Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Kurt J. Doege"'
1
Osteoarthritis of the Hands, Hips and Knees in an Australian Twin Sample — Evidence of Association with the Aggrecan VNTR Polymorphism
Autor: Katherine M. Kirk, Kurt J. Doege, Jacqueline Hecht, Nicholas Bellamy, Nicholas G. Martin
Publikováno v: Twin Research. 6:62-66
Age-related changes in the composition of the cartilage matrix may be associated with the development of osteoarthritis, a relatively late-onset disease characterised by the destruction of joint cartilage. In order to investigate whether differences
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a447327823bb5f26486fa6ae7b7dede9
https://doi.org/10.1375/twin.6.1.62
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2
Alternative Exon Splicing within the Amino-terminal Nontriple-helical Domain of the Rat Pro-α1(XI) Collagen Chain Generates Multiple Forms of the mRNA Transcript Which Exhibit Tissue-dependent Variation
Autor: Kurt J. Doege, Nicholas P. Morris, Julia Thom Oxford
Publikováno v: Journal of Biological Chemistry. 270:9478-9485
Type XI collagen is an integral, although minor component of cartilage collagen fibrils. We have established that alternative exon usage is a mechanism for increasing structural diversity within the amino-terminal nontriple helical domain of the pro-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246fda4b8153b6638929d85ff716f67c
https://doi.org/10.1074/jbc.270.16.9478
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3
Characterization of Type II and Type XI Collagen Synthesis by an Immortalized Rat Chondrocyte Cell Line (IRC) Having a Low Level of Type II Collagen mRNA Expression
Autor: Julia Thom Oxford, Nicholas P. Morris, Walter E. Horton, Kurt J. Doege
Publikováno v: Experimental Cell Research. 213:28-36
The biosynthesis of type XI and type II collagens was examined using a stable rat chondrocyte cell line established by W. E. Horton et al. (1988, Exp. Cell Res. 178, 457-468.). These cells (IRC; immortalized rat chondrocytes) were created by transfor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8706fa4ef957d4bd4a35cd2eddb8a6e
https://doi.org/10.1006/excr.1994.1169
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4
Complete Coding Sequence, Deduced Primary Structure, Chromosomal Localization, and Structural Analysis of Murine Aggrecan
Autor: Peter Horvath, Peter Erhardt, Ferenc Deák, Kurt J. Doege, Silvija N. Coulter, Csaba Fülöp, Erzsébet Walcz, Tibor T. Glant
Publikováno v: Genomics. 22:364-371
We have isolated and sequenced overlapping cDNA clones encoding the entire core protein of aggrecan (the large aggregating chondroitin sulfate/keratan sulfate proteoglycan of cartilage) from three chondrocyte cDNA libraries of BALB/c mice and localiz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e3fe7eb52037bd1ba5290a6bb5fd15
https://doi.org/10.1006/geno.1994.1396
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5
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms
Autor: Y Yamada, T Kimura, Kurt J. Doege, M Sasaki
Publikováno v: Journal of Biological Chemistry. 266:894-902
We have obtained the complete coding sequence of the large aggregating chondroitin sulfate proteoglycan of human cartilage (aggrecan) from a combination of cDNA and genomic exon sequencing. We screened a human costal chondrocyte cDNA library, using r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::feb18a4e96632a0037f88e74325b2dd4
https://doi.org/10.1016/s0021-9258(17)35257-2
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6
Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase
Autor: Francesca A. Mercuri, Kurt J. Doege, Elizabeth C. Arner, Michael A. Pratta, Karena Last, Amanda J. Fosang
Publikováno v: The Journal of biological chemistry. 274(45)
A recombinant human aggrecan G1-G2 fragment comprising amino acids Val(1)-Arg(656) has been expressed in Sf21 cells using a baculovirus expression system. The recombinant G1-G2 (rG1-G2) was purified to homogeneity by hyaluronan-Sepharose affinity chr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1116e05812e6d0a8bf2212d75a69bd23
https://pubmed.ncbi.nlm.nih.gov/10542281
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7
Assignment of the human aggrecan gene (AGC1) to 15q26 using fluorescence in situ hybridization analysis
Autor: Julie R. Korenberg, Judy Grover, Kurt J. Doege, Peter J. Roughley, Xiao N. Chen
Publikováno v: Genomics. 16(2)
The large aggregating proteoglycan aggrecan is a major structural component of the extracellular matrix of articular cartilage. Recent cDNA cloning of the human aggrecan gene (AGC1) reveals a core protein of at least 2316 amino acids characterized by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0f8d317a3eaab1d9e62d3e9dafbfb6
https://pubmed.ncbi.nlm.nih.gov/8314595
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9
Biosynthesis of collagen
Autor: John H. Fessler, K G Duncan, Kurt J. Doege, Liselotte I. Fessler
Publikováno v: Journal of cellular biochemistry. 28(1)
During the biosynthesis and assembly of collagen structures, disulfide links can serve several functions. During biosynthesis they successively stabilize intra-peptide folding and associations of three chains into one molecule. Studies on the refoldi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfef9eb239cdf731b1d728d70186234
https://pubmed.ncbi.nlm.nih.gov/4030901
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