Zobrazeno 1 - 10 of 263 pro vyhledávání: '"Kuvelkar, R."'
1
Akademický článek
Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods.
Autor: Gathiaka S; Computational & Structural Chemistry, Merck & Co., Inc., Boston, MA 02115, USA. Electronic address: symon.gathiaka@gmail.com., Palte RL; Computational & Structural Chemistry, Merck & Co., Inc., Boston, MA 02115, USA., So SS; Computational & Structural Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Chai X; Quantitative Biosciences, Merck & Co., Inc., Boston, NJ 02115, USA., Richard Miller J; Quantitative Biosciences, Merck & Co., Inc., Boston, MA 02115, USA., Kuvelkar R; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Wen X; Computational & Structural Chemistry, Merck & Co., Inc., Boston, MA 02115, USA., Cifelli S; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Kreamer A; Screening, Target and Compound Profiling, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Liaw A; Biometrics Research, Merck & Co., Inc., Rahway, 90 E Scott Ave, Rahway, NJ 07065, USA., McLaren DG; Computational & Structural Chemistry, Merck & Co., Inc., Boston, MA 02115, USA., Fischer C; Discovery Chemistry, Merck & Co., Inc., Boston, MA 02115, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Mar 15; Vol. 84, pp. 129193. Date of Electronic Publication: 2023 Feb 21.
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2
Akademický článek
High-Throughput Bioassays using "Dip-and-Go" Multiplexed Electrospray Mass Spectrometry.
Autor: Wei Z; Aston Labs, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47906-1393, USA., Xie Z; Aston Labs, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47906-1393, USA., Kuvelkar R; Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Shah V; Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Bateman K; Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., McLaren DG; Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA., Cooks RG; Aston Labs, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47906-1393, USA.
Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Dec 02; Vol. 58 (49), pp. 17594-17598. Date of Electronic Publication: 2019 Oct 23.
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3
Akademický článek
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.
Autor: Mandal M, Mitra K, Grotz D, Lin X, Palamanda J, Kumari P, Buevich A, Caldwell JP, Chen X, Cox K, Favreau L, Hyde L, Kennedy ME, Kuvelkar R, Liu X, Mazzola RD, Parker E, Rindgen D, Sherer E, Wang H, Zhu Z, Stamford AW, Cumming JN
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Dec 13; Vol. 61 (23), pp. 10700-10708. Date of Electronic Publication: 2018 Nov 15.
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6
Akademický článek
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors
Autor: Iserloh, U., Wu, Y., Cumming, J.N., Pan, J., Wang, L.Y., Stamford, A.W., Kennedy, M.E., Kuvelkar, R., Chen, X., Parker, E.M., Strickland, C., Voigt, J.
Publikováno v: In Bioorganic & Medicinal Chemistry Letters 2008 18(1):414-417
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7
Akademický článek
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
Autor: Scott JD; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., DeMong DE; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Greshock TJ; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Basu K; Merck & Co., Inc. , 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Dai X; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Harris J; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Hruza A; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Li SW; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Lin SI; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Liu H; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Macala MK; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Hu Z; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Mei H; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Zhang H; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Walsh P; Merck & Co., Inc. , 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Poirier M; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Shi ZC; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Xiao L; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Agnihotri G; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Baptista MA; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Columbus J; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Fell MJ; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hyde LA; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Kuvelkar R; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Lin Y; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Mirescu C; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Morrow JA; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Yin Z; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Zhang X; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Zhou X; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Chang RK; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Embrey MW; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Sanders JM; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Tiscia HE; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Drolet RE; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Kern JT; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Sur SM; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Renger JJ; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Bilodeau MT; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Kennedy ME; Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Parker EM; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Stamford AW; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Nargund R; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., McCauley JA; Merck & Co., Inc. , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Miller MW; Merck & Co., Inc. , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Apr 13; Vol. 60 (7), pp. 2983-2992. Date of Electronic Publication: 2017 Mar 16.
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8
Akademický článek
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9
Akademický článek
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10
Akademický článek
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
Autor: Scott JD, Li SW, Brunskill AP, Chen X, Cox K, Cumming JN, Forman M, Gilbert EJ, Hodgson RA, Hyde LA, Jiang Q; Albany Molecular Research Inc. , 26 Corporate Circle, Albany, New York 12203, United States., Iserloh U, Kazakevich I, Kuvelkar R, Mei H, Meredith J, Misiaszek J, Orth P, Rossiter LM; Albany Molecular Research Inc. , 26 Corporate Circle, Albany, New York 12203, United States., Slater M; Albany Molecular Research Inc. , 26 Corporate Circle, Albany, New York 12203, United States., Stone J, Strickland CO, Voigt JH, Wang G, Wang H, Wu Y, Greenlee WJ, Parker EM, Kennedy ME, Stamford AW
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Dec 08; Vol. 59 (23), pp. 10435-10450. Date of Electronic Publication: 2016 Nov 18.
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