Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kurtis Eisermann"'
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0128495 (2015)
The androgen receptor (AR) is a member of the steroid receptor superfamily that regulates gene expression in a ligand-dependent manner. The NTD of the AR plays a key role in AR transactivation including androgen-independent activation of the AR in ca
Externí odkaz:
https://doaj.org/article/b2c147d51cd74b2da50c57502c087db6
Autor:
Laura E Pascal, Junkui Ai, Khalid Z Masoodi, Yujuan Wang, Dan Wang, Kurtis Eisermann, Lora H Rigatti, Katherine J O'Malley, Hei M Ma, Xinhui Wang, Javid A Dar, Anil V Parwani, Brian W Simons, Michael M Ittman, Luyuan Li, Benjamin J Davies, Zhou Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79542 (2013)
ELL-associated factor 2 (EAF2) is an androgen-responsive tumor suppressor frequently deleted in advanced prostate cancer that functions as a transcription elongation factor of RNA Pol II through interaction with the ELL family proteins. EAF2 knockout
Externí odkaz:
https://doaj.org/article/2c2f1098dfe742f993dd09a4cac54f86
Autor:
Paul A. Johnston, Mustafa Zahrittin Kazancioglu, Benjamin R. Eyer, Erica Parrinello, Dan Wang, Joel B. Nelson, Jianhua Zhou, Kurtis Eisermann, Erin M. Skoda, Zhou Wang, James K. Johnson, Katherine J. O’Malley, Peter Wipf
Publikováno v:
ACS Medicinal Chemistry Letters. 7:785-790
After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure-activity relationship (SAR) purposes and analogues were synthesized and evaluated in a cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a59f3c6c59672d36f1d453a01e369c
https://doi.org/10.1021/acsmedchemlett.6b00186
https://doi.org/10.1021/acsmedchemlett.6b00186
Autor:
Peter Wipf, Katherine J. O’Malley, Zhenyu Yang, Alex N Kenefake, Khalid Z. Masoodi, Kurtis Eisermann, Zhou Wang, Laura E. Pascal, Firuz G. Feturi, Erica Parrinello, Javid A. Dar, Minh M Nguyen, Paul A. Johnston, Joel B. Nelson
Publikováno v:
Endocrinology. 158(10)
The androgen receptor (AR) plays a critical role in the development of castration-resistant prostate cancer (CRPC) as well as in the resistance to the second-generation AR antagonist enzalutamide and the selective inhibitor of cytochrome P450 17A1 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20e84d4c7a79f85bf2bfb881bda5f0d
https://pubmed.ncbi.nlm.nih.gov/28977599
https://pubmed.ncbi.nlm.nih.gov/28977599
Autor:
Gail Fraizer, Kurtis Eisermann
Publikováno v:
Cancers
Cancers, Vol 9, Iss 4, p 32 (2017)
Cancers, Vol 9, Iss 4, p 32 (2017)
Prostate cancer progression is controlled by the androgen receptor and new blood vessel formation, or angiogenesis, which promotes metastatic prostate cancer growth. Angiogenesis is induced by elevated expression of vascular endothelial growth factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cefb6606697b43c513e166ec73040e
http://europepmc.org/articles/PMC5406707
http://europepmc.org/articles/PMC5406707
Autor:
Paul A. Johnston, Khalid Z. Masoodi, Zhou Wang, Erica Parrinello, Joel B. Nelson, Javid A. Dar, Kurtis Eisermann, Laura E. Pascal, Peter Wipf, Yadong Xu, Junkui Ai
Publikováno v:
Molecular cancer therapeutics. 16(10)
The androgen receptor (AR) is a ligand-dependent transcription factor that controls the expression of androgen-responsive genes. A key step in androgen action, which is amplified in castration-resistant prostate cancer (CRPC), is AR nuclear transloca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10042dc86595f2c6786393619ca17d4c
https://pubmed.ncbi.nlm.nih.gov/28655783
https://pubmed.ncbi.nlm.nih.gov/28655783
Autor:
Naoki Yoshimura, Zhou Wang, Katherine Hrebinko, Joel B. Nelson, Nicolas A. Stewart, Kurtis Eisermann, Anil V. Parwani, Katherine J. O’Malley, Tsuyoshi Majima, Marie Acquafondata, Laura E. Pascal, Lara E. Graham
Publikováno v:
The Prostate. 74:892-900
BACKGROUND Benign prostatic hyperplasia (BPH) is an age-related disease frequently associated with lower urinary tract symptoms (LUTS) that involves hyperplasia of both epithelial and stromal cells. Stromal fibrosis is a distinctive feature of BPH, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6d7ef5e1773d5f5033ba304e17ef86e
https://doi.org/10.1002/pros.22807
https://doi.org/10.1002/pros.22807
Autor:
Khalid Z. Masoodi, Dan Wang, Junkui Ai, Sharanya D. Sampath-Kumar, Tyler Severance, Kurtis Eisermann, Javid A. Dar, Zhou Wang
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 139:16-24
Nucleocytoplasmic trafficking of the androgen receptor (AR) represents an essential step in androgen action. To determine whether the amino-terminal domain (NTD) contains potential nuclear import and/or export signals, deletion mutants of the NTD tag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375469d2ba7f8ef533157d91c60ee99f
https://doi.org/10.1016/j.jsbmb.2013.09.013
https://doi.org/10.1016/j.jsbmb.2013.09.013
Autor:
Nirmala Ghimirey, Sarah Nock, Sony Pandey, Gail Fraizer, Anton Bazarov, Steven J. Kuerbitz, Adina Brett-Morris, Kurtis Eisermann
Publikováno v:
Wilms Tumor ISBN: 9780994438119
Although initial discoveries of Wilms tumor 1 (WT1) expression in extrarenal disease generated controversy, we and others have examined WT1 expression in non-Wilms cancers and have demonstrated that the WT1(A) isoform, lacking the lysine-threonine-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77b63f947d7e988400a3f630f2e65bcd
https://doi.org/10.15586/codon.wt.2016.ch14
https://doi.org/10.15586/codon.wt.2016.ch14
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 7, p e0128495 (2015)
PLoS ONE, Vol 10, Iss 7, p e0128495 (2015)
The androgen receptor (AR) is a member of the steroid receptor superfamily that regulates gene expression in a ligand-dependent manner. The NTD of the AR plays a key role in AR transactivation including androgen-independent activation of the AR in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe582241ab5a56025a4f4bf8f894343
http://europepmc.org/articles/PMC4503479
http://europepmc.org/articles/PMC4503479