Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors

Autor: Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Havunen, Riikka, Santos, Joao M., Kutvonen, Emma, Clubb, James H.A., Siurala, Mikko, Heiniö, Camilla, Zafar, Sadia, Koivula, Teija, Lumen, Dave, Vaha, Marjo, Garcia-Horsman, Arturo, Airaksinen, Anu J., Sorsa, Suvi, Anttila, Marjukka, Hukkanen, Veijo, Kanerva, Anna, Hemminki, Akseli

Publikováno v: In Molecular Therapy - Oncolytics 26 June 2020 17:47-60

VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro .

Autor: Laine LJ; VTT Health, VTT Technical Research Centre of Finland Ltd., Otaniemi, Finland.; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku 20520, Finland.; These authors contributed equally to this work., Mäki-Jouppila JHE; VTT Health, VTT Technical Research Centre of Finland Ltd., Otaniemi, Finland.; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku 20520, Finland.; Drug Research Doctoral Programme, University of Turku, Finland.; Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.; These authors contributed equally to this work., Kutvonen E; VTT Health, VTT Technical Research Centre of Finland Ltd., Otaniemi, Finland.; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku 20520, Finland., Tiikkainen P; VTT Health, VTT Technical Research Centre of Finland Ltd., Otaniemi, Finland., Nyholm TKM; Department of Biosciences, Åbo Akademi University, Turku, Finland., Tien JF; Department of Biochemistry, University of Washington, Seattle, WA, USA., Umbreit NT; Department of Biochemistry, University of Washington, Seattle, WA, USA., Härmä V; VTT Health, VTT Technical Research Centre of Finland Ltd., Otaniemi, Finland., Kallio L; VTT Health, VTT Technical Research Centre of Finland Ltd., Otaniemi, Finland., Davis TN; Department of Biochemistry, University of Washington, Seattle, WA, USA., Asbury CL; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Poso A; School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Gorbsky GJ; Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Kallio MJ; VTT Health, VTT Technical Research Centre of Finland Ltd., Otaniemi, Finland.; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku 20520, Finland.

Publikováno v: Oncoscience [Oncoscience] 2021 Dec 10; Vol. 8, pp. 134-153. Date of Electronic Publication: 2021 Dec 10 (Print Publication: 2021).