Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Kusum K, Kharbanda"'
Autor:
Sundararajan Mahalingam, Ramesh Bellamkonda, Kusum K. Kharbanda, Madan Kumar Arumugam, Vikas Kumar, Carol A. Casey, Lorenzo Leggio, Karuna Rasineni
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116595- (2024)
Fatty liver is the earliest response of the liver to excessive alcohol consumption. Previously we identified that chronic alcohol administration increases levels of stomach-derived hormone, ghrelin, which by reducing circulating insulin levels, ultim
Externí odkaz:
https://doaj.org/article/b9357bba242e491aa09ac86d028401a4
Autor:
Natalia A. Osna, Irina Tikhanovich, Martí Ortega-Ribera, Sebastian Mueller, Chaowen Zheng, Johannes Mueller, Siyuan Li, Sadatsugu Sakane, Raquel Carvalho Gontijo Weber, Hyun Young Kim, Wonseok Lee, Souradipta Ganguly, Yusuke Kimura, Xiao Liu, Debanjan Dhar, Karin Diggle, David A. Brenner, Tatiana Kisseleva, Neha Attal, Iain H. McKillop, Shilpa Chokshi, Ram Mahato, Karuna Rasineni, Gyongyi Szabo, Kusum K. Kharbanda
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 404 (2024)
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Mult
Externí odkaz:
https://doaj.org/article/142e2cdd280940af8c937a0c17615d54
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/09b8319a128248dc8e6a68fd0b06b757
Autor:
Grace Bybee, Youra Moeun, Weimin Wang, Kusum K. Kharbanda, Larisa Y. Poluektova, Srivatsan Kidambi, Natalia A. Osna, Murali Ganesan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHepatitis B virus (HBV) infection develops as an acute or chronic liver disease, which progresses from steatosis, hepatitis, and fibrosis to end-stage liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). An increased stromal
Externí odkaz:
https://doaj.org/article/7dce5104bbc04432b98de9d85196fe16
Autor:
Madan Kumar Arumugam, Thiyagarajan Gopal, Rakhee Rathnam Kalari Kandy, Lokesh Kumar Boopathy, Sathish Kumar Perumal, Murali Ganesan, Karuna Rasineni, Terrence M. Donohue, Natalia A. Osna, Kusum K. Kharbanda
Publikováno v:
Biology, Vol 12, Iss 10, p 1311 (2023)
The liver is a major metabolic organ that performs many essential biological functions such as detoxification and the synthesis of proteins and biochemicals necessary for digestion and growth. Any disruption in normal liver function can lead to the d
Externí odkaz:
https://doaj.org/article/4e7a482ef3c94cdc9ac00212a22e41ef
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/1d357b6d166345ed9fd32d49655bff41
Autor:
Madan Kumar Arumugam, Srinivas Chava, Sathish Kumar Perumal, Matthew C. Paal, Karuna Rasineni, Murali Ganesan, Terrence M. Donohue, Natalia A. Osna, Kusum K. Kharbanda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Binge drinking is the most common form of excessive alcohol use. Repeated episodes of binge drinking cause multiple organ injuries, including liver damage. We previously demonstrated that chronic ethanol administration causes a decline in the intrahe
Externí odkaz:
https://doaj.org/article/eaf8e05e96324900b30d6422b63595e0
Autor:
Madan Kumar Arumugam, Srinivas Chava, Karuna Rasineni, Matthew C. Paal, Terrence M. Donohue, Natalia A. Osna, Kusum K. Kharbanda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract It has been previously shown that chronic ethanol administration-induced increase in adipose tissue lipolysis and reduction in the secretion of protective adipokines collectively contribute to alcohol-associated liver disease (ALD) pathogene
Externí odkaz:
https://doaj.org/article/1360dbbed2824d8b8186be793004b477
Autor:
Moses New-Aaron, Siva Sankar Koganti, Murali Ganesan, Sharma Kanika, Vikas Kumar, Weimin Wang, Edward Makarov, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5346 (2023)
Liver disease is one of the leading comorbidities in HIV infection. The risk of liver fibrosis development is potentiated by alcohol abuse. In our previous studies, we reported that hepatocytes exposed to HIV and acetaldehyde undergo significant apop
Externí odkaz:
https://doaj.org/article/6c285c24e80e4a9199f05390a451df3a
Autor:
Madan Kumar Arumugam, Sathish Kumar Perumal, Karuna Rasineni, Terrence M. Donohue, Natalia A. Osna, Kusum K. Kharbanda
Publikováno v:
Biology, Vol 12, Iss 3, p 462 (2023)
The earliest manifestation of alcohol-associated liver disease is hepatic steatosis, which is characterized by fat accumulation in specialized organelles called lipid droplets (LDs). Our previous studies reported that alcohol consumption elevates the
Externí odkaz:
https://doaj.org/article/8ce0b21f488f4db08ef7649496ba43d6