Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kushal J. Rohilla"'
Autor:
Kushal J. Rohilla, Keith T. Gagnon
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-22 (2017)
Abstract Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome and have important roles in genome evolution and function. However, the expansion of microsatellites is associated with over two dozen neurological disea
Externí odkaz:
https://doaj.org/article/00125664e64345b3be8fe5ee23e53b38
Autor:
Kushal J. Rohilla, Keith T. Gagnon, Adrian A Pater, Maria Barton, Katy N Ovington, Anthony J Henke
Publikováno v:
Hum Genet
Approximately 3% of the human genome is composed of short tandem repeat (STR) DNA sequence known as microsatellites, which can be found in both coding and non-coding regions. When associated with genic regions, expansion of microsatellite repeats bey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948e303aaa2c57f6dcf4f14b00bd039a
https://doi.org/10.1007/s00439-020-02165-z
https://doi.org/10.1007/s00439-020-02165-z
Autor:
Swati Naphade, Keith T. Gagnon, Motahareh Taki, Lisa M. Ellerby, Kushal J. Rohilla, Madison Funneman, Najiyah Benzabeh, Mohtashim H. Shamsi, Maria Barton
Publikováno v:
Anal Bioanal Chem
DNA repeat expansion sequences cause a myriad of neurological diseases when they expand beyond a critical threshold. Previous electrochemical approaches focused on the detection of trinucleotide repeats (CAG, CGG, and GAA) and relied on labeling of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1465b0e3f2dd223239c7c8399a81b7e
https://doi.org/10.1007/s00216-019-02075-8
https://doi.org/10.1007/s00216-019-02075-8
Publikováno v:
Nucleic Acid Therapeutics
Clustered regularly interspaced short palindromic repeat (CRISPR) RNAs and their associated effector (Cas) enzymes are being developed into promising therapeutics to treat disease. However, CRISPR-Cas enzymes might produce unwanted gene editing or da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c273e7c519b9a8094a5c3e12a1b9fc
https://doi.org/10.1089/nat.2018.0758
https://doi.org/10.1089/nat.2018.0758
Autor:
Masad J. Damha, Eman A Ageely, Austin T. Weigle, Annabelle Schofield, Keith T. Gagnon, Daniel O'Reilly, Kushal J. Rohilla, Lauren B DeRossett, Maryam Habibian, Zachary J. Kartje, Elise Malek-Adamian, Christopher L. Barkau
Publikováno v:
Nucleic Acids Research
CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4857e32986527cde2d767f9ee31968f
https://doi.org/10.1093/nar/gky1214
https://doi.org/10.1093/nar/gky1214
Publikováno v:
Biochemistry. 57(21)
DNA substitutions in RNA can probe the importance of A-form structure, 2'-hydroxyl contacts, and conformational constraints within RNA-guided enzymes. Using this approach, we found that Cas9 biochemical activity tolerated significant substitution wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcd0c3657329b316eb8c9238487db1d
https://pubmed.ncbi.nlm.nih.gov/29746102
https://pubmed.ncbi.nlm.nih.gov/29746102
Publikováno v:
ACS chemical biology. 11(9)
The spinach family of RNA aptamers are RNA mimics of green fluorescent protein (GFP) that have previously been designed to address the challenges of imaging RNA inside living cells. However, relatively low levels of free intracellular magnesium limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32939829da41f8a33b34708982da6d2f
https://pubmed.ncbi.nlm.nih.gov/27467146
https://pubmed.ncbi.nlm.nih.gov/27467146