Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Kurt R, Stenmark"'
Autor:
Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Kevin Nolan, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. Graham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSchistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal rol
Externí odkaz:
https://doaj.org/article/c4fa6ee4bd3349f19baf5bada146c57a
Autor:
Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. Stenmark
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHypoxia is a common pathological driver contributing to various forms of pulmonary vascular diseases leading to pulmonary hypertension (PH). Pulmonary interstitial macrophages (IMs) play pivotal roles in immune and vascular dysfunction, l
Externí odkaz:
https://doaj.org/article/ff6beb390653433dbe01318df19ac657
Publikováno v:
Cells, Vol 13, Iss 11, p 914 (2024)
Fibroblasts, among the most prevalent and widely distributed cell types in the human body, play a crucial role in defining tissue structure. They do this by depositing and remodeling extracellular matrixes and organizing functional tissue networks, w
Externí odkaz:
https://doaj.org/article/f42137f92d2d499881f96f693dafce79
Autor:
Kiruphagaran Thangaraju PhD, Saini Setua PhD, Christina Lisk PhD, Delaney Swindle MS, Daniel Stephenson PhD, Monika Dzieciatkowska PhD, Derek R. Lamb BS, Parikshit Moitra PhD, David Pak MS, Kathryn Hassell MD, Gemlyn George MD, Rachelle Nuss MD, Pavel Davizon-Castillo MD, Kurt R. Stenmark MD, Angelo D’Alessandro PhD, David C. Irwin PhD, Paul W. Buehler PharmD, PhD
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis, Vol 29 (2023)
Aberrant coagulation in sickle cell disease (SCD) is linked to extracellular vesicle (EV) exposure. However, there is no consensus on the contributions of small EVs (SEVs) and large EVs (LEVs) toward underlying coagulopathy or on their molecular carg
Externí odkaz:
https://doaj.org/article/4769d021364e45e397107d74814a04a5
Autor:
Lydie Plecitá-Hlavatá, Andrea Brázdová, Monika Křivonosková, Cheng-Jun Hu, Tzu Phang, Jan Tauber, Min Li, Hui Zhang, Konrad Hoetzenecker, Slaven Crnkovic, Grazyna Kwapiszewska, Kurt R. Stenmark
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIn pulmonary hypertension (PH), pulmonary arterial remodeling is often accompanied by perivascular inflammation. The inflammation is characterized by the accumulation of activated macrophages and lymphocytes within the adventitial stroma,
Externí odkaz:
https://doaj.org/article/1b0559c1faa0478e9a15680b503aa81a
Autor:
Vitaly O. Kheyfets, Andrew J. Sweatt, Mardi Gomberg-Maitland, Dunbar D. Ivy, Robin Condliffe, David G. Kiely, Allan Lawrie, Bradley A. Maron, Roham T. Zamanian, Kurt R. Stenmark
Publikováno v:
ERJ Open Research, Vol 9, Iss 1 (2023)
Background Pulmonary arterial hypertension (PAH) is a heterogeneous and complex pulmonary vascular disease associated with substantial morbidity. Machine-learning algorithms (used in many PAH risk calculators) can combine established parameters with
Externí odkaz:
https://doaj.org/article/0f45d5cc732d4dd089f3f50bc3a69539
Autor:
Vijaya Karoor, Delaney Swindle, David I Pak, Julie Harral, Derek Strassheim, Mehdi A Fini, Edward Dempsey, Kurt R Stenmark, Kathryn Hassell, Rachelle Nuss, Paul W. Buehler, David C. Irwin
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-11 (2021)
Macrophages are a heterogeneous population with both pro‐ and anti‐inflammatory functions play an essential role in maintaining tissue homeostasis, promoting inflammation under pathological conditions, and tissue repair after injury. In pulmonary
Externí odkaz:
https://doaj.org/article/120e16e92c14421486d903082b393f81
Autor:
Mehdi A. Fini, Miguel A. Lanaspa, Eric A. Gaucher, Brian Boutwell, Takahiko Nakagawa, Richard M. Wright, Laura G. Sanchez-Lozada, Peter Andrews, Kurt R. Stenmark, Richard J. Johnson
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-5 (2021)
Abstract Background Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to cause oxidative stress to mitochondria and to
Externí odkaz:
https://doaj.org/article/6cf8865c41f7429f8e6c8c278ac69c75
Autor:
Sue Gu, Claudia Mickael, Rahul Kumar, Michael H. Lee, Linda Sanders, Biruk Kassa, Julie Harral, Jason Williams, Kirk C. Hansen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Right ventricular (RV) failure is the primary cause of death in pulmonary hypertension (PH), but the mechanisms of RV failure are not well understood. We hypothesized macrophages in the RV contribute to the RV response in PH. We induced PH i
Externí odkaz:
https://doaj.org/article/783929df348a4cba9dd4c63c25ba23b0
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102271- (2022)
Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and the metabolic syndrome and appears to contribute to the renal, cardiovascular and pulmonary comorbidities that are associated with these disorders. Most p
Externí odkaz:
https://doaj.org/article/e48918b337fa419d864bed66d7dedcf4