Inhibition of the poly-ADP-ribosylation activity of tankyrases : role in obesity, diabetes and kidney injury

Autor: Kuusela, Sara

Background: Type 2 diabetes is characterized by hyperglycemia and insulin resistance, and apart from genetic susceptibility to the disease, its major risk factor is obesity. Diabetic kidney disease is a common complication of diabetes and the leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1593::b4c59069756c66294ec544cfb3c35a4d
http://hdl.handle.net/10138/329829

Cyclin-dependent kinase 2 protects podocytes from apoptosis

Autor: Saurus, Pauliina, Kuusela, Sara, Dumont, Vincent, Lehtonen, Eero, Fogarty, Christopher L., Lassenius, Mariann I., Forsblom, Carol, Lehto, Markku, Saleem, Moin A., Groop, Per-Henrik, Lehtonen, Sanna

Publikováno v: Scientific Reports
Saurus, P, Kuusela, S, Dumont, V, Lehtonen, E, Fogarty, C L, Lassenius, M I, Forsblom, C, Lehto, M, Saleem, M A, Groop, P-H & Lehtonen, S 2016, ' Cyclin-dependent kinase 2 protects podocytes from apoptosis ', Scientific Reports, vol. 6, 21664 . https://doi.org/10.1038/srep21664

Loss of podocytes is an early feature of diabetic nephropathy (DN) and predicts its progression. We found that treatment of podocytes with sera from normoalbuminuric type 1 diabetes patients with high lipopolysaccharide (LPS) activity, known to predi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698eff401b791265a90d0077a92cbdec

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