Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Kurt L, Krause"'
Publikováno v:
PeerJ, Vol 11, p e14969 (2023)
Ribosome-targeting antibiotics comprise over half of antibiotics used in medicine, but our fundamental knowledge of their binding sites is derived primarily from ribosome structures of non-pathogenic species. These include Thermus thermophilus, Deino
Externí odkaz:
https://doaj.org/article/0883e7ddfb124f4fab25a89885e0f905
Autor:
Alice-Roza Eruera, Alice M. McSweeney, Geena M. McKenzie-Goldsmith, Helen K. Opel-Reading, Simone X. Thomas, Ashley C. Campbell, Louise Stubbing, Andrew Siow, Jonathan G. Hubert, Margaret A. Brimble, Vernon K. Ward, Kurt L. Krause
Publikováno v:
Viruses, Vol 15, Iss 11, p 2202 (2023)
Norovirus is the leading cause of viral gastroenteritis worldwide, and there are no approved vaccines or therapeutic treatments for chronic or severe norovirus infections. The structural characterisation of the norovirus protease and drug development
Externí odkaz:
https://doaj.org/article/86ca3c78c4f045989589594a543e6b57
Autor:
Schara Safarian, Helen K. Opel-Reading, Di Wu, Ahmad R. Mehdipour, Kiel Hards, Liam K. Harold, Melanie Radloff, Ian Stewart, Sonja Welsch, Gerhard Hummer, Gregory M. Cook, Kurt L. Krause, Hartmut Michel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
M. tuberculosis cytochrome bd oxidase is of interest as a TB drug target. Here, the authors present the 2.5 Å cryo-EM structure of M. tuberculosis cytochrome bd oxidase and identify a disulfide bond within the canonical quinol binding and oxidation
Externí odkaz:
https://doaj.org/article/d59d3dd24560451195a1764a95c9ea6d
Autor:
Fareeda M. Barzak, Timothy M. Ryan, Nazanin Mohammadzadeh, Stefan Harjes, Maksim V. Kvach, Harikrishnan M. Kurup, Kurt L. Krause, Linda Chelico, Vyacheslav V. Filichev, Elena Harjes, Geoffrey B. Jameson
Publikováno v:
Viruses, Vol 14, Iss 9, p 1974 (2022)
APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain protein that restricts HIV. Altho
Externí odkaz:
https://doaj.org/article/e6bb7a035b1541ab907a372338d6e150
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract The New Zealand glowworm, Arachnocampa luminosa, is well-known for displays of blue-green bioluminescence, but details of its bioluminescent chemistry have been elusive. The glowworm is evolutionarily distant from other bioluminescent creatu
Externí odkaz:
https://doaj.org/article/73316233e598476b9887141e89c27fef
Publikováno v:
Viruses, Vol 13, Iss 10, p 1893 (2021)
Influenza virus is a highly contagious virus that causes significant human mortality and morbidity annually. The most effective drugs for treating influenza are the neuraminidase inhibitors, but resistance to these inhibitors has emerged, and additio
Externí odkaz:
https://doaj.org/article/bf364fc05993415b84fbc0e685dc5f1d
Publikováno v:
Viruses, Vol 13, Iss 10, p 1911 (2021)
At the end of 2019 a newly emerged betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of an outbreak of severe pneumonia, subsequently termed COVID-19, in a number of patients in Wuhan, China. S
Externí odkaz:
https://doaj.org/article/f077a27e4bd347e9ab4a7a44d4286291
Autor:
Aggie, Lawer, Chelsea, Tyler, Kiel, Hards, Laura M, Keighley, Chen-Yi, Cheung, Fabian, Kierek, Simon, Su, Siddharth S, Matikonda, Tyler, McInnes, Joel D A, Tyndall, Kurt L, Krause, Gregory M, Cook, Allan B, Gamble
Publikováno v:
ACS medicinal chemistry letters. 13(10)
A revised total synthesis of aurachin D (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f774d80355356f787d2c75bad92f6c90
https://pubmed.ncbi.nlm.nih.gov/36262396
https://pubmed.ncbi.nlm.nih.gov/36262396
Autor:
Andrew P. Cording, Guillaume Lessene, Rebekah L. Bower, Ian D. Billinghurst, Emma M. Barnes, Bill C. Hawkins, Michael P. Badart, Veera V. Shivaji R. Edupuganti, Kurt L. Krause, Rhonda J. Rosengren, Zohaib Rana, Abigail R. Bland, Helen K. Opel Reading, Gregory M. Cook, Selena C. L. Gilmer, John C. Ashton, Allan B. Gamble, Scott A. Ferguson
Publikováno v:
ChemMedChem. 16:1308-1315
A second-generation enantiospecific synthesis of spiroleucettadine is described. The original reported antibacterial activity was not observed when the experiment was repeated on the synthetic samples; however, significant anti-proliferative activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e503d1e32e0d748f03355cf4ff99b9
https://doi.org/10.1002/cmdc.202000954
https://doi.org/10.1002/cmdc.202000954
Autor:
Reza Khayat, Bryant Avila, Barbara E. Murray, Eileen L Murphy, Gerwald Jogl, Kurt L. Krause, Steven T. Gregory, Torsten Kleffmann, Kavindra V. Singh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Enterococcus faecalis is a gram-positive organism responsible for serious infections in humans, but as with many bacterial pathogens, resistance has rendered a number of commonly used antibiotics ineffective. Here, we report the cryo-EM structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7260f77dfb0ef3fcc6620d99fe625f
http://link.springer.com/article/10.1038/s41598-020-73199-6
http://link.springer.com/article/10.1038/s41598-020-73199-6