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Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice.

Autor: Gatti DM; The Jackson Laboratory, Bar Harbor, Maine, United States of America., Tyler AL; The Jackson Laboratory, Bar Harbor, Maine, United States of America., Mahoney JM; The Jackson Laboratory, Bar Harbor, Maine, United States of America., Churchill GA; The Jackson Laboratory, Bar Harbor, Maine, United States of America., Yener B; Rensselaer Polytechnic Institute, Troy, New York, United States of America., Koyuncu D; Rensselaer Polytechnic Institute, Troy, New York, United States of America., Gurcan MN; Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America., Niazi MK; Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America., Tavolara T; Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America., Gower A; Clinical and Translational Science Institute, Boston University, Boston, Massachusetts, United States of America., Dayao D; Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America., McGlone E; Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America., Ginese ML; Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America., Specht A; Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America., Alsharaydeh A; Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Tessier PA; Department of Microbiology and Immunology, Laval University School of Medicine, Quebec, Canada., Kurtz SL; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America., Elkins KL; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America., Kramnik I; National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, United States of America., Beamer G; Texas Biomedical Research Institute, San Antonio, Texas, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2024 Jun 11; Vol. 20 (6), pp. e1011915. Date of Electronic Publication: 2024 Jun 11 (Print Publication: 2024).

Host Genetic Background Influences BCG-Induced Antibodies Cross-Reactive to SARS-CoV-2 Spike Protein.

Autor: Specht AG; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Ginese M; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Kurtz SL; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA., Elkins KL; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA., Specht H; Department of Bioengineering and Barnett Institute, Northeastern University, Boston, MA 02115, USA., Beamer G; Texas Biomedical Research Institute, San Antonio, TX 78227, USA.

Publikováno v: Vaccines [Vaccines (Basel)] 2024 Feb 26; Vol. 12 (3). Date of Electronic Publication: 2024 Feb 26.

Transcriptional signatures measured in whole blood correlate with protection against tuberculosis in inbred and outbred mice.

Autor: Kurtz SL; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America., Rydén P; Department of Mathematics and Mathematical Statistics, Umeå University, Umeå, Sweden., Elkins KL; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.

Publikováno v: PloS one [PLoS One] 2023 Aug 03; Vol. 18 (8), pp. e0289358. Date of Electronic Publication: 2023 Aug 03 (Print Publication: 2023).

Deficiency in CCR2 increases susceptibility of mice to infection with an intracellular pathogen, Francisella tularensis LVS, but does not impair development of protective immunity.

Autor: Kurtz SL; Laboratory of Mucosal Pathogens and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States of America., De Pascalis R; Laboratory of Mucosal Pathogens and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States of America., Meierovics AI; Laboratory of Mucosal Pathogens and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States of America., Elkins KL; Laboratory of Mucosal Pathogens and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States of America.

Publikováno v: PloS one [PLoS One] 2021 Mar 24; Vol. 16 (3), pp. e0249142. Date of Electronic Publication: 2021 Mar 24 (Print Publication: 2021).