Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kurt Spittaels"'
Autor:
Alex S. Genshaft, Sonu Subudhi, Arlin Keo, Juan Diego Sanchez Vasquez, Nádia Conceição-Neto, Deeqa Mahamed, Lauke L. Boeijen, Nadia Alatrakchi, Chris Oetheimer, Mike Vilme, Riley Drake, Ira Fleming, Nancy Tran, Constantine Tzouanas, Jasmin Joseph-Chazan, Martin Arreola Villanueva, Harmen J. G. van de Werken, Gertine W. van Oord, Zwier M.A. Groothuismink, Boris J. Beudeker, Zgjim Osmani, Shirin Nkongolo, Aman Mehrotra, Kurt Spittaels, Jordan Feld, Raymond T. Chung, Robert J. de Knegt, Harry L. A. Janssen, Jeroen Aerssens, Jacques Bollekens, Nir Hacohen, Georg M. Lauer, Andre Boonstra, Alex K. Shalek, Adam J. Gehring
Publikováno v:
Hepatology.
Autor:
Sofie Deleu, Kurt Spittaels, Thomas N. Kakuda, Lorant Leopold, Vera Hillewaert, Jurgen Vercauteren, Amy Lwin, Richard M. W. Hoetelmans
Publikováno v:
British Journal of Clinical Pharmacology. 84:2663-2672
AIMS: The aim of this study was to evaluate the drug–drug interaction between pimodivir, a novel, non‐nucleoside polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A virus polymerase complex, and oseltamivir, to assess the feasib
Autor:
Peter de Boer, Glenn Dumont, Violette Coppens, Stephan Claes, Kurt Spittaels, Manuel Morrens, Jeroen Schuermans, Bernard Sabbe, Peter Niemegeers
Publikováno v:
Journal of affective disorders
Journal of affective disorders, 245, 356-363. Elsevier
Journal of affective disorders, 245, 356-363. Elsevier
Background Major Depressive Disorder (MDD) covers a wide spectrum of symptoms, including cognitive dysfunction, which can persist during remission. Both inflammatory states and psychosocial stress play a role in MDD pathogenesis. Methods The effects
Autor:
James Witek, Goedele De Smedt, Veerle Vyncke, Richard M. W. Hoetelmans, Thomas N. Kakuda, Kurt Spittaels, Monika Schöller-Gyüre, Sophie H. Akuma
Publikováno v:
The Journal of Clinical Pharmacology. 53:202-210
Background A previous study investigating coadministration of etravirine, a nonnucleoside reverse transcriptase inhibitor, and lopinavir/ritonavir soft-gel formulation resulted in nonclinically relevant changes in etravirine and lopinavir exposure. T
Autor:
Bart De Strooper, Kurt Spittaels, Mieke Vanbrabant, Dirk Pollet, Veerle Baekelandt, André Delacourte, Mik Staes, Frea Coun, Adrian Cohen, Amantha Thathiah, Marcel Hoffmann, Katrien Horré, David F. Fischer, Pascal Gerard Merchiers
Publikováno v:
Science. 323:946-951
Deposition of the amyloid-β peptide is a pathological hallmark of Alzheimer's disease. A high-throughput functional genomics screen identified G protein–coupled receptor 3 (GPR3), a constitutively active orphan G protein–coupled receptor, as a m
Autor:
Katrien Horré, Bart De Strooper, Mostafa Bentahir, Numa R. Gottardi-Littell, Omar Nyabi, Wim Annaert, Kurt Spittaels, Pascal Gerard Merchiers, An Herreman, Christine Van Broeckhoven
Publikováno v:
Journal of biological chemistry
The Presenilins are part of the gamma-secretase complex that is involved in the regulated intramembrane proteolysis of amyloid precursor protein and other type I integral membrane proteins. Nicastrin, Pen-2, and Aph1 are the other proteins of this co
Autor:
Hugo Geerts, E. De Feyter, C. Nolten, Rony Nuydens, P. Van Osta, C. Verhulst, Kurt Spittaels, C. Van den Haute, F. Van Leuven, G. Van Den Kieboom
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 1, Pp 38-48 (2002)
Coexpression of constitutively active GSK-3beta[S9A] rescued the axonal pathology induced by overexpression of human tau in transgenic mice (Spittaels et al., (2000) J. Biol. Chem. 275, 41340-41349). We isolated dorsal root ganglion (DRG) neuronal cu
Autor:
Chris Van den Haute, Fred Van Leuven, Ina Tesseur, Ilse Dewachter, Diederik Moechars, Kurt Spittaels, Jo Van Dorpe
Publikováno v:
Scopus-Elsevier
We have reported transgenic mice with neuronal overexpression of the clinical mutant beta-amyloid precursor protein (APP) known as London, which develop an AD-related phenotype [Moechers, Dewachter, Lorent, Reversé, Baekelandt, Nadiu, Tesseur, Spitt
Autor:
Chris Van den Haute, Jo Van Dorpe, Diederik Moechars, Kurt Spittaels, Fred Van Leuven, Ina Tesseur
Publikováno v:
The American Journal of Pathology. 156:951-964
Epidemiological studies have established that the epsilon 4 allele of the ApoE gene (ApoE4) constitutes an important risk factor for Alzheimer’s disease and might influence the outcome of central nervous system injury. The mechanism by which ApoE4
Autor:
Kris Vandezande, Ruth J. F. Loos, Chris Van den Haute, Hugo Geerts, Jo Van Dorpe, Koen Bruynseels, Kurt Spittaels, Isabelle Laenen, Alfons Van Lommel, Marc Mercken, Fred Van Leuven, Raf Sciot
Publikováno v:
The American Journal of Pathology. 155:2153-2165
Mutations in the human tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. Some mutations, including mutations in intron 10, induce increased levels of the functionally normal four-repeat tau protein isoform, leading to n