Solution Structure of Kurtoxin: A Gating Modifier Selective for Cav3 Voltage-Gated Ca2+ Channels

Autor: Chanhyung Bae, Chul Won Lee, Jae Ha Ryu, Jae Il Kim, Ha Hyung Kim, Jaeho Lee, Kenton J. Swartz, Toshiyuki Kohno

Publikováno v: Biochemistry

Kurtoxin is a 63-amino acid polypeptide isolated from the venom of the South African scorpion Parabuthus transvaalicus. It is the first and only peptide ligand known to interact with Cav3 (T-type) voltage-gated Ca(2+) channels with high affinity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6c6a70f466f2d88a383e388ef24ca8
https://doi.org/10.1021/bi201633j

Activation of voltage-gated Na+ and Ca2+ channels is required for glutamate release from retinal glial cells implicated in cell volume regulation

Autor: Katja Krügel, Thomas Pannicke, Margrit Hollborn, Peter Wiedemann, Andreas Reichenbach, Antje Wurm, Regina Linnertz, Andreas Bringmann, Wolfgang Härtig, Ianors Iandiev

Publikováno v: Neuroscience. 188:23-34

Gliotransmitters such as glutamate and ATP play an essential role in the prevention of the osmotic swelling of retinal glial (Muller) cells. It has been shown that vascular endothelial growth factor (VEGF) induces a Ca²⁺-dependent release of gluta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcc30394eabf0855481712ad5282c09d
https://doi.org/10.1016/j.neuroscience.2011.04.058

Inhibition of T-Type Calcium Channels Protects Neurons from Delayed Ischemia-Induced Damage

Autor: Dominique Muller, Mircea Bancila, Alain Bloc, Irina Nikonenko, Philippe Bijlenga

Publikováno v: Molecular Pharmacology, Vol. 68, No 1 (2005) pp. 84-89

Intracellular calcium increase is an early key event triggering ischemic neuronal cell damage. The role of T-type voltage-gated calcium channels in the neuronal response to ischemia, however, has never been studied. Using an in vitro model of ischemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d8a4099a34bd158da7037a6d1ce50c
https://doi.org/10.1124/mol.104.010066

Scorpion toxins that block T-type Ca2+ channels in spermatogenic cells inhibit the sperm acrosome reaction

Autor: José L. De la Vega-Beltrán, Timoteo Olamendi-Portugal, Karin Dyason, Jurg van der Walt, Alberto Darszon, Ricardo Felix, Lourival D. Possani, Ignacio López-González

Publikováno v: Biochemical and Biophysical Research Communications. 300:408-414

The acrosome reaction (AR) is a Ca(2+)-dependent event required for sperm to fertilize the egg. The activation of T-type voltage-gated Ca(2+) channels plays a key role in the induction of this process. This report describes the actions of two toxins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83fb536f7b956d08fe3c3896617198a
https://doi.org/10.1016/s0006-291x(02)02859-0

Voltage-activated Ca2+ channels in rat renal afferent and efferent myocytes: no evidence for the T-type Ca2+ current

Autor: Sergey V. Smirnov, Rodger Loutzenhiser, Kathy Loutzenhiser

Publikováno v: Smirnov, S V, Loutzenhizer, K & Loutzenhiser, R 2013, ' Voltage-activated Ca 2+ channels in rat renal afferent and efferent myocytes: no evidence for the T-type Ca 2+ current ', Cardiovascular Research, vol. 97, no. 2, pp. 293-301 . https://doi.org/10.1093/cvr/cvs310

AIMS: Based on indirect methods, it has been suggested that both L- and T-type Ca(2+) channels mediate signalling in the renal afferent arteriole and that T-type Ca(2+) channels are involved in signalling in the efferent arteriole. However, Ca(2+) cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc0ea2e644ba406ef8bce0ddbb74f53
https://purehost.bath.ac.uk/ws/files/9381971/4999_ACCEPTED_MS.pdf