Výsledky vyhledávání - "Kurt Heinz Bauer"

Steam sterilisation of vesicular phospholipid gels

Autor: Martin Brandl, Kurt-Heinz Bauer, Christine Tardi, Markus Drechsler

Publikováno v: International Journal of Pharmaceutics. 217:161-172

Vesicular phospholipid gels (VPGs), highly concentrated phospholipid dispersions of semisolid consistency and vesicular morphology are under investigation as potential implantable depots for sustained release of drugs and as intermediates for subsequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032fbf62aae646151e395b6719d094b2
https://doi.org/10.1016/s0378-5173(01)00605-6

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Preparation and characterization of semi-solid phospholipid dispersions and dilutions thereof

Autor: Markus Drechsler, Kurt-Heinz Bauer, Martin Brandl, Margret Schmidtgen, Christine Tardi, Dieter Bachmann

Publikováno v: International Journal of Pharmaceutics. 170:187-199

Highly concentrated, viscous to semi-solid phospholipid dispersions with phosphatidylcholine (PC) contents up to 600 mg/g or 780 mM were obtained by high-pressure homogenization. Dilution of these pastes with excess buffer led to `classical' liposome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a70a9c047afe675cfe992a6dd47bd29
https://doi.org/10.1016/s0378-5173(98)00146-x

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Morphology of semisolid aqueous phosphatidylcholine dispersions, a freeze fracture electron microscopy study

Autor: Kurt-Heinz Bauer, Dieter Bachmann, Martin Brandl, Markus Drechsler

Publikováno v: Chemistry and Physics of Lipids. 87:65-72

Semisolid aqueous dispersions of soy phosphatidylcholine (PC) with high PC mass fractions between 0.35 and 0.6 were prepared using a high-pressure homogeniser. Their morphologies were investigated by freeze fracture transmission electron microscopy (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1893563c590c5d41604e5764e6a90da5
https://doi.org/10.1016/s0009-3084(97)00028-5

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Three-dimensional liposome networks: freeze fracture electron microscopical evaluation of their structure and in vitro analysis of release of hydrophilic markers

Autor: Rolf Schubert, Markus Drechsler, Regina Reszka, Christine Tardi, Dieter Bachmann, Martin Brandl, Kurt-Heinz Bauer

Publikováno v: Advanced Drug Delivery Reviews. 24:161-164

This paper summarises first experiences with highly concentrated, semisolid phospholipid dispersions. Their preparation is based on ‘forced hydration’ of (phospho-)lipid(s) by high-pressure homogenisation in the presence of relatively low amounts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3887c63ed0a3bada5a12656ba8ceaa4e
https://doi.org/10.1016/s0169-409x(96)00455-3

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Development of a Parenterally Administrable Hydrosol Preparation of the 'Third Generation Platinum Complex' [(±)-1,2-Bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and Studies on the Stability and Antitumor Activity

Autor: Kurt-Heinz Bauer, Zhi Lu, Thilo Spruss, Sabine Schertl, Günther Bernhardt, Helmut Schönenberger, Rudolf Krauser, Marion Koch, Ronald Gust

Publikováno v: Archiv der Pharmazie. 328:645-653

The development of a galenical formulation for poorly water soluble dichloroplatinum(II) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+/-)-1,2-bis(4-fluorophenyl)et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0d123b4d5b5b573af8f5be4143abbd
https://doi.org/10.1002/ardp.19953280904

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Liposome Preparation by a New High Pressure Homogenizer Gaulin Micron Lab 40

Autor: Martin Brandl, Dieter Bachmann, Markus Drechsler, Kurt-Heinz Bauer

Publikováno v: Drug Development and Industrial Pharmacy. 16:2167-2191

High pressure expansion of lipid dispersions with a lab-scale homogenizer (Gaulin Micron LAB 4 0) was tested to produce forced lecithin hydration and subsequent liposome formation. A single-step li...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8a0cbb67f232f832930a1b23b0ff3d8
https://doi.org/10.3109/03639049009023648

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Hemoglobin-Liposomes as Blood Replacement Fluid

Autor: Martin Brandl, D. Becker, Kurt-Heinz Bauer

Publikováno v: Drug Development and Industrial Pharmacy. 15:655-669

Human hemoglobin is encapsulated in unilamellar liposomes by French press extrusion in order to form hemoglobin liposomes (HBL). The mean diameter of the HBL is 50 nm by TEM. Therefore the preparation can be passed through microbial retentive filters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::756df412e3b0f3035451a694657b50f8
https://doi.org/10.3109/03639048909058524

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[Untitled]

Autor: Andreas Leonhardt, Karl-Heinz Foiβner, Gerhard Wegner, Kurt Heinz Bauer

Publikováno v: Pharmaceutical Research. :44-46

The content of dissolved oxygen was determined by four independent methods in a series of non-aqueous or heterogenous systems. The Lex-O2-Content Analyzer represents a fast and simple apparatus that employs a coulometric oxygen assay with Hersch cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eebc04b395c3e85b8f336e35ebc67526
https://doi.org/10.1023/a:1016370123621

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