Výsledky vyhledávání - "Kurt Ritter."

Probing Factor Xa Protein–Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands

Autor: María Isabel Fernández-Bachiller, Songhwan Hwang, María Elena Schembri, Peter Lindemann, Mónica Guberman, Svenja Herziger, Edgar Specker, Hans Matter, David W. Will, Jörg Czech, Michael Wagner, Armin Bauer, Herman Schreuder, Kurt Ritter, Matthias Urmann, Volkmar Wehner, Han Sun, Marc Nazaré

Publikováno v: Journal of Medicinal Chemistry. 65:13013-13028

The accurate prediction of protein-ligand binding affinity belongs to one of the central goals in computer-based drug design. Molecular dynamics (MD)-based free energy calculations have become increasingly popular in this respect due to their accurac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8a1e421784852173ad676bcf5b0524
https://doi.org/10.1021/acs.jmedchem.2c00865

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G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges

Autor: Kurt Ritter, Christoph Pöverlein, Lothar Schwink, Christian Buning, Nis Halland

Publikováno v: Journal of Medicinal Chemistry. 59:3579-3592

In this Perspective, recent advances and challenges in the development of GPR119 agonists as new oral antidiabetic drugs will be discussed. Such agonists are expected to exhibit a low risk to induce hypoglycemia as well as to have a beneficial impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684667b796a03b2f75d9d8ba8cb47dd4
https://doi.org/10.1021/acs.jmedchem.5b01198

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1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes

Autor: Georg Tschank, Christian Engel, Géraldine Farjot, Kurt Ritter, Torsten Haack, Thomas Böhme, Stefan Gussregen

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:4685-4691

Racemic cis-1,1-dioxo-5,6-dihydro-[4,1,2]oxathiazine derivative 4a was isolated as an impurity in a sample of a hit from a HTS campaign on 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). After separation by chiral chromatography the 4a-S, 8a-R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588d8acb0bb0dcee7ae1f95086141680
https://doi.org/10.1016/j.bmcl.2013.05.102

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Evidence for CCl/CBr⋅⋅⋅π Interactions as an Important Contribution to Protein-Ligand Binding Affinity

Autor: Armin Bauer, Volkmar Wehner, Marc Nazaré, Hans Matter, Michael Wagner, Herman Schreuder, Stefan Güssregen, Matthias Urmann, Kurt Ritter, David William Will

Publikováno v: Angewandte Chemie. 121:2955-2960

Attractive chlorine: Noncovalent interactions between chlorine or bromine atoms and aromatic rings in proteins open up a new method for the manipulation of molecular recognition. Substitution at distinct positions of two factor Xa inhibitors improves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608615d472cd80dbb977bcbace2bb626
https://doi.org/10.1002/ange.200806219

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Election 2004 Concession and Victory Speeches

Autor: Jennifer Willyard, Kurt Ritter

Publikováno v: American Behavioral Scientist. 49:488-509

This analysis of the 2004 presidential election concession-victory ritual shows that generic norms had the greatest influence on the speeches, but presidential candidates John Kerry and George W. Bush occasionally violated generic expectations due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7d6f0d3b97c1121b13e6e20cd4d0d10
https://doi.org/10.1177/0002764205279439

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Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography

Autor: Martin Lorenz, Michael Wagner, David William Will, Kurt Ritter, Melanie Essrich, Armin Bauer, Marc Nazaré, Volkmar Wehner, Volker Laux, Matthias Urmann, Hans Matter, Herman Schreuder, Jörg Czech

Publikováno v: Journal of Medicinal Chemistry. 48:4511-4525

Structure-activity relationships within a series of highly potent 2-carboxyindole-based factor Xa inhibitors incorporating a neutral P1 ligand are described with particular emphasis on the structural requirements for addressing subpockets of the fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3dbcfaebcf593e3b05a7c57ad2e78d
https://doi.org/10.1021/jm0490540

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A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection

Autor: Brad McRae, David W. Borhani, Biqin Li, Kurt Ritter, Gavin C. Hirst, David J. Calderwood, Wendy Waegell, Sheldon E. Ratnofsky, Michael Friedman, A.K.W. Leung

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:2613-2616

We have identified the pyrazolo[3,4-d]pyrimidine A-420983 (compound 7) as a potent inhibitor of lck. A-420983 exhibits oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580da66de5527b2d655e007519b924e5
https://doi.org/10.1016/j.bmcl.2004.02.101

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