Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kurt W. Runge"'
Autor:
Kathleen L. Berkner, Kurt W. Runge
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5759 (2022)
Vitamin K-dependent (VKD) proteins undergo an unusual post-translational modification, which is the conversion of specific Glu residues to carboxylated Glu (Gla). Gla generation is required for the activation of VKD proteins, and occurs in the endopl
Externí odkaz:
https://doaj.org/article/33001140c5f94c10945ee77813dfc76b
Publikováno v:
F1000Research, Vol 7 (2018)
DNA double-strand breaks (DSBs) activate the DNA damage checkpoint machinery to pause or halt the cell cycle. Telomeres, the specific DNA-protein complexes at linear eukaryotic chromosome ends, are capped DSBs that do not activate DNA damage checkpoi
Externí odkaz:
https://doaj.org/article/0417e68b9cb641f0aeec88c8ad315a2a
Autor:
Mark A. Rishavy, Kevin W. Hallgren, Lee A. Wilson, James M. Hiznay, Kurt W. Runge, Kathleen L. Berkner
Publikováno v:
Blood. 140:1710-1722
γ-Glutamyl carboxylase (GGCX) generates multiple carboxylated Glus (Glas) in vitamin K–dependent (VKD) proteins that are required for their functions. GGCX is processive, remaining bound to VKD proteins throughout multiple Glu carboxylations, and
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac986⟩
Nucleic Acids Research, Vol. 50, no.20, p. 11682-11695 (2022)
Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac986⟩
Nucleic Acids Research, Vol. 50, no.20, p. 11682-11695 (2022)
Telomere elongation is coupled with genome replication, raising the question of the repair of short telomeres in post-mitotic cells. We investigated the fate of a telomere-repeat capped end that mimics a single short telomere in quiescent fission yea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f9aea5a998c6eb5a6d441267e39977
https://cnrs.hal.science/hal-03847177
https://cnrs.hal.science/hal-03847177
Autor:
Yanhui Li, Neil Molyneaux, Haitao Zhang, Gang Zhou, Carly Kerr, Mark D Adams, Kathleen L Berkner, Kurt W Runge
Publikováno v:
Nucleic acids research. 50(17)
Arrayed libraries of defined mutants have been used to elucidate gene function in the post-genomic era. Yeast haploid gene deletion libraries have pioneered this effort, but are costly to construct, do not reveal phenotypes that may occur with partia
Autor:
Kurt W Runge, Arthur J Lustig
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
Externí odkaz:
https://doaj.org/article/0fed40dd761a400192bf69ab775a039f
Autor:
Kevin W. Hallgren, Savita Singh, Kurt W. Runge, Kathleen L. Berkner, Lee Wilson, Mark A. Rishavy
Publikováno v:
Blood. 131:2826-2835
The anticoagulant warfarin inhibits the vitamin K oxidoreductase (VKORC1), which generates vitamin K hydroquinone (KH2) required for the carboxylation and consequent activation of vitamin K-dependent (VKD) proteins. VKORC1 produces KH2 in 2 reactions
Autor:
Michael Lajeunesse, Kurt W. Runge, Gang Zhou, Kathleen L. Berkner, Brittany N. Stawicki, Yalitza Lopez Corcino, Jinyu Wang, Yanhui Li, Nga Le
Publikováno v:
Genetics. 206:481-496
While the Mre11-Rad50-Nbs1 (MRN) complex has known roles in repair processes like homologous recombination and microhomology-mediated end-joining, its role in nonhomologous end-joining (NHEJ) is unclear as Saccharomyces cerevisiae, Schizosaccharomyce
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008335 (2019)
PLoS Genetics
PLoS Genetics
Genomic rearrangements (gross chromosomal rearrangements, GCRs) threatens genome integrity and cause cell death or tumor formation. At the terminus of linear chromosomes, a telomere-binding protein complex, called shelterin, ensures chromosome stabil