Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kurtis, Mengham"'
Autor:
Mahmoud B. Maina, Gunasekhar Burra, Youssra K. Al-Hilaly, Kurtis Mengham, Kate Fennell, Louise C. Serpell
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101537- (2020)
Summary: Dityrosine (DiY), via the cross-linking of tyrosine residues, is a marker of protein oxidation, which increases with aging. Amyloid-β (Aβ) forms DiY in vitro and DiY-cross-linked Aβ is found in the brains of patients with Alzheimer diseas
Externí odkaz:
https://doaj.org/article/4f3367717ded4dfe87b1faeb3c86248f
Autor:
Karen E. Marshall, Kurtis Mengham, Matthew C. Spink, Lyra Vania, Hannah Jane Pollard, Michele C. Darrow, Elizabeth Duke, Maria Harkiolaki, Louise C. Serpell
Protein misfolding is common to neurodegenerative diseases (NDs) including Alzheimer’s disease (AD), which is characterized by self-assembly and accumulation of Amyloid-beta in the brain. Furthermore, impaired proteostatic mechanisms have been impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab65cb22dc489115d6b465df851b1325
https://doi.org/10.21203/rs.3.rs-2189678/v1
https://doi.org/10.21203/rs.3.rs-2189678/v1
Autor:
Youssra K, Al-Hilaly, Karen E, Marshall, Liisa, Lutter, Luca, Biasetti, Kurtis, Mengham, Charles R, Harrington, Wei-Feng, Xue, Claude M, Wischik, Louise C, Serpell
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
Tau is a natively unfolded protein that contributes to the stability of microtubules. Under pathological conditions such as Alzheimer's disease (AD), tau protein misfolds and self-assembles to form paired helical filaments (PHFs) and straight filamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5ebe12eb3fbc8d0128307e019baa14d
https://pubmed.ncbi.nlm.nih.gov/36310203
https://pubmed.ncbi.nlm.nih.gov/36310203
Autor:
Youssra K. Al-Hilaly, Karen E. Marshall, Liisa Lutter, Luca Biasetti, Kurtis Mengham, Charles R. Harrington, Wei-Feng Xue, Claude M. Wischik, Louise C. Serpell
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfec2dab062f29bdce33aab424c72ec1
https://doi.org/10.1007/978-1-0716-2597-2_12
https://doi.org/10.1007/978-1-0716-2597-2_12
Autor:
Kurtis Mengham, Youssra Al-Hilaly, Sebastian Oakley, Kamillia Kasbi, Mahmoud B. Maina, Louise C. Serpell
Publikováno v:
Essays in biochemistry.
Tau is an intrinsically disordered protein that has the ability to self-assemble to form paired helical and straight filaments in Alzheimer’s disease, as well as the ability to form additional distinct tau filaments in other tauopathies. In the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea6ec910c1216410f674d92d062b398
https://pubmed.ncbi.nlm.nih.gov/36373666
https://pubmed.ncbi.nlm.nih.gov/36373666
Autor:
Mahmoud B. Maina, Youssra K. Al-Hilaly, Sebastian Oakley, Gunashekar Burra, Tahmida Khanon, Luca Biasetti, Kurtis Mengham, Karen Marshall, Janet E. Rickard, Charles R. Harrington, Claude M. Wischik, Louise C. Serpell
A characteristic hallmark of Alzheimer’s Disease (AD) is the pathological aggregation and deposition of tau into paired helical filaments (PHF) in neurofibrillary tangles (NFTs). Oxidative stress is an early event during AD pathogenesis and is asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51fb3a085481601be4853471a36e72a8
https://doi.org/10.1101/2022.05.28.493839
https://doi.org/10.1101/2022.05.28.493839
Autor:
Mahmoud B, Maina, Youssra K, Al-Hilaly, Sebastian, Oakley, Gunasekhar, Burra, Tahmida, Khanom, Luca, Biasetti, Kurtis, Mengham, Karen, Marshall, Charles R, Harrington, Claude M, Wischik, Louise C, Serpell
Publikováno v:
Journal of Molecular Biology. 434:167785
A characteristic hallmark of Alzheimer's Disease (AD) is the pathological aggregation and deposition of tau into paired helical filaments (PHF) in neurofibrillary tangles (NFTs). Oxidative stress is an early event during AD pathogenesis and is associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f978cd7ad36ec81e6c1eaeff6c26a10
https://doi.org/10.1016/j.jmb.2022.167785
https://doi.org/10.1016/j.jmb.2022.167785
Autor:
Youssra K. Al-Hilaly, Mahmoud Bukar Maina, Kurtis Mengham, Gunasekhar Burra, Kate Fennell, Louise C. Serpell
Publikováno v:
iScience
iScience, Vol 23, Iss 10, Pp 101537-(2020)
iScience, Vol 23, Iss 10, Pp 101537-(2020)
Summary Dityrosine (DiY), via the cross-linking of tyrosine residues, is a marker of protein oxidation, which increases with aging. Amyloid-β (Aβ) forms DiY in vitro and DiY-cross-linked Aβ is found in the brains of patients with Alzheimer disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709d6955bac606c587f2a7d270c0c837
https://pubmed.ncbi.nlm.nih.gov/33083713
https://pubmed.ncbi.nlm.nih.gov/33083713
Autor:
Gunasekhar K. Burra, Youssra A. Al-Hilaly, Mahmoud Bukar Maina, Louise C. Serpell, Kurtis Mengham
Multiple chemical reactions, such as the production of reactive oxygen species (ROS) can lead to dityrosine (DiY) formation via the cross-linking of closely spaced tyrosine residues and this can serve as a marker for aging. Amyloid-β (Aβ) has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e327e60e1b6f4a18573735e0fd36ea