Výsledky vyhledávání - "Kurt J Varner"

Akademický článek

Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy.

Autor: Yumei Feng, Chetan Hans, Elizabeth McIlwain, Kurt J Varner, Eric Lazartigues

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48910 (2012)

Angiotensin-converting enzyme type 2 (ACE2) has been shown to be an important member of the renin angiotensin system. Previously, we observed that central ACE2 reduces the development of hypertension following chronic angiotensin II (Ang-II) infusion

Externí odkaz: https://doaj.org/article/f80886bd6a124157a70bf2e0ed6229b3

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Akademický článek

Mesenteric resistance arteries in type 2 diabetic db/db mice undergo outward remodeling.

Autor: Flavia M Souza-Smith, Paige S Katz, Aaron J Trask, James A Stewart, Kevin C Lord, Kurt J Varner, Dalton V Vassallo, Pamela A Lucchesi

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23337 (2011)

Resistance vessel remodeling is controlled by myriad of hemodynamic and neurohormonal factors. This study characterized structural and molecular remodeling in mesenteric resistance arteries (MRAs) in diabetic (db/db) and control (Db/db) mice.Structur

Externí odkaz: https://doaj.org/article/327f705fce144702b8555b3c04ed2c40

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Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function

Autor: Kelsey P. Legendre, Tammy R. Dugas, Alexandra Noël, Kurt J. Varner, Yi-Fan Chen, Daniel B. Paulsen, Merilyn H. Jennings, Balamurugan Subramanian, Arthur L. Penn, Ashlyn C. Harmon, Zakia Perveen

Publikováno v: Am J Physiol Heart Circ Physiol

Airborne particulate matter (PM) is associated with an increased risk for cardiovascular diseases. Although the goal of thermal remediation is to eliminate organic wastes through combustion, when incomplete combustion occurs, organics chemisorb to tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259490afc7de4404efbec21cd0f59941
https://doi.org/10.1152/ajpheart.00725.2020

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Active and Passive Immunization with an Anti-Methamphetamine Vaccine Attenuates the Behavioral and Cardiovascular Effects of Methamphetamine

Autor: Colin N, Haile, Kurt J, Varner, Xia, Huijing, Reetakshi, Arora, Frank M, Orson, Thomas R, Kosten, Therese A, Kosten

Publikováno v: Vaccines; Volume 10; Issue 9; Pages: 1508

Background: Methamphetamine use disorder (MUD) is a growing health concern with no FDA-approved treatment. The present series of studies build upon our previous work developing an anti-methamphetamine (MA) vaccine for MUD. We determined the effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f8e919d6ad3635ec0355f5ba1f9454

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Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations

Autor: Félix Carvalho, Fernando Remião, José Luís Dores-Sousa, M. Gabriela Almeida, Rui A. Carvalho, Rute P. Eleutério, Patricia Rodrigues, Vera Marisa Costa, João Paulo Capela, Maria de Lourdes Bastos, José Alberto Duarte, Joana R. Sousa, Kurt J. Varner

Publikováno v: Archives of Toxicology. 94:4067-4084

Mitoxantrone (MTX) is used to treat several types of cancers and to improve neurological disability in multiple sclerosis. Unfortunately, cardiotoxicity is a severe and common adverse effect in MTX-treated patients. Herein, we aimed to study early an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47475838f38f043509cdeb4179ec24ca
https://doi.org/10.1007/s00204-020-02874-4

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Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations

Autor: Vera Marisa, Costa, João Paulo, Capela, Joana R, Sousa, Rute P, Eleutério, Patrícia R S, Rodrigues, José Luís, Dores-Sousa, Rui A, Carvalho, Maria, Lourdes Bastos, José Alberto, Duarte, Fernando, Remião, M Gabriela, Almeida, Kurt J, Varner, Félix, Carvalho

Publikováno v: Archives of toxicology. 94(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ad5d71bb1e69a8e057817c4f14c44ef
https://pubmed.ncbi.nlm.nih.gov/32894303

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Comprehensive review of cardiovascular toxicity of drugs and related agents

Autor: Marie Vopršalová, Luděk Jahodář, Jana Karlíčková, Jiří Patočka, Cardiotox Hradec Králové Researchers, Přemysl Mladěnka, Tox-Oer, Fernando Remião, Aleš Mladěnka, Lenka Applová, Jana Pourová, Martin Štěrba, Vera Marisa Costa, Kurt J. Varner

Publikováno v: Medicinal Research Reviews

Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496b194b5e321a0c8d18132c6bc8af74
https://doi.org/10.1002/med.21476

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Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney

Autor: Juan Gao, David J. Lefer, Frank W. Smart, David J. Polhemus, Amy Scarborough, Rishi K. Trivedi, Traci T. Goodchild, Daniel R. Kapusta, Kurt J. Varner, Zhen Li, Huijing Xia

Publikováno v: Journal of the American College of Cardiology. 70:2139-2153

Background Sustained sympathetic activation contributes to the progression of myocardial cell injury, cardiac fibrosis, and left ventricular (LV) dysfunction in heart failure (HF). Objectives This study investigated the effects of radiofrequency rena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771212a713875902032f471b01cb8373
https://doi.org/10.1016/j.jacc.2017.08.056

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