Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kvido Strisovsky"'
Autor:
Abdulbasit Amin, Marina Badenes, Johanna Tüshaus, Érika de Carvalho, Emma Burbridge, Pedro Faísca, Květa Trávníčková, André Barros, Stefania Carobbio, Pedro M. Domingos, Antonio Vidal-Puig, Luís F. Moita, Sarah Maguire, Kvido Stříšovský, Francisco J. Ortega, José Manuel Fernández-Real, Stefan F. Lichtenthaler, Colin Adrain
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101731- (2023)
Objective: The metalloprotease ADAM17 (also called TACE) plays fundamental roles in homeostasis by shedding key signaling molecules from the cell surface. Although its importance for the immune system and epithelial tissues is well-documented, little
Externí odkaz:
https://doaj.org/article/05555155e4744951844c5a7be30e9720
Autor:
Nicholas Johnson, Jana Březinová, Elaine Stephens, Emma Burbridge, Matthew Freeman, Colin Adrain, Kvido Strisovsky
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Rhomboids are intramembrane serine proteases conserved in all kingdoms of life. They regulate epidermal growth factor receptor signalling in Drosophila by releasing signalling ligands from their transmembrane tethers. Their functions in mamm
Externí odkaz:
https://doaj.org/article/9555eb638ea14fcea45029ed279952e0
Autor:
Ioanna Oikonomidi, Emma Burbridge, Miguel Cavadas, Graeme Sullivan, Blanka Collis, Heike Naegele, Danielle Clancy, Jana Brezinova, Tianyi Hu, Andrea Bileck, Christopher Gerner, Alfonso Bolado, Alex von Kriegsheim, Seamus J Martin, Florian Steinberg, Kvido Strisovsky, Colin Adrain
Publikováno v:
eLife, Vol 7 (2018)
The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves TNF from its transmembrane
Externí odkaz:
https://doaj.org/article/dd72ba467b7f4c28b545afaea75874eb
Autor:
Marius K. Lemberg, Kvido Strisovsky
Publikováno v:
Molecular Cell. 81:2507-2519
Protein homeostasis mechanisms are fundamentally important to match cellular needs and to counteract stress conditions. A fundamental challenge is to understand how defective proteins are recognized and extracted from cellular organelles to be degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105e611711788f327f63e9708d16d01e
https://doi.org/10.1016/j.molcel.2021.05.004
https://doi.org/10.1016/j.molcel.2021.05.004
Autor:
John C. Christianson, Jakubec D, Vieira Lc, Kvido Strisovsky, Catarina J. Gaspar, Pedro Domingos, Adrain C
SUMMARYInsertion of hydrophobic transmembrane domains (TMDs) into the endoplasmic reticulum (ER) lipid bilayer is an essential step during eukaryotic membrane protein biogenesis. The ER membrane complex (EMC) functions as an insertase for TMDs of low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c855edc2f71218b969ac69639699f73
https://doi.org/10.1101/2021.02.01.429115
https://doi.org/10.1101/2021.02.01.429115
Autor:
Miranda Rogers, Kvido Strisovsky, Guangyu Liu, Rachel M. Exley, Stephen E. Beaton, Christoph M. Tang, Matthew Freeman, Fraser A. Armstrong, Adam G. Grieve, Rhiannon M. Evans
Publikováno v:
The EMBO Journal
Although multiprotein membrane complexes play crucial roles in bacterial physiology and virulence, the mechanisms governing their quality control remain incompletely understood. In particular, it is not known how unincorporated, orphan components of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a29b3681c55d2968d3e256d7700b694
https://doi.org/10.15252/embj.2019102922
https://doi.org/10.15252/embj.2019102922
Autor:
Kvido Strisovsky, Nicholas Johnson, Johannes Breuning, Adam G. Grieve, Yi Chun Yeh, Marion H. Brown, Matthew Freeman, Anant B. Parekh, Lucrezia Zarcone
SummaryCalcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell mediated immunity. Through a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e220d9305910a3206a5147bdf079546
https://doi.org/10.1101/2020.04.04.025262
https://doi.org/10.1101/2020.04.04.025262
Autor:
Jan Dohnálek, Nicholas Johnson, Kvido Strisovsky, Jan Škerle, Jana Humpolíčková, David Jakubec, Edita Poláchová, Anna Suchánková, Petra Rampírová, Monika Fliegl
Publikováno v:
Biophys J
Many membrane proteins are thought to function as dimers or higher oligomers, but measuring membrane protein oligomerization in lipid membranes is particularly challenging. Forster resonance energy transfer (FRET) and fluorescence cross-correlation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579783605fb408b3b988bd7b3c1837aa
https://europepmc.org/articles/PMC7175701/
https://europepmc.org/articles/PMC7175701/
Publikováno v:
Cell Chem Biol
Rhomboid intramembrane proteases regulate pathophysiological processes, but their targeting in a disease context has never been achieved. We decoded the atypical substrate specificity of malaria rhomboid PfROM4, but found, unexpectedly, that it resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fdd04ec8d3a9b19b28726937eecc11
https://pubmed.ncbi.nlm.nih.gov/32888502
https://pubmed.ncbi.nlm.nih.gov/32888502
Autor:
Rozálie Hexnerová, Mathieu Baudet, Thierry Doan, Jordan Delisle, Anne Galinier, Baptiste Cordier, Jakub Began, Vaclav Veverka, Kvido Strisovsky, Milan Kožíšek, Petra Rampírová, Yohann Couté, Jana Březinová, Pavel Srb
Publikováno v:
EMBO Journal
EMBO Journal, 2020, ⟨10.15252/embj.2019102935⟩
EMBO Journal, EMBO Press, 2020, ⟨10.15252/embj.2019102935⟩
The EMBO Journal
EMBO Journal, 2020, ⟨10.15252/embj.2019102935⟩
EMBO Journal, EMBO Press, 2020, ⟨10.15252/embj.2019102935⟩
The EMBO Journal
Magnesium homeostasis is essential for life and depends on magnesium transporters, whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom, but their functions are largely elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf440d8169298428647796d6463e45e
https://hal.science/hal-02439524/file/Began_et_al-2020-The_EMBO_Journal.pdf
https://hal.science/hal-02439524/file/Began_et_al-2020-The_EMBO_Journal.pdf