Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kurt Freter"'
Autor:
Thelma LeClerq, Hin Chor Wong, Kurt Freter, Ernest Cullen, Reinhold Becker, Genus J. Possanza
Publikováno v:
Journal of medicinal chemistry. 35(2)
A series of benzobisthiazoles were screened for antiinflammatory activity in the carrageenan paw edema and adjuvant arthritis tests. Compound 26, 2,6-bis(N,N-diethylamino)benzo[1,2-d:5,4-d']bisthiazole, was found to inhibit the swelling of the uninje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bf6cfd82de2e13845a4714c42399fe
https://pubmed.ncbi.nlm.nih.gov/1732553
https://pubmed.ncbi.nlm.nih.gov/1732553
Publikováno v:
Journal of Medicinal Chemistry. 20:205-209
The synthesis and properties of the title compounds 1 are described. Many of these compounds are potent inhibitors of the passive cutaneous anaphylaxis reaction of rats against egg albumin challenge. Structural variations include substitutions in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6308be4e47e5d9b9401b8f14129cd559
https://doi.org/10.1021/jm00212a004
https://doi.org/10.1021/jm00212a004
Autor:
Kurt Freter
Publikováno v:
Pharmaceutical Research. :397-400
Novel drugs presently introduced in the market are largely not discovered by rational design or by random screening but, rather, are products of evolution of existing leads (analogue research). It is suggested that this will change in the near future
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48b282d1251752a2ed9c6444fd54994e
https://doi.org/10.1023/a:1015924014805
https://doi.org/10.1023/a:1015924014805
Autor:
Kurt Freter
Publikováno v:
Justus Liebigs Annalen der Chemie. 1978:1357-1364
Die Octahydro[1]benzopyrano[3,4-b]indole 7 wurden durch Bortrifluorid-katalysierte Kondensation von 2-(3-Indolyl)cyclohexanol (5) mit einer Reihe von Ketonen hergestellt. Die Synthese der Zwischenstufe 5 durch Cycloalkenylierung von Indol und Redukti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0f2f241bbf327424b1ab7052719d9d8
https://doi.org/10.1002/jlac.197819780817
https://doi.org/10.1002/jlac.197819780817
Publikováno v:
Journal of Heterocyclic Chemistry. 24:387-391
Reactions de chloroacetylaminomethyl-4 indoles (prepares par amidomethylation des methoxy-5 methyl-2 et trimethyl-2,5,6 indoles) avec la N-acetyl piperidone-4 ou des derives du benzaldehyde: obtention de spiro [piperidine-4:3'-pyrrolo [4,3,2-de] isoq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e1a20b99ec524b8803fcca7afd1ad1
https://doi.org/10.1002/jhet.5570240218
https://doi.org/10.1002/jhet.5570240218
Publikováno v:
Journal of Heterocyclic Chemistry. 25:1701-1704
Phenanthridine reacts with N-(hydroxymethyl)phthalimide to give, in two steps, three monosubstituted aminomethylphenanthridines. The three isomers were separated by chromatography on silica gel. The position of substitution was determined using one-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec69f4d9709c1721d4773b4aba67222
https://doi.org/10.1002/jhet.5570250617
https://doi.org/10.1002/jhet.5570250617
Autor:
Kurt Freter
Publikováno v:
The Journal of Organic Chemistry. 40:2525-2529
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab7e7df1600ae3a5298ae1a0ac89f80
https://doi.org/10.1021/jo00905a023
https://doi.org/10.1021/jo00905a023
Publikováno v:
Experimental Biology and Medicine. 94:725-728
SummaryThe d and l forms of 5-hydroxy-tryptophan were prepared. Only the l form was found to be acted on by 5HTP decarboxylase, to increase brain serotonin levels in vivo, and to be pharmacologically active.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d1c32995d61b40e9e344822a49a74b
https://doi.org/10.3181/00379727-94-23066
https://doi.org/10.3181/00379727-94-23066
Publikováno v:
Justus Liebigs Annalen der Chemie. 684:159-187
1-Aryl-1.2.3.4-tetrahydro-β-carboline bilden in saurem Medium dimere Reaktionsprodukte. Analog und viel glatter reagieren 1-Aryl-1.2.3.4-tetrahydro-β-carboline mit Indolen zu gemischten Dimeren. Auf Grund der durchgefuhrten Strukturaufklarung hande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9d966e7dccd274d7824ebe0de0aca00
https://doi.org/10.1002/jlac.19656840118
https://doi.org/10.1002/jlac.19656840118
Autor:
Kurt Freter
Publikováno v:
Justus Liebigs Annalen der Chemie. 721:101-104
Durch Erhitzen von Phenylchloracetyltryptaminen 1 in einer Mischung aus Eisessig und verd. Phosphorsaure entstehen 1.2.3.4.5.6-Hexahydro-5-phenyl-4-oxo-azepino[4.5-b]indole (2), die zu den entsprechenden Aminen 5 reduziert werden konnen. Preparation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0048d16b3cd4cbcf337fd3325da9a3c
https://doi.org/10.1002/jlac.19697210114
https://doi.org/10.1002/jlac.19697210114