Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kuttikkatte, SB"'
Autor:
Dendrou, CA, Cortes, A, Shipman, L, Evans, HG, Attfield, KE, Jostins, L, Barber, T, Kaur, G, Kuttikkatte, SB, Leach, OA, Desel, C, Faergeman, SL, Cheeseman, J, Neville, MJ, Sawcer, S, Compston, A, Johnson, AR, Everett, C, Bell, JI, Karpe, F, Ultsch, M, Eigenbrot, C, McVean, G, Fugger, L
Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a11182731ee452ca491b63d96777e4
https://www.repository.cam.ac.uk/handle/1810/262725
https://www.repository.cam.ac.uk/handle/1810/262725
Autor:
Kaur G; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lee J; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Riesenfeld SJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.; Department of Medicine, University of Chicago, Chicago, IL, USA., Hofree M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aggelakopoulou M; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Subramanian A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kuttikkatte SB; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Attfield KE; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Desel CAE; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; University Department of Neurology, University Hospital Magdeburg, Magdeburg, Germany., Davies JL; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Evans HG; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Avraham-Davidi I; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen LT; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dionne DA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Neumann AE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jensen LT; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark., Barber TR; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Soilleux E; Department of Pathology, Tennis Court Rd, University of Cambridge, Cambridge, England., Carrington M; Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., McVean G; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, 1 DNA Way, South San Francisco, CA, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aregev@broadinstitute.org.; Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA. aregev@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aregev@broadinstitute.org.; Genentech, 1 DNA Way, South San Francisco, CA, USA. aregev@broadinstitute.org., Fugger L; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. lars.fugger@ndcn.ox.ac.uk.; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. lars.fugger@ndcn.ox.ac.uk.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. lars.fugger@ndcn.ox.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2022 Jul 29; Vol. 13 (1), pp. 4398. Date of Electronic Publication: 2022 Jul 29.
Autor:
Faergeman SL; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, DK-8200, Denmark., Evans H; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK., Attfield KE; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK., Desel C; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK., Kuttikkatte SB; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK., Sommerlund M; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, DK-8200, Denmark., Jensen LT; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, DK-8200, Denmark., Frokiaer J; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, DK-8200, Denmark., Friese MA; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany., Matthews PM; Division of Brain Sciences, Department of Medicine, UK Dementia Research Institute, Imperial College London, London, SW7 2AZ, UK., Luchtenborg C; Heidelberg University Biochemistry Center (BZH), Heidelberg, D-69120, Germany., Brügger B; Heidelberg University Biochemistry Center (BZH), Heidelberg, D-69120, Germany., Oturai AB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Copenhagen, 2100, Denmark., Dendrou CA; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Fugger L; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK. lars.fugger@imm.ox.ac.uk.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK. lars.fugger@imm.ox.ac.uk.
Publikováno v:
Cell death & disease [Cell Death Dis] 2020 May 01; Vol. 11 (5), pp. 303. Date of Electronic Publication: 2020 May 01.
Autor:
Kaur G; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Gras S; Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia., Mobbs JI; Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia., Vivian JP; Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia., Cortes A; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Barber T; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Kuttikkatte SB; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Jensen LT; Department of Clinical Medicine, Aarhus University Hospital, 8200N Aarhus, Denmark., Attfield KE; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Dendrou CA; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Carrington M; Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.; The Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts 02139, USA., McVean G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK., Purcell AW; Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia., Rossjohn J; Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK., Fugger L; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Department of Clinical Medicine, Aarhus University Hospital, 8200N Aarhus, Denmark.
Publikováno v:
Nature communications [Nat Commun] 2017 Jun 26; Vol. 8, pp. 15924. Date of Electronic Publication: 2017 Jun 26.
Autor:
Dendrou CA; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Cortes A; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Shipman L; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Evans HG; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Attfield KE; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Jostins L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Barber T; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Kaur G; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Kuttikkatte SB; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Leach OA; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Desel C; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Faergeman SL; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark., Cheeseman J; Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LE, UK., Neville MJ; Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LE, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals Trust, Churchill Hospital, Oxford OX3 7LE, UK., Sawcer S; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK., Compston A; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK., Johnson AR; Structural Biology and Biochemical Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Everett C; Structural Biology and Biochemical Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Bell JI; University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7DG, UK., Karpe F; Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LE, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals Trust, Churchill Hospital, Oxford OX3 7LE, UK., Ultsch M; Structural Biology and Biochemical Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Eigenbrot C; Structural Biology and Biochemical Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., McVean G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Fugger L; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK. lars.fugger@imm.ox.ac.uk.; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark.
Publikováno v:
Science translational medicine [Sci Transl Med] 2016 Nov 02; Vol. 8 (363), pp. 363ra149.