Výsledky vyhledávání - "Kurtis Biggs"

The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo

Autor: Christian C. Fritz, Julian Adams, Melissa Pink, Jie Ge, Michael Curtis, Emmanuel Normant, Thomas T. Tibbits, James R. Porter, Andrew Wylie, Mark Douglas, Kurtis Biggs, Kip A. West, Vito J. Palombella, Alice R. Lim

Publikováno v: Molecular cancer therapeutics. 8(12)

IPI-504, a water-soluble ansamycin analogue currently being investigated in clinical trials, is a potent inhibitor of the protein chaperone heat shock protein 90 (Hsp90). Inhibition of Hsp90 by IPI-504 triggers the degradation of important oncogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be9a591308cbb7ce46be845eaba39b7
https://pubmed.ncbi.nlm.nih.gov/19952119

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