Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kurt W. Marek"'
Autor:
Kurt W. Marek, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 660-665 (2016)
Small companies working to develop products in the cardiovascular space face numerous challenges, from regulatory, intellectual property, and reimbursement barriers to securing funds to keep the lights on and reach the next development milestone. Mos
Externí odkaz:
https://doaj.org/article/830480bc671b49d7b2bf55f357dd1e64
Autor:
Kurt W. Marek, Stephanie D. Albin, Graeme W. Davis, Elizabeth S. Heckscher, Richard D. Fetter
Publikováno v:
Neuron. 55:859-873
NF-kappaB signaling has been implicated in neurodegenerative disease, epilepsy, and neuronal plasticity. However, the cellular and molecular activity of NF-kappaB signaling within the nervous system remains to be clearly defined. Here, we show that t
Publikováno v:
Nature. 426:559-563
Neurotransmission requires a balance of synaptic vesicle exocytosis and endocytosis. Synaptotagmin I (Syt I) is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis. Previous biochemical data suggest that Syt I may also funct
Autor:
Kurt W. Marek, Graeme W. Davis
Publikováno v:
Current Opinion in Neurobiology. 13:607-611
Molecular perturbations of neurons, including genetic knockout and transgenic approaches, have provided insight into the cellular processes underlying neuronal function and plasticity. A detailed understanding of how individual neurons participate in
Autor:
Graeme W. Davis, Kurt W. Marek
Publikováno v:
Neuron. 36(5):805-813
We demonstrate a noninvasive technique for protein photoinactivation using a transgenically encoded tag. A tetracysteine motif that binds the membrane-permeable fluorescein derivative 4′,5′-bis(1,3,2-dithioarsolan-2-yl)fluorescein (FlAsH) was eng
Publikováno v:
The Journal of Neuroscience. 20:8578-8584
Although both pre- and postsynaptic mechanisms have been implicated in the analgesia produced by μ-opioids at the spinal cord, it is not known under what conditions these different controls come into play. Because the μ-opioid receptor (MOR) can be
Publikováno v:
Glycobiology. 9:1263-1271
Formation of the dolichol oligosaccharide precursor is essential for the production of asparagine- (N-) linked oligosaccharides (N-glycans) in eukaryotic cells. The first step in precursor biosynthesis requires the enzyme UDP-GlcNAc: dolichol phospha
Autor:
Yung-Feng Liao, Kurt W. Marek, K. Panneerselvam, Jamey D. Marth, Michiko N. Fukuda, Hudson H. Freeze, Masayoshi Oh-Eda, Anita Lal, Kelley W. Moremen, Daniel Chui
Publikováno v:
Cell. 90:157-167
Alpha-mannosidase-II (alphaM-II) catalyzes the first committed step in the biosynthesis of complex asparagine-linked (N-linked) oligosaccharides (N-glycans). Genetic deficiency of alphaM-II should abolish complex N-glycan production as reportedly doe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 1, p e53965 (2013)
PLoS ONE, Vol 8, Iss 1, p e53965 (2013)
Postsynatptic density protein (PSD-95) is a 95 kDa scaffolding protein that assembles signaling complexes at synapses. Over-expression of PSD-95 in primary hippocampal neurons selectively increases synaptic localization of AMPA receptors; however, mi
Publikováno v:
Nature neuroscience
Neuronal differentiation is accomplished through cascades of intrinsic genetic factors initiated in neuronal progenitors by external gradients of morphogens. Activity was thought to be important only late in development, but recent evidence indicates