Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Kuzhuvelil B. Harikumar"'
Autor:
Krishnaprasad Baby, Swastika Maity, Chetan Hasmukh Mehta, Usha Y. Nayak, Gautham G. Shenoy, Karkala Sreedhara Ranganath Pai, Kuzhuvelil B. Harikumar, Yogendra Nayak
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-25 (2023)
Abstract Non-small cell lung carcinomas (NSCLC) are the predominant form of lung malignancy and the reason for the highest number of cancer-related deaths. Widespread deregulation of Akt, a serine/threonine kinase, has been reported in NSCLC. Alloste
Externí odkaz:
https://doaj.org/article/bbd955a7e0b141d0b83136abbc8208ea
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/99a6aeafaa6942ebbf394e811fcfd919
Publikováno v:
Molecular Cancer, Vol 18, Iss 1, Pp 1-13 (2019)
Abstract Among all the deadly cancers, pancreatic cancer ranks seventh in mortality. The absence of any grave symptoms coupled with the unavailability of early prognostic and diagnostic markers make the disease incurable in most of the cases. This le
Externí odkaz:
https://doaj.org/article/367dfbb2165d46199b092ffe68123560
Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma
Autor:
Mundanattu Swetha, Chenicheri K. Keerthana, Tennyson P. Rayginia, Lekshmi R. Nath, Nair Hariprasad Haritha, Anwar Shabna, Kalishwaralal Kalimuthu, Arun K. Thangarasu, Sreekumar U. Aiswarya, Somaraj Jannet, Sreekumar Pillai, Kuzhuvelil B. Harikumar, Sankar Sundaram, Nikhil Ponnoor Anto, Dee H. Wu, Ravi S. Lankalapalli, Rheal Towner, Noah Isakov, Sathyaseelan S. Deepa, Ruby John Anto
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 636 (2022)
We previously reported the remarkable potency of uttroside B (Utt-B), saponin-isolated and characterized in our lab from Solanum nigrum Linn, against HCC. Recently, the U.S. FDA approved Utt-B as an ‘orphan drug’ against HCC. The current study va
Externí odkaz:
https://doaj.org/article/b186c71c587e4df097a4a4b437a83fd0
Autor:
Aditi Majumder, Khaja Moheiddin Syed, Ananda Mukherjee, Manendra Babu Lankadasari, Juberiya Mohammed Azeez, Sreeharshan Sreeja, Kuzhuvelil B. Harikumar, Madhavan Radhakrishna Pillai, Debasree Dutta
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-9 (2018)
Abstract DNA damage-specific histone chaperone Aprataxin PNK-like factor (APLF) regulates mesenchymal-to-epithelial transition (MET) during cellular reprogramming. We investigated the role of APLF in epithelial-to-mesenchymal transition (EMT) linked
Externí odkaz:
https://doaj.org/article/fd93f10aed1a43358997ec3c3d5cfed3
Autor:
Shirley James, Jayasekharan S. Aparna, Anu Babu, Aswathy Mary Paul, Manendra Babu Lankadasari, Subha R. Athira, Sreesha S. Kumar, Yadu Vijayan, Narayanan N. Namitha, Sabira Mohammed, Girijadevi Reshmi, Kuzhuvelil B. Harikumar
Publikováno v:
Biomolecules, Vol 11, Iss 5, p 661 (2021)
Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems.
Externí odkaz:
https://doaj.org/article/4288c49aab614b2792fddb491ee82fbb
Autor:
Sushovan Guha, Christopher R. Ireson, Enrique Rozengurt, Bharat B. Aggarwal, Sunil Krishnan, Juri Gelovani, James Sinnett-Smith, Yoichi Matsuo, Parmeswaran Diagaradjane, Dipen Maru, Muddasar Farooq, Alexandra Boakes, Caroline Foxton, Azadeh Bagherzadeh, Mark Charles, Tony Raynham, Rachel Sutherland, Stephen Jamieson, Lloyd Kelland, Bokyung Sung, Amit Deorukhkar, Zhimin Tong, Nobuo Ochi, Ajaikumar B. Kunnumakkara, Kuzhuvelil B. Harikumar
Protein kinase D (PKD) family members are increasingly implicated in multiple normal and abnormal biological functions, including signaling pathways that promote mitogenesis in pancreatic cancer. However, nothing is known about the effects of targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab32f00e1cc289882edd000632bf0373
https://doi.org/10.1158/1535-7163.c.6531675.v1
https://doi.org/10.1158/1535-7163.c.6531675.v1
Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
Autor:
Joyce Slingerland, Claes Wahlestedt, Diana Azzam, Zhiqun Zhou, Derek Van Booven, Gray Pearson, Apsra Nasir, Andrew J. Ewald, Matthew Dunworth, Kuzhuvelil B. Harikumar, Seyedeh Fatemeh Razavipour, Hetakshi Kurani
Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b2c2a99ceb52ac7539304e737c3627
https://doi.org/10.1158/1078-0432.22482617
https://doi.org/10.1158/1078-0432.22482617
Autor:
Joyce Slingerland, Claes Wahlestedt, Diana Azzam, Zhiqun Zhou, Derek Van Booven, Gray Pearson, Apsra Nasir, Andrew J. Ewald, Matthew Dunworth, Kuzhuvelil B. Harikumar, Seyedeh Fatemeh Razavipour, Hetakshi Kurani
Supplementary Data from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fac0b031926614dedc58a978f1c7414
https://doi.org/10.1158/1078-0432.22482626
https://doi.org/10.1158/1078-0432.22482626
Autor:
Sushovan Guha, Christopher R. Ireson, Enrique Rozengurt, Bharat B. Aggarwal, Sunil Krishnan, Juri Gelovani, James Sinnett-Smith, Yoichi Matsuo, Parmeswaran Diagaradjane, Dipen Maru, Muddasar Farooq, Alexandra Boakes, Caroline Foxton, Azadeh Bagherzadeh, Mark Charles, Tony Raynham, Rachel Sutherland, Stephen Jamieson, Lloyd Kelland, Bokyung Sung, Amit Deorukhkar, Zhimin Tong, Nobuo Ochi, Ajaikumar B. Kunnumakkara, Kuzhuvelil B. Harikumar
Supplementary Data from A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146fb75ff91e4ab866310a4198e944e7
https://doi.org/10.1158/1535-7163.22484955
https://doi.org/10.1158/1535-7163.22484955