pp. 22-33. Date of Electronic Publication: 2007 Aug 06.