Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kurt Ritter"'
Autor:
María Isabel Fernández-Bachiller, Songhwan Hwang, María Elena Schembri, Peter Lindemann, Mónica Guberman, Svenja Herziger, Edgar Specker, Hans Matter, David W. Will, Jörg Czech, Michael Wagner, Armin Bauer, Herman Schreuder, Kurt Ritter, Matthias Urmann, Volkmar Wehner, Han Sun, Marc Nazaré
Publikováno v:
Journal of Medicinal Chemistry. 65:13013-13028
The accurate prediction of protein-ligand binding affinity belongs to one of the central goals in computer-based drug design. Molecular dynamics (MD)-based free energy calculations have become increasingly popular in this respect due to their accurac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8a1e421784852173ad676bcf5b0524
https://doi.org/10.1021/acs.jmedchem.2c00865
https://doi.org/10.1021/acs.jmedchem.2c00865
Autor:
Kurt Ritter
Publikováno v:
Ullmann's Encyclopedia of Industrial Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::637c080064dc99956462feb3c9848f92
https://doi.org/10.1002/14356007.a02_313.pub2
https://doi.org/10.1002/14356007.a02_313.pub2
Autor:
Kurt Ritter
Publikováno v:
Ullmann's Encyclopedia of Industrial Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::174f245800c7b4b42cfc29bebccc7adf
https://doi.org/10.1002/14356007.a03_001.pub3
https://doi.org/10.1002/14356007.a03_001.pub3
Publikováno v:
Journal of Medicinal Chemistry. 59:3579-3592
In this Perspective, recent advances and challenges in the development of GPR119 agonists as new oral antidiabetic drugs will be discussed. Such agonists are expected to exhibit a low risk to induce hypoglycemia as well as to have a beneficial impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684667b796a03b2f75d9d8ba8cb47dd4
https://doi.org/10.1021/acs.jmedchem.5b01198
https://doi.org/10.1021/acs.jmedchem.5b01198
Autor:
Georg Tschank, Christian Engel, Géraldine Farjot, Kurt Ritter, Torsten Haack, Thomas Böhme, Stefan Gussregen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4685-4691
Racemic cis-1,1-dioxo-5,6-dihydro-[4,1,2]oxathiazine derivative 4a was isolated as an impurity in a sample of a hit from a HTS campaign on 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). After separation by chiral chromatography the 4a-S, 8a-R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588d8acb0bb0dcee7ae1f95086141680
https://doi.org/10.1016/j.bmcl.2013.05.102
https://doi.org/10.1016/j.bmcl.2013.05.102
Autor:
Armin Bauer, Volkmar Wehner, Marc Nazaré, Hans Matter, Michael Wagner, Herman Schreuder, Stefan Güssregen, Matthias Urmann, Kurt Ritter, David William Will
Publikováno v:
Angewandte Chemie. 121:2955-2960
Attractive chlorine: Noncovalent interactions between chlorine or bromine atoms and aromatic rings in proteins open up a new method for the manipulation of molecular recognition. Substitution at distinct positions of two factor Xa inhibitors improves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608615d472cd80dbb977bcbace2bb626
https://doi.org/10.1002/ange.200806219
https://doi.org/10.1002/ange.200806219
Autor:
Jennifer Willyard, Kurt Ritter
Publikováno v:
American Behavioral Scientist. 49:488-509
This analysis of the 2004 presidential election concession-victory ritual shows that generic norms had the greatest influence on the speeches, but presidential candidates John Kerry and George W. Bush occasionally violated generic expectations due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7d6f0d3b97c1121b13e6e20cd4d0d10
https://doi.org/10.1177/0002764205279439
https://doi.org/10.1177/0002764205279439
Autor:
Martin Lorenz, Michael Wagner, David William Will, Kurt Ritter, Melanie Essrich, Armin Bauer, Marc Nazaré, Volkmar Wehner, Volker Laux, Matthias Urmann, Hans Matter, Herman Schreuder, Jörg Czech
Publikováno v:
Journal of Medicinal Chemistry. 48:4511-4525
Structure-activity relationships within a series of highly potent 2-carboxyindole-based factor Xa inhibitors incorporating a neutral P1 ligand are described with particular emphasis on the structural requirements for addressing subpockets of the fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3dbcfaebcf593e3b05a7c57ad2e78d
https://doi.org/10.1021/jm0490540
https://doi.org/10.1021/jm0490540
Autor:
Brad McRae, David W. Borhani, Biqin Li, Kurt Ritter, Gavin C. Hirst, David J. Calderwood, Wendy Waegell, Sheldon E. Ratnofsky, Michael Friedman, A.K.W. Leung
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2613-2616
We have identified the pyrazolo[3,4-d]pyrimidine A-420983 (compound 7) as a potent inhibitor of lck. A-420983 exhibits oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580da66de5527b2d655e007519b924e5
https://doi.org/10.1016/j.bmcl.2004.02.101
https://doi.org/10.1016/j.bmcl.2004.02.101
Autor:
Andrew Burchat, Michael M. Friedman, David J. Calderwood, Barbara S. Skinner, Kurt Ritter, Gavin C. Hirst, Biqin Li, Paul Rafferty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1687-1690
A series of para-substituted 3-phenyl pyrazolopyrimidines was synthesized and evaluated as inhibitors of lck. The nature of the substitution affected enzyme selectivity and potency for lck, src, kdr, and tie-2. The para-phenoxyphenyl analogue 2 is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c10e361ba0df8c865068a299faab12
https://doi.org/10.1016/s0960-894x(02)00196-8
https://doi.org/10.1016/s0960-894x(02)00196-8