Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kurt Van Vloten"'
Autor:
Justin A. Caravella, Daliya Banerjee, Noel A. Powell, Jason D. Fontenot, Andres McKenzie, Istvan J. Enyedy, Victor Sukbong Hong, Douglas Marcotte, Laura Silvian, Jianhua Chao, Kurt Van Vloten
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2459-2463
RORγ plays a critical role in controlling a pro-inflammatory gene expression program in several lymphocyte lineages including T cells, γδ T cells, and innate lymphoid cells. RORγ-mediated inflammation has been linked to susceptibility to Crohn's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3136b750dc7319912bb39e7e65933a62
https://doi.org/10.1016/j.bmcl.2016.03.109
https://doi.org/10.1016/j.bmcl.2016.03.109
Autor:
Malcolm L. Gefter, Alexander L. Satz, Matthew C Oliff, Cecil E Rise, Sibongile Mataruse, Fan Li, Cynthia H. Chiu, John W. Cuozzo, Steven R. Skinner, Matthew A. Clark, Gang Yao, Kurt D Franzen, Paul Myers, Heather O’Keefe, Lujia Tang, Christopher S. Kollmann, Christopher P. Davie, Nils Jakob Vest Hansen, Neil R Carlson, Paolo A. Centrella, Michael Kelley, Patricia F Medeiros, Steven P Hale, Richard W. Wagner, Christopher C. Arico-Muendel, Dennis Benjamin, David I. Israel, Kurt van Vloten, G Joseph Franklin, Svetlana L. Belyanskaya, Jennifer L Svendsen, Kenneth E Lind, Raksha A. Acharya, Barry A. Morgan, Baoguang Zhao, Steffen Phillip Creaser, Malcolm J. Kavarana, Jinwei Jiang, Jeffrey A. Messer, Yun Ding
Publikováno v:
Nature Chemical Biology. 5:647-654
Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2643c1a620295ac72e51e7c637cb05cc
https://doi.org/10.1038/nchembio.211
https://doi.org/10.1038/nchembio.211
Autor:
Kevin Guertin, Tonika Bohnert, Tao Wang, Howard Jones, Edward Yin-Shiang Lin, Daliya Banerjee, Tina Talreja, Istvan J. Enyedy, Kurt Van Vloten, Douglas Marcotte, Jianhua Chao, Jason D. Fontenot
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(15)
The nuclear receptor RORγ plays a central role in controlling a pro-inflammatory gene expression program in several lymphocyte lineages including TH17 cells. RORγ-dependent inflammation has been implicated in the pathogenesis of several major autoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92cf92a880de37c49e8dc3ae5446756
https://pubmed.ncbi.nlm.nih.gov/26048789
https://pubmed.ncbi.nlm.nih.gov/26048789
Autor:
Joanne L. Viney, Victor Hong, Arthur G. Taveras, Chi-Chi Peng, Daliya Banerjee, Kevin Guertin, Laura Silvian, Richard H. Hutchings, Howard Jones, Douglas Marcotte, Liaomin Peng, Noel A. Powell, Kevin Little, Jianhua Chao, Tonika Bohnert, Kurt Van Vloten, Istvan J. Enyedy, Jason D. Fontenot
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(15)
RORγt is a pivotal regulator of a pro-inflammatory gene expression program implicated in the pathology of several major human immune-mediated diseases. Evidence from mouse models demonstrates that genetic or pharmacological inhibition of RORγ activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12513df04b12ba87745ee6c80e88a93
https://pubmed.ncbi.nlm.nih.gov/26048806
https://pubmed.ncbi.nlm.nih.gov/26048806
Autor:
Joy Wang, Deepali Phadke, James E. Dowling, Thomas Engber, Eman Ayyub, Xiaowei Jin, Petter Russell C, Kurt Van Vloten, Jeffrey Vessels, Chang He Xi, Serajul Haque, Gnanasambandam Kumaravel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4809-4813
Potent and selective antagonists of the adenosine A2A receptor often contain a nitrogen-rich fused-ring heterocyclic core. Replacement of the core with an isomeric ring system has previously been shown to improve target affinity, selectivity, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c938546ec38ee5174c45c51f5b3cbef9
https://doi.org/10.1016/j.bmcl.2005.07.052
https://doi.org/10.1016/j.bmcl.2005.07.052
Autor:
G Joseph Franklin, Raksha A. Acharya, Thomas Lohr, J. Larkin, Gary K. O’Donovan, Christopher C. Arico-Muendel, Todd W Shearer, Sibongile Mataruse, John W. Cuozzo, Hongfeng Deng, Paolo A. Centrella, Michael Neeb, Rosalie Matico, Katie L Sargent Bedard, Jeffrey W. Gross, Tiffany Carpenter, Kenneth E Lind, Heather O’Keefe, Kurt van Vloten, Matthew A. Clark, Svetlana L. Belyanskaya, Christopher P. Davie, Monique M Thompson, Steven R. Skinner, Barry A. Morgan
Publikováno v:
Journal of medicinal chemistry. 55(16)
The metalloprotease ADAMTS-5 is considered a potential target for the treatment of osteoarthritis. To identify selective inhibitors of ADAMTS-5, we employed encoded library technology (ELT), which enables affinity selection of small molecule binders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4b41303140a8747b1087159c22ca37
https://pubmed.ncbi.nlm.nih.gov/22891645
https://pubmed.ncbi.nlm.nih.gov/22891645
Autor:
Nils Jakob Vest Hansen, Dennis Benjamin, Jennifer L Svendsen, Christopher P. Davie, Lujia Tang, Matthew C Oliff, G Joseph Franklin, Sibongile Mataruse, John W. Cuozzo, Steffen Phillip Creaser, Paul Myers, Richard W. Wagner, Neil R Carlson, Steven P Hale, Christopher C. Arico-Muendel, Michael Kelley, Steven R. Skinner, Gang Yao, Jeffrey A. Messer, Yun Ding, Christopher S. Kollmann, Svetlana L. Belyanskaya, Malcolm L. Gefter, David I. Israel, Alexander L. Satz, Kurt van Vloten, Cecil E Rise, Cynthia H. Chiu, Kurt D Franzen, Raksha A. Acharya, Heather O’Keefe, Malcolm J. Kavarana, Paolo A. Centrella, Patricia F Medeiros, Barry A. Morgan, Matthew A. Clark, Jinwei Jiang, Kenneth E Lind, Baoguang Zhao, Fan Li
Publikováno v:
Nature Chemical Biology. 5:772-772
Nat. Chem. Biol. 5, 647–654 (2009); published online 2 August 2009; corrected after print 17 September 2009 In the version of this article initially published, the IC50 values in the table in Figure 3c were listed as nM instead of μM. The error ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93f6f79e70e0006f13ecf2759332fbf
https://doi.org/10.1038/nchembio1009-772
https://doi.org/10.1038/nchembio1009-772
Autor:
Clark, Matthew A, Acharya, Raksha A, Arico-Muendel, Christopher C, Belyanskaya, Svetlana L, Benjamin, Dennis R, Carlson, Neil R, Centrella, Paolo A, Chiu, Cynthia H, Creaser, Steffen P, Cuozzo, John W, Davie, Christopher P, Ding, Yun, Franklin, G Joseph, Franzen, Kurt D, Gefter, Malcolm L, Hale, Steven P, Hansen, Nils J V, Israel, David I, Jiang, Jinwei, Kavarana, Malcolm J
Publikováno v:
Nature Chemical Biology. Oct2009, Vol. 5 Issue 10, p772-772. 1p.