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Rapid BRAF mutation detection in melanoma patients by immunohistochemistry

Autor: Fülöp, László, Götzer, Katalin, Csernák, Erzsébet, Kuznyecov, Danyil Szergejevics, Tóth, Erika

The V600E mutation is the most common (~90%) activating mutation of the BRAF gene. BRAF mutations have been frequently investigated in melanoma, colorectal cancer and papillary thyroid carcinoma. The importance of the detection of BRAF mutations has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4a47895ab769689a0848dc6b0fbe67c

An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.

Autor: Fernández Moro C; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, 14186, Sweden.; Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, 14186, Stockholm, Sweden., Geyer N; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden., Harrizi S; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden., Hamidi Y; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden., Söderqvist S; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden., Kuznyecov D; Department of Clinical Genetics, Pathology and Molecular Diagnostics, Medicinsk Service, Skåne University Hospital, 22185, Lund, Sweden., Tidholm Qvist E; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, 14186, Sweden., Salmonson Schaad M; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden., Hermann L; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden., Lindberg A; Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden., Heuchel RL; Pancreatic Cancer Research Laboratory, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 14183, Hudinge, Sweden., Martín-Bernabé A; Department of Oncology-Pathology, Karolinska Institutet, 17176, Solna, Sweden., Dhanjal S; CRISPR Functional Genomics, SciLifeLab and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17165, Solna, Sweden., Navis AC; CRISPR Functional Genomics, SciLifeLab and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17165, Solna, Sweden., Villard C; Department of Medicine Huddinge, Karolinska Institutet, 14183, Huddinge, Sweden., Del Valle AC; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden., Bozóky L; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden., Sparrelid E; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, Karolinska University Hospital, 14152, Stockholm, Sweden., Dirix L; Translational Cancer Research Unit (GZA Hospitals and University of Antwerp), Antwerp, Belgium., Strell C; Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden.; Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, 5020, Bergen, Norway., Östman A; Department of Oncology-Pathology, Karolinska Institutet, 17176, Solna, Sweden., Schmierer B; CRISPR Functional Genomics, SciLifeLab and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17165, Solna, Sweden., Vermeulen PB; Translational Cancer Research Unit (GZA Hospitals and University of Antwerp), Antwerp, Belgium., Engstrand J; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institutet, Karolinska University Hospital, 14152, Stockholm, Sweden., Bozóky B; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, 14186, Sweden., Gerling M; Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden. marco.gerling@ki.se.; Theme Cancer, Karolinska University Hospital, 17 176, Solna, Sweden. marco.gerling@ki.se.

Publikováno v: Nature communications [Nat Commun] 2023 Aug 18; Vol. 14 (1), pp. 5024. Date of Electronic Publication: 2023 Aug 18.