Protein Toxins as Antibody–Drug Conjugate (ADC) Payloads

Autor: Kurt R. Gehlsen

Publikováno v: Cytotoxic Payloads for Antibody – Drug Conjugates ISBN: 9781788010771

Targeted therapeutics such as antibody–drug conjugates and immunotoxins represent a new era of therapeutic intervention aimed at improving patient outcomes by reducing off-target toxicities and increasing drug concentrations at the intended disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::351abf8ca72172f1403f7ed3c8eda5ad
https://doi.org/10.1039/9781788012898-00427

A deimmunised form of the ribotoxin, α-sarcin, lacking CD4+ T cell epitopes and its use as an immunotoxin warhead

Autor: Tim Jones, Matthew P. Baker, Francis J. Carr, Mark H. Fogg, Robert George Edward Holgate, Arron Hearn, Javier Lacadena, Kurt R. Gehlsen, Dorota Kozub

Publikováno v: E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Protein Engineering, Design and Selection
E-Prints Complutense. Archivo Institucional de la UCM
instname

Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209fe0a1eed852bfde9eaf83aad40f8f

The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach

Autor: Jared Kuemmerle, Shannon P. Archer, John Drewe, Kurt R. Gehlsen, Regina Brand, Ben Tseng, Jean Yu Wang, Han-Zhong Zhang, Katayoun Jessen, Sui Xiong Cai, Ling Qiu, Nicole M. English, Sergei Maliartchouk, Shailaja Kasibhatla

Publikováno v: Molecular Cancer Therapeutics. 4:761-771

A novel series of 3,5-diaryl-oxadiazoles was identified as apoptosis-inducing agents through our cell and chemical genetics–based screening assay for compounds that induce apoptosis using a chemical genetics approach. Several analogues from this se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd217a460908e19801815863c1258e93
https://doi.org/10.1158/1535-7163.mct-04-0333

Treatment with histamine dihydrochloride and interleukin-2 in patients with advanced metastatic malignant melanoma

Autor: Sanjiv S. Agarwala, Steven J. O'Day, Kurt R. Gehlsen, John A. Glaspy, Peter Naredi, Carrie L Kass

Publikováno v: Melanoma Research. 13:307-311

Intravenous high dose bolus therapy with interleukin-2 (IL2) is associated with low overall response rates (15%) and significant toxicity. Phase II and III trials of a lower dose subcutaneous regimen of IL2 administered alone (n = 152) or in combinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbc08b41dbbc14c049b5d8da99ff4a5
https://doi.org/10.1097/00008390-200306000-00014

Results From a Randomized Phase III Study Comparing Combined Treatment With Histamine Dihydrochloride Plus Interleukin-2 Versus Interleukin-2 Alone in Patients With Metastatic Melanoma

Autor: Sanjiv S. Agarwala, John Glaspy, Steven J. O’Day, Malcolm Mitchell, John Gutheil, Eric Whitman, Rene Gonzalez, Evan Hersh, Lynn Feun, Robert Belt, Frank Meyskens, Kristoffer Hellstrand, Diana Wood, John M. Kirkwood, Kurt R. Gehlsen, Peter Naredi

Publikováno v: Journal of Clinical Oncology. 20:125-133

PURPOSE: Reactive oxidative species (ROS) produced by phagocytic cells have been ascribed a role in the localized suppression of lymphocyte function within malignant tumors. Histamine has been shown to inhibit ROS formation and possibly synergize wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39de8012ca17524036653d6a2bc5d7e5
https://doi.org/10.1200/jco.2002.20.1.125