Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kush Dalal"'
Autor:
Kevin J. Tam, Liangliang Liu, Michael Hsing, Kush Dalal, Daksh Thaper, Brian McConeghy, Parvin Yenki, Satyam Bhasin, James W. Peacock, Yuzhuo Wang, Artem Cherkasov, Paul S. Rennie, Martin E. Gleave, Christopher J. Ong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevale
Externí odkaz:
https://doaj.org/article/04472dd65cc24c0c8a00dc7c0f4fd55c
Autor:
Kate Gibson, Peter Bergqvist, Lauren Chong, Davide Tortora, Tim Jacobs, Patrick Farber, Ryan Blackler, Antonios Samiotakis, Harveer Dhupar, Craig Robb, Allison Goodman, Cindy-Lee Crichlow, Melissa Cid, Jessica Fernandes Scortecci, Rodrigo Goya, Eduardo Solano Salgado, Ping Xiang, Ahn Lee, Irene Yu, Gabrielle Conaghan, Nathalie Blamey, Vivian Li, Valentine de Puyraimond, Patrick Rowe, Kush Dalal, Stephanie K Masterman, Tara Fernandez, Raffi Tonikian, Bryan C Barnhart
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/9b88c8a655364590abc1562cccce3c2f
Autor:
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J. Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W. Siegel, Jinbiao Chen, Beverly A. Heinz, Richard E. Higgs, Nicole L. Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A. Garces, Courtney A. Cohen, John M. Dye, Kathleen E. Huie, Catherine V. Badger, Darwyn Kobasa, Jonathan Audet, Joshua J. Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C. Palma, Bharathi Ramamurthy, Robert W. Cross, Thomas W. Geisbert, Vineet Menachery, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S. Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D. Kwong, Nancy J. Sullivan, Barney S. Graham, Tara L. Fernandez, Carl L. Hansen, Ester Falconer, John R. Mascola, Bryan E. Jones, Bryan C. Barnhart
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110812- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of c
Externí odkaz:
https://doaj.org/article/daeff3ff2f814504a3643f35bb419fcf
Autor:
Tunç Morova, Daniel R. McNeill, Nada Lallous, Mehmet Gönen, Kush Dalal, David M. Wilson, Attila Gürsoy, Özlem Keskin, Nathan A. Lack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development. Here, utilising clinical whole genome sequencing data, the authors show that the non-coding AR binding sites on DNA are frequently mutated in prostat
Externí odkaz:
https://doaj.org/article/15a98cfbbcff421a8c1487325afd7722
Autor:
Mariia Radaeva, Huifang Li, Eric LeBlanc, Kush Dalal, Fuqiang Ban, Fabrice Ciesielski, Bonny Chow, Helene Morin, Shannon Awrey, Kriti Singh, Paul S. Rennie, Nada Lallous, Artem Cherkasov
Publikováno v:
Cells, Vol 11, Iss 18, p 2785 (2022)
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androgen receptor (AR) represents a major challenge for the treatment of prostate cancer patients. To address this challenge, we have developed a novel clas
Externí odkaz:
https://doaj.org/article/4aa1ebf257e04f9f8d6c4c6190d87376
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 6, Pp 12496-12519 (2013)
Recurrent, metastatic prostate cancer continues to be a leading cause of cancer-death in men. The androgen receptor (AR) is a modular, ligand-inducible transcription factor that regulates the expression of genes that can drive the progression of this
Externí odkaz:
https://doaj.org/article/66635d83321a4fb3a74a021db538c547
Autor:
Kriti Singh, Ravi S. N. Munuganti, Nada Lallous, Kush Dalal, Ji Soo Yoon, Aishwariya Sharma, Takeshi Yamazaki, Artem Cherkasov, Paul S. Rennie
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 2, p 579 (2018)
Estrogen receptor-α positive (ERα+) breast cancers represent 75% of all invasive breast cancer cases, while de novo or acquired resistance to ER-directed therapy is also on the rise. Numerous factors contribute to this phenomenon including the rece
Externí odkaz:
https://doaj.org/article/ee9b866e395641ff9bbee84bc70d2958
Autor:
Paul S. Rennie, Artem Cherkasov, Scott M. Dehm, Daniel T. Gewirth, Martin E. Gleave, Eric LeBlanc, Mani Roshan-Moniri, Kevin J. Tam, Huifang Li, Fuqiang Ban, Ronnie Tse, Deniz Ozistanbullu, Hendrik Borgmann, Nada Lallous, Rendong Yang, Aishwariya Sharma, Nanette S. Que, Meixia Che, Kush Dalal
Supplementary Table S1: Cloning and RT-PCR primers used in this study; Supplementary Figure S1: Luciferase and cell viability experiments with MR49C and PC3 cells; Supplementary Figure S2: ITC control experiment between AR-DBD and dsDNA; Supplementar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3667a690ec42f1ddca067d978fc3db
https://doi.org/10.1158/1535-7163.22508866.v1
https://doi.org/10.1158/1535-7163.22508866.v1
Autor:
Lindsay DeVorkin, Juntao (Matt) Mai, Kate Caldwell, Tim Jacobs, Raffi Tonikian, Karine Herve, Yuri Hwang, Cristina Faralla, Wei Wei, Emma Lathouwers, Rhys Chappell, Stefan Hannie, Katherine Lam, Harveer Dhupar, Tran Tran, Melissa Cid, Lena Bolten, Tova Pinsky, Ping Xiang, Courtenay Lai, Ahn Lee, Patrick Chan, Jasmine Chin, Aaron Yamniuk, Kush Dalal, Bryan Barnhart
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Juntao (Matt) Mai, Kate Caldwell, Lindsay DeVorkin, Grace P. Leung, Karine Herve, Yuri Hwang, Cristina Faralla, Wei Wei, Emma Lathouwers, Valentine de Puyraimond, Lauren Clifford, Rhys S. Chappell, Stefan Hannie, Katherine J. Lam, Harveer Dhupar, Tran N. Tran, Melissa Cid, Lena M. Bolten, Tova Pinsky, Ping Xiang, Courteney Lai, Ahn Lee, Vivian Z. Li, Patrick Chan, Jasmine Chin, Steve Booth, Amy C. Lee, Stephanie Masterman, Sherie Duncan, Aaron Yamniuk, Kush Dalal, Tim M. Jacobs, Raffi Tonikian, Bryan C. Barnhart
Publikováno v:
Cancer Research. 83:1886-1886
In this study, we describe the characterization and validation of a diverse panel of fully human CD3-binding antibodies, including hundreds of human and cyno cross-reactive binders. We used two proof-of-concept TCE targets to demonstrate that this pa