Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kurt Hoogewijs"'
Autor:
Andrew M. James, Kurt Hoogewijs, Angela Logan, Andrew R. Hall, Shujing Ding, Ian M. Fearnley, Michael P. Murphy
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2105-2112 (2017)
Summary: Acetyl coenzyme A (AcCoA), a key intermediate in mitochondrial metabolism, N-acetylates lysine residues, disrupting and, in some cases, regulating protein function. The mitochondrial lysine deacetylase Sirtuin 3 (Sirt3) reverses this modific
Externí odkaz:
https://doaj.org/article/fd9888f6e25e4dfb9bb330d5437d5477
Autor:
Michael A. McCoy, Dominique Spicer, Neil Wells, Kurt Hoogewijs, Marc Fiedler, Matthias G. J. Baud
Publikováno v:
Journal of Medicinal Chemistry. 65:7246-7261
The canonical Wingless-related integration site signaling pathway plays a critical role in human physiology, and its dysregulation can lead to an array of diseases. β-Catenin is a multifunctional protein within this pathway and an attractive yet cha
Autor:
Laia Miret-Casals, Willem Vannecke, Kurt Hoogewijs, Gianluca Arauz-Garofalo, Marina Gay, Mireia Díaz-Lobo, Marta Vilaseca, Christophe Ampe, Marleen Van Troys, Annemieke Madder
Publikováno v:
Chemical Communications. 57:6054-6057
We describe furan as a triggerable 'warhead' for site-specific cross-linking using the actin and thymosin β4 (Tβ4)-complex as model of a weak and dynamic protein-protein interaction (PPI) with known 3D structure and with application potential in di
Autor:
Joris Jourquin, Lucas Alves Neubus Claus, Brenda A. Peterson, Nick Vangheluwe, Kurt Hoogewijs, Davy Opdenacker, Tom Beeckman, Qiaozhi Yu, Annemieke Madder, Andrzej Drozdzecki, Zachary L. Nimchuk, Boris Parizot, Ana Fernandez, Eugenia Russinova, Stefania Morales-Herrera, Hugues De Gernier, Takanori Maruta, Ke Xu, Willem Vannecke
Publikováno v:
Nature Plants. 6:533-543
During lateral root initiation, lateral root founder cells undergo asymmetric cell divisions that generate daughter cells with different sizes and fates, a prerequisite for correct primordium organogenesis. An excess of the GLV6/RGF8 peptide disrupts
Autor:
Richard C. Hartley, Marta Loureiro-López, Shujing Ding, Sabine Arndt, Michael P. Murphy, John F. Mulvey, Nils Burger, Abigail A.I. Norman, Kurt Hoogewijs, Olga Sauchanka, Andrew M. James, Ian M. Fearnley, Thomas Krieg, Amin Mottahedin
Publikováno v:
Cell chemical biology. 29(4)
Mammalian complex I can adopt catalytically active (A-) or deactive (D-) states. A defining feature of the reversible transition between these two defined states is thought to be exposure of the ND3 subunit Cys39 residue in the D-state and its occlus
Autor:
Xinxin Zuo, Michael P. Murphy, Kuanxing Gao, Man Cheng, Xiaorong Zhang, Kurt Hoogewijs, Xiang-Dong Fu, Jinzhong Lin
Publikováno v:
Cell Res
RNA interference (RNAi) has been thought to be a gene-silencing pathway present in most eukaryotic cells to safeguard the genome against retrotransposition. Small interfering RNAs (siRNAs) have also become a powerful tool for studying gene functions.
Autor:
Kurt Hoogewijs, Andrew M. James, Ian M. Fearnley, Andrew R. Hall, Angela Logan, Shujing Ding, Michael P. Murphy
Publikováno v:
Cell Reports
Cell Reports, Vol 18, Iss 9, Pp 2105-2112 (2017)
Cell Reports, Vol 18, Iss 9, Pp 2105-2112 (2017)
Summary Acetyl coenzyme A (AcCoA), a key intermediate in mitochondrial metabolism, N-acetylates lysine residues, disrupting and, in some cases, regulating protein function. The mitochondrial lysine deacetylase Sirtuin 3 (Sirt3) reverses this modifica
Autor:
Kurt Hoogewijs, Michael J. Gait, Michael P. Murphy, Andrew M. James, Robert N. Lightowlers, Robin A.J. Smith
Publikováno v:
Chembiochem
Mitochondria are central to health and disease, hence there is considerable interest in developing mitochondria‐targeted therapies that require the delivery of peptides or nucleic acid oligomers. However, progress has been impeded by the lack of a
Mitochondria are best known for their ability to provide energy in the form of an elevated ATP/ADP ratio to the cell via oxidative phosphorylation and, impairment of mitochondrial ATP production can lead to a variety of diseases. For many of these di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7570fd5aa9c1f1feb572e4359d5a37e9
Autor:
Kurt Hoogewijs, Andrew M. James, Michael P. Murphy, Anthony C. Smith, Cassandra L. Smith, Alan J. Robinson
Publikováno v:
Trends in biochemical sciences. 43(11)
Thousands of protein acyl modification sites have now been identified in vivo. However, at most sites the acylation stoichiometry is low, making functional enzyme-driven regulation in the majority of cases unlikely. As unmediated acylation can occur