Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia.

Autor: Modak RV; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., de Oliveira Rebola KG; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., McClatchy J; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Mohammadhosseini M; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Damnernsawad A; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon.; Department of Biology, Faculty of Science, Mahidol University, Bangkok, Thailand., Kurtz SE; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Eide CA; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Wu G; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Laderas T; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Nechiporuk T; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Gritsenko MA; Pacific Northwest National Laboratory, Richland, Washington., Hansen JR; Pacific Northwest National Laboratory, Richland, Washington., Hutchinson C; Pacific Northwest National Laboratory, Richland, Washington., Gosline SJC; Pacific Northwest National Laboratory, Richland, Washington.; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, Oregon., Piehowski P; Pacific Northwest National Laboratory, Richland, Washington., Bottomly D; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Short N; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas., Rodland K; Pacific Northwest National Laboratory, Richland, Washington., McWeeney SK; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Tyner JW; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Agarwal A; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 May 15; Vol. 30 (10), pp. 2245-2259.

Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy.

Autor: Eide CA; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Kurtz SE; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Kaempf A; Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Long N; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Joshi SK; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Nechiporuk T; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Huang A; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Dibb CA; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Taylor A; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Bottomly D; Division of Bioinformatics and Computational Biomedicine, Department of Medical Informatics and Clinical Epidemiology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., McWeeney SK; Division of Bioinformatics and Computational Biomedicine, Department of Medical Informatics and Clinical Epidemiology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Minnier J; Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Lachowiez CA; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Saultz JN; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Swords RT; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Agarwal A; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Chang BH; Division of Pediatric Hematology and Oncology, Knight Cancer Institute, Doernbecher Children's Hospital, Oregon Health and Science University, Portland, Oregon., Druker BJ; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Tyner JW; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Department of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.

Publikováno v: Blood cancer discovery [Blood Cancer Discov] 2023 Nov 01; Vol. 4 (6), pp. 452-467.

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x L , Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.

Autor: Balachander SB; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Criscione SW; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Byth KF; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Cidado J; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Adam A; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Lewis P; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Macintyre T; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Wen S; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Lawson D; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Burke K; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Lubinski T; Translational Science, Oncology R&D, AstraZeneca, Boston, Massachusetts., Tyner JW; Division of Hematology & Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Ashland, Oregon., Kurtz SE; Division of Hematology & Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Ashland, Oregon., McWeeney SK; Division of Biostatistics, Department of Public Health and Preventive Medicine, Knight Cancer Institute, Oregon Health and Science University, Ashland, Oregon., Varnes J; Chemistry, Oncology R&D, AstraZeneca, Boston, Massachusetts., Diebold RB; Chemistry, Oncology R&D, AstraZeneca, Boston, Massachusetts., Gero T; Chemistry, Oncology R&D, AstraZeneca, Boston, Massachusetts., Ioannidis S; Chemistry, Oncology R&D, AstraZeneca, Boston, Massachusetts., Hennessy EJ; Chemistry, Oncology R&D, AstraZeneca, Boston, Massachusetts., McCoull W; Chemistry, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Saeh JC; Chemistry, Oncology R&D, AstraZeneca, Boston, Massachusetts., Tabatabai A; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Tavana O; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Su N; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts., Schuller A; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Garnett MJ; Wellcome Sanger Institute, Hinxton, United Kingdom., Jaaks P; Wellcome Sanger Institute, Hinxton, United Kingdom., Coker EA; Wellcome Sanger Institute, Hinxton, United Kingdom., Gregory GP; School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia., Newbold A; Peter MacCallum Cancer Centre, Melbourne, Australia., Johnstone RW; Peter MacCallum Cancer Centre, Melbourne, Australia., Gangl E; DMPK, Oncology R&D, AstraZeneca, Boston, Massachusetts., Wild M; DMPK, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Zinda M; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Secrist JP; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts., Davies BR; Projects, Oncology R&D, AstraZeneca, Cambridge, United Kingdom. Barry.Davies@astrazeneca.com Frank.Gibbons@astrazeneca.com., Fawell SE; Early Oncology R&D, AstraZeneca, Boston, Massachusetts., Gibbons FD; DMPK, Oncology R&D, AstraZeneca, Boston, Massachusetts. Barry.Davies@astrazeneca.com Frank.Gibbons@astrazeneca.com.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Dec 15; Vol. 26 (24), pp. 6535-6549. Date of Electronic Publication: 2020 Sep 28.

Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.

Autor: Bottomly D; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Long N; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Schultz AR; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Kurtz SE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Tognon CE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Johnson K; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Abel M; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Agarwal A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Avaylon S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Benton E; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Blucher A; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Borate U; Division of Hematology, Department of Internal Medicine, James Cancer Center, Ohio State University, Columbus, OH 43210, USA., Braun TP; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Brown J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Bryant J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Burke R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Carlos A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA., Chang BH; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology and Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA., Cho HJ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA., Christy S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Coblentz C; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Cohen AM; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., d'Almeida A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Cook R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Danilov A; Department of Hematology and Hematopoietic Stem Cell Transplant, City of Hope National Medical Center, Duarte, CA 91010, USA., Dao KT; Astex Pharmaceuticals, Cambridge, CB4 0QA, UK., Degnin M; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Dibb J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Eide CA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., English I; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Hagler S; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Harrelson H; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Henson R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA., Ho H; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Joshi SK; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Junio B; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Kaempf A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR 97239, USA., Kosaka Y; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA., Laderas T; DNA Nexus, Mountain View, CA 94040, USA., Lawhead M; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Lee H; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Leonard JT; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Lin C; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA., Lind EF; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA., Liu SQ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Lo P; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Loriaux MM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Pathology, Oregon Health & Science University, Portland, OR 97239, USA., Luty S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Maxson JE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Macey T; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Martinez J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Minnier J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR 97239, USA; OHSU-PSU School of Public Health, VA Portland Health Care System, Oregon Health & Science University, Portland, OR 97239, USA., Monteblanco A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Mori M; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Morrow Q; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Nelson D; High-Throughput Screening Services Laboratory, Oregon State University, Corvallis, OR 97331, USA., Ramsdill J; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Rofelty A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Rogers A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Romine KA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Ryabinin P; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Saultz JN; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Sampson DA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Savage SL; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Schuff R; Ochin Inc., Portland, OR 97228, USA., Searles R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA., Smith RL; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Spurgeon SE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Sweeney T; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Swords RT; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Thapa A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Thiel-Klare K; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Traer E; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Wagner J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Wilmot B; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Wolf J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Wu G; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Yates A; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Zhang H; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Cogle CR; Department of Medicine, Division of Hematology and Oncology, University of Florida, Gainesville, FL 32610, USA., Collins RH; Department of Internal Medicine/ Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8565, USA., Deininger MW; Division of Hematology & Hematologic Malignancies, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Hourigan CS; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20814-1476, USA., Jordan CT; Division of Hematology, University of Colorado, Denver, CO 80045, USA., Lin TL; Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas, Kansas City, KS 66205, USA., Martinez ME; Clinical Research Services, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA., Pallapati RR; Clinical Research Services, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA., Pollyea DA; Division of Hematology, University of Colorado, Denver, CO 80045, USA., Pomicter AD; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Watts JM; Division of Hematology, Department of Medicine, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA., Weir SJ; Department of Cancer Biology, Division of Medical Oncology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA., Druker BJ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: drukerb@ohsu.edu., McWeeney SK; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: mcweeney@ohsu.edu., Tyner JW; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: tynerj@ohsu.edu.

Publikováno v: Cancer cell [Cancer Cell] 2022 Aug 08; Vol. 40 (8), pp. 850-864.e9. Date of Electronic Publication: 2022 Jul 21.

Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia.

Autor: Kurtz SE; Division of Hematology & Medical Oncology.; Division of Oncological Sciences., Eide CA; Division of Hematology & Medical Oncology., Kaempf A; Biostatistics Shared Resource, and., Long N; Division of Hematology & Medical Oncology., Bottomly D; Division of Bioinformatics & Computational Biomedicine, Department of Medical Informatics and Clinical Epidemiology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Nikolova O; Division of Oncological Sciences., Druker BJ; Division of Hematology & Medical Oncology.; Division of Oncological Sciences., McWeeney SK; Division of Bioinformatics & Computational Biomedicine, Department of Medical Informatics and Clinical Epidemiology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Chang BH; Division of Pediatric Hematology and Oncology, Knight Cancer Institute, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, Oregon; and., Tyner JW; Division of Hematology & Medical Oncology.; Department of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Agarwal A; Division of Hematology & Medical Oncology.; Division of Oncological Sciences.; Department of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

Publikováno v: Blood advances [Blood Adv] 2022 May 24; Vol. 6 (10), pp. 3062-3067.