Výsledky vyhledávání - "Kurt Prof Dr Klemm"

Characterization of the Dexniguldipine Binding Site in the Multidrug Resistance-Related Transport Protein P-Glycoprotein by Photoaffinity Labeling and Mass Spectrometry

Autor: Michael Przybylski, Thomas Denzinger, Kurt Prof Dr Klemm, S. Haas, W Ise, Volker Gekeler, Volker Dr Figala, Wolf-Rüdiger Ulrich, C Borchers, Rainer Boer

Publikováno v: Molecular Pharmacology. 61:1366-1376

Human P-glycoprotein (P-gp), an integral membrane transport protein, is responsible for the efflux of various drugs, including cytostatics from cancer cells leading to multidrug resistance. P-gp is composed of two homologous half domains, each carryi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d8db5c4a7374094d3fb410752de8cc
https://doi.org/10.1124/mol.61.6.1366

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Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance

Autor: I. Utz, Kurt Prof Dr Klemm, C. Schachtele, Florian Überall, Volker Gekeler, Rainer Boer, Johann Hofmann, W Ise, C Schubert, H. Grunicke, K.H. Sanders

Publikováno v: British Journal of Cancer

Inhibition of protein kinase C (PKC) is discussed as a new approach for overcoming multidrug resistance (MDR) in cancer chemotherapy. For evaluation of this concept we applied the bisindolylmaleimide GF 109203X, which shows a highly selective inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8869fdbf4f5de792bb23c285f53518
https://doi.org/10.1038/bjc.1996.454

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Primary structure differences of human surfactant-associated proteins isolated from normal and proteinosis lung

Autor: Ewald Hannappel, Klaus P. Schäfer, Tilman Voss, Kurt Prof Dr Klemm, Andrea Schäfer, Per F. Nielsen, Jörg Maaßen, Bernhard Landis, Michael Przybylski, Claudia S. Maier

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1138:261-267

The primary structures of human pulmonary surfactant-associated proteins SP-A, SP-B and SP-C isolated from lung lavage of patients with alveolar proteinosis exhibit significant differences from lung surfactant proteins isolated from lungs of healthy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10708a9abc9e882a82d17f0f4d79f303
https://doi.org/10.1016/0925-4439(92)90002-5

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Photoaffinity labelling with a photoreactive analogue of dexniguldipine-HCl (B8509-035) and mass spectrometric structural characterization of the multidrug resistance-related P-glycoprotein

Autor: Michael Przybylski, J Conrad, C Borchers, W. R. Ulrich, Rainer Boer, Volker Gekeler, Kurt Prof Dr Klemm, W. Ise

Publikováno v: Peptides 1994 ISBN: 9789072199218
Peptides 1994

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0582e10c9a68c92178255c2a4cd9380
https://doi.org/10.1007/978-94-011-1468-4_369

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Effects of the selective bisindolylmaleimide PKC inhibitor GF109203X on P-gp and non-P-gp mediated MDR and the proliferation of various tumor cell lines

Autor: Florian Überall, Kurt Prof Dr Klemm, H. Grunicke, W Ise, K.H. Sanders, Johann Hofmann, Volker Gekeler, C Schubert, Rainer Boer

Publikováno v: Anti-Cancer Drugs. 5:28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46354fc77ee757f4515bda945f9290b3
https://doi.org/10.1097/00001813-199409001-00063

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