Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kurt W. Vogel"'
Autor:
Brian J. Druker, Michael W. Deininger, Jeffrey W. Tyner, John Apgar, Dennis R. Koop, Kurt W. Vogel, Bryan D. Marks, Steven M. Riddle, Jenny Luo, Huihong You, Kara J. Johnson, Dorian H. LaTocha, Ryan J. MacKenzie, Matthew S. Zabriskie, Lauren T. Adrian, Anupriya Agarwal, Christopher A. Eide, Thomas O'Hare
PDF file - 1469K, Different ABL TKIs demonstrate potency differences in relative cellular and biochemical target inhibition (S1); Incomplete restoration of BCR-ABL signaling activity following washout of dasatinib or ponatinib tracks with intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bb2f349dbdbd12daa46b5865710272
https://doi.org/10.1158/0008-5472.22396247
https://doi.org/10.1158/0008-5472.22396247
Autor:
Brian J. Druker, Michael W. Deininger, Jeffrey W. Tyner, John Apgar, Dennis R. Koop, Kurt W. Vogel, Bryan D. Marks, Steven M. Riddle, Jenny Luo, Huihong You, Kara J. Johnson, Dorian H. LaTocha, Ryan J. MacKenzie, Matthew S. Zabriskie, Lauren T. Adrian, Anupriya Agarwal, Christopher A. Eide, Thomas O'Hare
PDF file - 337K, Summary of mean fluorescence intensity values for levels of CrkL and STAT5 phosphorylation in K562 cells following acute ABL TKI exposure followed by standard and expanded washout (S1); Kinase:inhibitor dissociation off-rates for ABL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464ff7a97c638799f3fd2f9fd2378704
https://doi.org/10.1158/0008-5472.22396238.v1
https://doi.org/10.1158/0008-5472.22396238.v1
Autor:
Brian J. Druker, Michael W. Deininger, Jeffrey W. Tyner, John Apgar, Dennis R. Koop, Kurt W. Vogel, Bryan D. Marks, Steven M. Riddle, Jenny Luo, Huihong You, Kara J. Johnson, Dorian H. LaTocha, Ryan J. MacKenzie, Matthew S. Zabriskie, Lauren T. Adrian, Anupriya Agarwal, Christopher A. Eide, Thomas O'Hare
PDF file - 45K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2e7b60dba00e64f41fe83e32b81c9f
https://doi.org/10.1158/0008-5472.22396250.v1
https://doi.org/10.1158/0008-5472.22396250.v1
Autor:
Spencer B Hermanson, Coby B Carlson, Steven M Riddle, Jing Zhao, Kurt W Vogel, R Jeremy Nichols, Kun Bi
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43580 (2012)
Mutations in the leucine-rich repeat kinase-2 (LRRK2) have been linked to Parkinson's disease. Recent studies show that inhibition of LRRK2 kinase activity decreased the level of phosphorylation at its own Ser910 and Ser935, indicating that these sit
Externí odkaz:
https://doaj.org/article/6312974e5373462aa4657fa85fc72947
Autor:
Heather Sahm, Zhong Yin Zhang, Todd A. Stone, Sheng Zhang, Kurt W. Vogel, Mu Wang, Dali Liu, Mark R. Cookson, Jingling Liao, Christopher Burlak, Quyen Q. Hoang, R. Jeremy Nichols, Mark Federici, Chun Xiang Wu, Steve Riddle
Publikováno v:
Proceedings of the National Academy of Sciences. 111:4055-4060
Mutation in leucine-rich-repeat kinase 2 (LRRK2) is a common cause of Parkinson disease (PD). A disease-causing point mutation R1441H/G/C in the GTPase domain of LRRK2 leads to overactivation of its kinase domain. However, the mechanism by which this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9656b51240703e2457e787d01c943f
https://doi.org/10.1073/pnas.1323285111
https://doi.org/10.1073/pnas.1323285111
Autor:
Kurt W. Vogel, Thomas M. Roberts, Nathanael S. Gray, Coby B. Carlson, Jing Ni, Jean J. Zhao, Qingsong Liu, Cyril H. Benes, Michael J. Eck, Steve Riddle, Thanh Von, Shaozhen Xie
Publikováno v:
Cancer Discovery. 2:425-433
Genetic approaches have shown that the p110β isoform of class Ia phosphatidylinositol-3-kinase (PI3K) is essential for the growth of PTEN-null tumors. Thus, it is desirable to develop p110β-specific inhibitors for cancer therapy. Using a panel of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe478190648d245b98488dae11e4fb8
https://doi.org/10.1158/2159-8290.cd-12-0003
https://doi.org/10.1158/2159-8290.cd-12-0003
Publikováno v:
Expert Opinion on Drug Discovery. 6:701-712
Over the past decade, there has been an increased number of FDA approved small molecule kinase inhibitors for the treatment of cancer. This is due, in part, to an increased understanding of the fundamental aspects of kinase biology, coupled with adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43f8f7411ce8b8a4c23f9ca51d956c2
https://doi.org/10.1517/17460441.2011.575776
https://doi.org/10.1517/17460441.2011.575776
Publikováno v:
ASSAY and Drug Development Technologies. 7:348-355
The posttranslational modification of target substrates by the ubiquitin-like proteins, specifically the small ubiquitin-like modifier (SUMO), has emerged as an essential mechanism to regulate protein function and control intracellular trafficking. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76d825cd19756c1a4709c44792ae17f
https://doi.org/10.1089/adt.2008.0188
https://doi.org/10.1089/adt.2008.0188
Publikováno v:
Letters in Drug Design & Discovery. 5:416-422
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36478c2a37b72a0dec12e45dc6469f2e
https://doi.org/10.2174/157018008785777261
https://doi.org/10.2174/157018008785777261
Publikováno v:
Analytical Biochemistry. 372:189-197
We have developed a set of high-throughput screening (HTS)-compatible assays capable of measuring regulated, target-specific posttranslational modifications in a mammalian cell-based format. We chose the NFkappaB signal transduction cascade as a mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30d58fccfeada1a104974c99b055b1a
https://doi.org/10.1016/j.ab.2007.09.012
https://doi.org/10.1016/j.ab.2007.09.012