Separable Cell Cycle Arrest and Immune Response Elicited through Pharmacological CDK4/6 and MEK Inhibition in RASmut Disease Models.

Autor: Wu J; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Wang J; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., O'Connor TN; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Tzetzo SL; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Gurova KV; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Knudsen ES; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Witkiewicz AK; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.; Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Dec 03; Vol. 23 (12), pp. 1801-1814.

Enhancing Anti-PD-1 Immunotherapy by Targeting MDSCs via Hepatic Arterial Infusion in Breast Cancer Liver Metastases.

Autor: Kim M; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Powers CA; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Fisher DT; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Ku AW; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Neznanov N; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Safina AF; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Wang J; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Gautam A; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Balachandran S; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Krishnamurthy A; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Gurova KV; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Evans SS; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Gudkov AV; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Skitzki JJ; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.

Publikováno v: Cancers [Cancers (Basel)] 2024 Nov 03; Vol. 16 (21). Date of Electronic Publication: 2024 Nov 03.

The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression.

Autor: Xiao L; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia., Karsa M; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia., Ronca E; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia., Bongers A; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia., Kosciolek A; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia., El-Ayoubi A; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia., Revalde JL; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; Australian Cancer Research Foundation (ACRF) Drug Discovery Centre for Childhood Cancer, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia., Seneviratne JA; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia., Cheung BB; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia., Cheung LC; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia.; Curtin Medical School, Curtin University, Perth, WA, Australia.; Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia., Kotecha RS; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia.; Curtin Medical School, Curtin University, Perth, WA, Australia.; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, WA, Australia.; Division of Paediatrics, School of Medicine, University of Western Australia, Perth, WA, Australia., Newbold A; Gene Regulation Laboratory, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia., Bjelosevic S; Gene Regulation Laboratory, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia., Arndt GM; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia.; Australian Cancer Research Foundation (ACRF) Drug Discovery Centre for Childhood Cancer, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia., Lock RB; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia., Johnstone RW; Gene Regulation Laboratory, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia., Gudkov AV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States., Gurova KV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, United States., Haber M; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia., Norris MD; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia.; University of New South Wales Centre for Childhood Cancer Research, Sydney, NSW, Australia., Henderson MJ; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia., Somers K; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia.

Publikováno v: Frontiers in oncology [Front Oncol] 2022 May 23; Vol. 12, pp. 863329. Date of Electronic Publication: 2022 May 23 (Print Publication: 2022).

Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma.

Autor: Xiao L; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Somers K; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Murray J; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Pandher R; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Karsa M; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Ronca E; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Bongers A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Terry R; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Ehteda A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Gamble LD; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Issaeva N; Department of Otolaryngology/Head and Neck Surgery, Department of Pathology and Lab Medicine, Lineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, North Carolina., Leonova KI; Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York., O'Connor A; Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia., Mayoh C; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Venkat P; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Quek H; Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Brand J; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Kusuma FK; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Pettitt JA; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Mosmann E; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Kearns A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Eden G; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Alfred S; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Allan S; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Zhai L; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Kamili A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Gifford AJ; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Carter DR; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.; School of Biomedical Engineering, University of Technology Sydney, Australia., Henderson MJ; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Fletcher JI; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia., Marshall G; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia., Johnstone RW; Immune Defence Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Cesare AJ; Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia., Ziegler DS; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia., Gudkov AV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York., Gurova KV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York., Norris MD; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia. mhaber@ccia.unsw.edu.au mnorris@ccia.unsw.edu.au.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.; University of New South Wales Centre for Childhood Cancer Research, Sydney, Australia., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia. mhaber@ccia.unsw.edu.au mnorris@ccia.unsw.edu.au.; School of Women's and Children's Health, University of New South Wales Sydney, Randwick, New South Wales, Australia.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Aug 01; Vol. 27 (15), pp. 4338-4352. Date of Electronic Publication: 2021 May 16.

A Translational Hepatic Artery Infusion (HAI) Model for Hepatocellular Carcinoma in Woodchucks.

Autor: Kim M; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Powers CA; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Curtin LI; Laboratory Animal Shared Resources, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Fisher DT; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Sexton S; Laboratory Animal Shared Resources, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Gurova KV; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Skitzki JJ; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Iyer RV; Department of Internal Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York. Electronic address: Renuka.Iyer@RoswellPark.org.

Publikováno v: The Journal of surgical research [J Surg Res] 2020 Jul; Vol. 251, pp. 126-136. Date of Electronic Publication: 2020 Mar 03.